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Article: Escaping the Lion’s Den: redirecting autophagy for unconventional release and spread of viruses

TitleEscaping the Lion’s Den: redirecting autophagy for unconventional release and spread of viruses
Authors
Keywordscell‐to‐cell spread
nondegradative autophagy
RNA viruses
secretion
Issue Date2021
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1742-4658
Citation
The FEBS Journal, 2021, v. 288 n. 13, p. 3913-3927 How to Cite?
AbstractAutophagy is an evolutionarily conserved process, designed to maintain cellular homeostasis during a range of internal and external stimuli. Conventionally, autophagy is known for coordinated degradation and recycling of intracellular components and removal of cytosolic pathogens. More recently, several lines of evidence have indicated an unconventional, nondegradative role of autophagy for secretion of cargo that lacks a signal peptide. This process referred to as secretory autophagy has also been implicated in the infection cycle of several virus species. This review focuses on the current evidence available on the nondegradative features of autophagy, emphasizing its potential role and unresolved questions in the release and spread of (−) and (+) RNA viruses.
DescriptionHybrid open access
Persistent Identifierhttp://hdl.handle.net/10722/293481
ISSN
2023 Impact Factor: 5.5
2023 SCImago Journal Rankings: 2.003
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTeo, QW-
dc.contributor.authorvan Leur, SW-
dc.contributor.authorSanyal, S-
dc.date.accessioned2020-11-23T08:17:24Z-
dc.date.available2020-11-23T08:17:24Z-
dc.date.issued2021-
dc.identifier.citationThe FEBS Journal, 2021, v. 288 n. 13, p. 3913-3927-
dc.identifier.issn1742-464X-
dc.identifier.urihttp://hdl.handle.net/10722/293481-
dc.descriptionHybrid open access-
dc.description.abstractAutophagy is an evolutionarily conserved process, designed to maintain cellular homeostasis during a range of internal and external stimuli. Conventionally, autophagy is known for coordinated degradation and recycling of intracellular components and removal of cytosolic pathogens. More recently, several lines of evidence have indicated an unconventional, nondegradative role of autophagy for secretion of cargo that lacks a signal peptide. This process referred to as secretory autophagy has also been implicated in the infection cycle of several virus species. This review focuses on the current evidence available on the nondegradative features of autophagy, emphasizing its potential role and unresolved questions in the release and spread of (−) and (+) RNA viruses.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1742-4658-
dc.relation.ispartofThe FEBS Journal-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectcell‐to‐cell spread-
dc.subjectnondegradative autophagy-
dc.subjectRNA viruses-
dc.subjectsecretion-
dc.titleEscaping the Lion’s Den: redirecting autophagy for unconventional release and spread of viruses-
dc.typeArticle-
dc.identifier.emailSanyal, S: sanyal@hku.hk-
dc.identifier.authoritySanyal, S=rp01794-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1111/febs.15590-
dc.identifier.scopuseid_2-s2.0-85093825032-
dc.identifier.hkuros320173-
dc.identifier.volume288-
dc.identifier.issue13-
dc.identifier.spage3913-
dc.identifier.epage3927-
dc.identifier.isiWOS:000583606900001-
dc.publisher.placeUnited Kingdom-

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