File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.phrs.2020.104877
- Scopus: eid_2-s2.0-85084520084
- PMID: 32407958
- WOS: WOS:000542124500058
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Therapeutic targets of oxidative/nitrosative stress and neuro inflammation in ischemic stroke: Applications for natural product efficacy with omics and systemic biology.
Title | Therapeutic targets of oxidative/nitrosative stress and neuro inflammation in ischemic stroke: Applications for natural product efficacy with omics and systemic biology. |
---|---|
Authors | |
Keywords | Ischemic stroke Innate immune receptors Neuroinflammation Oxidative/nitrosative stress Chinese medicine |
Issue Date | 2020 |
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/issn/10436618 |
Citation | Pharmacological Research, 2020, v. 158, p. article no. 104877 How to Cite? |
Abstract | Oxidative/nitrosative stress and neuroinflammation are critical pathological processes in cerebral ischemia-reperfusion injury, and their intimate interactions mediate neuronal damage, blood-brain barrier (BBB) damage and hemorrhagic transformation (HT) during ischemic stroke. We review current progress towards understanding the interactions of oxidative/nitrosative stress and inflammatory responses in ischemic brain injury. The interactions between reactive oxygen species (ROS)/reactive nitrogen species (RNS) and innate immune receptors such as TLR2/4, NOD-like receptor, RAGE, and scavenger receptors are crucial pathological mechanisms that amplify brain damage during cerebral ischemic injury. Furthermore, we review the current progress of omics and systematic biology approaches for studying complex network regulations related to oxidative/nitrosative stress and inflammation in the pathology of ischemic stroke. Targeting oxidative/nitrosative stress and neuroinflammation could be a promising therapeutic strategy for ischemic stroke treatment. We then review recent advances in discovering compounds from medicinal herbs with the bioactivities of simultaneously regulating oxidative/nitrosative stress and pro-inflammatory molecules for minimizing ischemic brain injury. These compounds include sesamin, baicalin, salvianolic acid A, 6-paradol, silymarin, apocynin, 3H-1,2-Dithiole-3-thione, (−)-epicatechin, rutin, Dl-3-N-butylphthalide, and naringin. We finally summarize recent developments of the omics and systematic biology approaches for exploring the molecular mechanisms and active compounds of Traditional Chinese Medicine (TCM) formulae with the properties of antioxidant and anti-inflammation for neuroprotection. The comprehensive omics and systematic biology approaches provide powerful tools for exploring therapeutic principles of TCM formulae and developing precision medicine for stroke treatment. |
Persistent Identifier | http://hdl.handle.net/10722/293645 |
ISSN | 2023 Impact Factor: 9.1 2023 SCImago Journal Rankings: 2.160 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chen, H | - |
dc.contributor.author | HE, Y | - |
dc.contributor.author | CHEN, S | - |
dc.contributor.author | Qi, S | - |
dc.contributor.author | Shen, J | - |
dc.date.accessioned | 2020-11-23T08:19:46Z | - |
dc.date.available | 2020-11-23T08:19:46Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Pharmacological Research, 2020, v. 158, p. article no. 104877 | - |
dc.identifier.issn | 1043-6618 | - |
dc.identifier.uri | http://hdl.handle.net/10722/293645 | - |
dc.description.abstract | Oxidative/nitrosative stress and neuroinflammation are critical pathological processes in cerebral ischemia-reperfusion injury, and their intimate interactions mediate neuronal damage, blood-brain barrier (BBB) damage and hemorrhagic transformation (HT) during ischemic stroke. We review current progress towards understanding the interactions of oxidative/nitrosative stress and inflammatory responses in ischemic brain injury. The interactions between reactive oxygen species (ROS)/reactive nitrogen species (RNS) and innate immune receptors such as TLR2/4, NOD-like receptor, RAGE, and scavenger receptors are crucial pathological mechanisms that amplify brain damage during cerebral ischemic injury. Furthermore, we review the current progress of omics and systematic biology approaches for studying complex network regulations related to oxidative/nitrosative stress and inflammation in the pathology of ischemic stroke. Targeting oxidative/nitrosative stress and neuroinflammation could be a promising therapeutic strategy for ischemic stroke treatment. We then review recent advances in discovering compounds from medicinal herbs with the bioactivities of simultaneously regulating oxidative/nitrosative stress and pro-inflammatory molecules for minimizing ischemic brain injury. These compounds include sesamin, baicalin, salvianolic acid A, 6-paradol, silymarin, apocynin, 3H-1,2-Dithiole-3-thione, (−)-epicatechin, rutin, Dl-3-N-butylphthalide, and naringin. We finally summarize recent developments of the omics and systematic biology approaches for exploring the molecular mechanisms and active compounds of Traditional Chinese Medicine (TCM) formulae with the properties of antioxidant and anti-inflammation for neuroprotection. The comprehensive omics and systematic biology approaches provide powerful tools for exploring therapeutic principles of TCM formulae and developing precision medicine for stroke treatment. | - |
dc.language | eng | - |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/issn/10436618 | - |
dc.relation.ispartof | Pharmacological Research | - |
dc.subject | Ischemic stroke | - |
dc.subject | Innate immune receptors | - |
dc.subject | Neuroinflammation | - |
dc.subject | Oxidative/nitrosative stress | - |
dc.subject | Chinese medicine | - |
dc.title | Therapeutic targets of oxidative/nitrosative stress and neuro inflammation in ischemic stroke: Applications for natural product efficacy with omics and systemic biology. | - |
dc.type | Article | - |
dc.identifier.email | Shen, J: shenjg@hku.hk | - |
dc.identifier.authority | Shen, J=rp00487 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.phrs.2020.104877 | - |
dc.identifier.pmid | 32407958 | - |
dc.identifier.scopus | eid_2-s2.0-85084520084 | - |
dc.identifier.hkuros | 319912 | - |
dc.identifier.volume | 158 | - |
dc.identifier.spage | article no. 104877 | - |
dc.identifier.epage | article no. 104877 | - |
dc.identifier.isi | WOS:000542124500058 | - |
dc.publisher.place | United Kingdom | - |