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Article: Seipin Knockout Mice Develop Heart Failure With Preserved Ejection Fraction

TitleSeipin Knockout Mice Develop Heart Failure With Preserved Ejection Fraction
Authors
Keywordsfibrosis
heart failure with preserved ejection fraction
neutrophil
seipin
titin
Issue Date2019
PublisherElsevier: Creative Commons Licenses. The Journal's web site is located at https://www.journals.elsevier.com/jacc-basic-to-translational-science
Citation
JACC: Basic to Translational Science, 2019, v. 4 n. 8, p. 924-937 How to Cite?
AbstractThe lean diabetic patients with heart failure with preserved ejection fraction (HFpEF) in Asia suffer from adverse clinical outcomes and poor life quality. The suitable animal models are urgently needed for mechanistic study and therapeutic innovations. Our study reports that lipodystrophic mice with seipin depletion are lean, diabetic, and recapitulate major manifestations of clinical HFpEF, thereby clarifying that lean diabetes per se may produce HFpEF characteristics. We further demonstrate that increased cardiac titin phosphorylation and reactive interstitial fibrosis associated with neutrophil extracellular traps lead to left ventricular stiffness and suggest that both pathways may be potential therapeutic targets in Asian HFpEF patients.
Persistent Identifierhttp://hdl.handle.net/10722/293389
ISSN
2023 Impact Factor: 8.4
2023 SCImago Journal Rankings: 2.690
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBai, B-
dc.contributor.authorYang, W-
dc.contributor.authorFu, Y-
dc.contributor.authorFoon, HL-
dc.contributor.authorTay, WT-
dc.contributor.authorYang, K-
dc.contributor.authorLuo, C-
dc.contributor.authorGunaratne, J-
dc.contributor.authorLee, P-
dc.contributor.authorZile, MR-
dc.contributor.authorXu, A-
dc.contributor.authorChin, CWL-
dc.contributor.authorLam, CSP-
dc.contributor.authorHan, WP-
dc.contributor.authorWang, Y-
dc.date.accessioned2020-11-23T08:16:02Z-
dc.date.available2020-11-23T08:16:02Z-
dc.date.issued2019-
dc.identifier.citationJACC: Basic to Translational Science, 2019, v. 4 n. 8, p. 924-937-
dc.identifier.issn2452-302X-
dc.identifier.urihttp://hdl.handle.net/10722/293389-
dc.description.abstractThe lean diabetic patients with heart failure with preserved ejection fraction (HFpEF) in Asia suffer from adverse clinical outcomes and poor life quality. The suitable animal models are urgently needed for mechanistic study and therapeutic innovations. Our study reports that lipodystrophic mice with seipin depletion are lean, diabetic, and recapitulate major manifestations of clinical HFpEF, thereby clarifying that lean diabetes per se may produce HFpEF characteristics. We further demonstrate that increased cardiac titin phosphorylation and reactive interstitial fibrosis associated with neutrophil extracellular traps lead to left ventricular stiffness and suggest that both pathways may be potential therapeutic targets in Asian HFpEF patients.-
dc.languageeng-
dc.publisherElsevier: Creative Commons Licenses. The Journal's web site is located at https://www.journals.elsevier.com/jacc-basic-to-translational-science-
dc.relation.ispartofJACC: Basic to Translational Science-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectfibrosis-
dc.subjectheart failure with preserved ejection fraction-
dc.subjectneutrophil-
dc.subjectseipin-
dc.subjecttitin-
dc.titleSeipin Knockout Mice Develop Heart Failure With Preserved Ejection Fraction-
dc.typeArticle-
dc.identifier.emailBai, B: baibohku@hku.hk-
dc.identifier.emailYang, K: yangkm@hku.hk-
dc.identifier.emailLuo, C: cuiting@hku.hk-
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.emailWang, Y: yuwanghk@hku.hk-
dc.identifier.authorityXu, A=rp00485-
dc.identifier.authorityWang, Y=rp00239-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.jacbts.2019.07.008-
dc.identifier.pmid31909301-
dc.identifier.pmcidPMC6939002-
dc.identifier.scopuseid_2-s2.0-85076697399-
dc.identifier.hkuros320045-
dc.identifier.volume4-
dc.identifier.issue8-
dc.identifier.spage924-
dc.identifier.epage937-
dc.identifier.isiWOS:000613157200007-
dc.publisher.placeUnited States-
dc.identifier.issnl2452-302X-

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