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Article: Cost-effectiveness analysis of ceritinib vs. crizotinib in previously untreated anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) in Hong Kong

TitleCost-effectiveness analysis of ceritinib vs. crizotinib in previously untreated anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) in Hong Kong
Authors
KeywordsAdvanced non-small cell lung cancer
Anaplastic lymphoma kinase-positive
Ceritinib; cost-effectiveness
Hong Kong
Issue Date2020
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.resource-allocation.com/home/
Citation
Cost Effectiveness and Resource Allocation, 2020, v. 18 n. 1, p. article no. 50 How to Cite?
AbstractIntroduction: Lower-dose ceritinib (450 mg) once-daily with food was approved in 2018 in Hong Kong (HK) for first-line treatment of patients with anaplastic lymphoma kinase-positive (ALK +) advanced non-small cell lung cancer (NSCLC). This study examined the cost-effectiveness of ceritinib vs. crizotinib in the first-line treatment of ALK + NSCLC from a HK healthcare service provider's or government's perspective. Methods: Costs and effectiveness of first-line ceritinib vs. crizotinib over a 20-year time horizon was evaluated using a partitioned survival model with three health states (stable disease, progressed disease, and death). The efficacy data for ceritinib were obtained from a phase 3 trial comparing ceritinib with chemotherapy for advanced non-small cell lung cancer (ASCEND-4) and extrapolated using parametric survival models. Long-term survival associated with crizotinib were estimated using hazard ratio of crizotinib vs. ceritinib obtained from matching-adjusted indirect comparison based on ASCEND-4 and PROFILE 1014 trials. Drug acquisition, administration, adverse events costs, and medical costs associated with each health state were obtained from public sources and converted to 2018 US Dollars. Incremental costs per quality-adjusted-life-year (QALY) and life-year (LY) gained were estimated for ceritinib vs. crizotinib. Results: The base case results showed that ceritinib was associated with 3.22 QALYs, 4.51 LYs, and total costs of $157,581 over 20 years. Patients receiving crizotinib had 2.68 QALYs, 3.85 LYs, and $150,424 total costs over the same time horizon. The incremental cost per QALY gained for ceritinib vs crizotinib was $13,343. Results were robust to deterministic sensitivity analyses in most scenarios. Conclusion: Ceritinib offers a cost-effective option compared to crizotinib for previously untreated ALK + advanced NCSLC in HK.
Persistent Identifierhttp://hdl.handle.net/10722/293689
ISSN
2020 Impact Factor: 2.532
2015 SCImago Journal Rankings: 0.767
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLoong, HH-
dc.contributor.authorWong, CKH-
dc.contributor.authorLeung, LKS-
dc.contributor.authorChan, CPK-
dc.contributor.authorChang, A-
dc.contributor.authorZhou, ZY-
dc.contributor.authorXie, J-
dc.contributor.authorGibbs, M-
dc.date.accessioned2020-11-23T08:20:23Z-
dc.date.available2020-11-23T08:20:23Z-
dc.date.issued2020-
dc.identifier.citationCost Effectiveness and Resource Allocation, 2020, v. 18 n. 1, p. article no. 50-
dc.identifier.issn1478-7547-
dc.identifier.urihttp://hdl.handle.net/10722/293689-
dc.description.abstractIntroduction: Lower-dose ceritinib (450 mg) once-daily with food was approved in 2018 in Hong Kong (HK) for first-line treatment of patients with anaplastic lymphoma kinase-positive (ALK +) advanced non-small cell lung cancer (NSCLC). This study examined the cost-effectiveness of ceritinib vs. crizotinib in the first-line treatment of ALK + NSCLC from a HK healthcare service provider's or government's perspective. Methods: Costs and effectiveness of first-line ceritinib vs. crizotinib over a 20-year time horizon was evaluated using a partitioned survival model with three health states (stable disease, progressed disease, and death). The efficacy data for ceritinib were obtained from a phase 3 trial comparing ceritinib with chemotherapy for advanced non-small cell lung cancer (ASCEND-4) and extrapolated using parametric survival models. Long-term survival associated with crizotinib were estimated using hazard ratio of crizotinib vs. ceritinib obtained from matching-adjusted indirect comparison based on ASCEND-4 and PROFILE 1014 trials. Drug acquisition, administration, adverse events costs, and medical costs associated with each health state were obtained from public sources and converted to 2018 US Dollars. Incremental costs per quality-adjusted-life-year (QALY) and life-year (LY) gained were estimated for ceritinib vs. crizotinib. Results: The base case results showed that ceritinib was associated with 3.22 QALYs, 4.51 LYs, and total costs of $157,581 over 20 years. Patients receiving crizotinib had 2.68 QALYs, 3.85 LYs, and $150,424 total costs over the same time horizon. The incremental cost per QALY gained for ceritinib vs crizotinib was $13,343. Results were robust to deterministic sensitivity analyses in most scenarios. Conclusion: Ceritinib offers a cost-effective option compared to crizotinib for previously untreated ALK + advanced NCSLC in HK.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.resource-allocation.com/home/-
dc.relation.ispartofCost Effectiveness and Resource Allocation-
dc.rightsCost Effectiveness and Resource Allocation. Copyright © BioMed Central Ltd.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAdvanced non-small cell lung cancer-
dc.subjectAnaplastic lymphoma kinase-positive-
dc.subjectCeritinib; cost-effectiveness-
dc.subjectHong Kong-
dc.titleCost-effectiveness analysis of ceritinib vs. crizotinib in previously untreated anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) in Hong Kong-
dc.typeArticle-
dc.identifier.emailWong, CKH: carlosho@hku.hk-
dc.identifier.authorityWong, CKH=rp01931-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s12962-020-00244-6-
dc.identifier.pmid33292314-
dc.identifier.pmcidPMC7648263-
dc.identifier.scopuseid_2-s2.0-85097568090-
dc.identifier.hkuros318984-
dc.identifier.volume18-
dc.identifier.issue1-
dc.identifier.spagearticle no. 50-
dc.identifier.epagearticle no. 50-
dc.identifier.isiWOS:000587300900001-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1478-7547-

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