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- Publisher Website: 10.1007/s00018-020-03460-8
- Scopus: eid_2-s2.0-85078937032
- PMID: 32008088
- WOS: WOS:000510366800001
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Article: Epigenetic regulation of centromere function
Title | Epigenetic regulation of centromere function |
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Authors | |
Keywords | Centromere Post-translational modifications Histone modifications Non-coding transcription Centromeric transcript |
Issue Date | 2020 |
Publisher | Birkhaeuser Verlag AG. The Journal's web site is located at http://link.springer.de/link/service/journals/00018/index.htm |
Citation | Cellular and Molecular Life Sciences, 2020, v. 77 n. 15, p. 2899-2917 How to Cite? |
Abstract | The centromere is a specialized region on the chromosome that directs equal chromosome segregation. Centromeres are usually not defined by DNA sequences alone. How centromere formation and function are determined by epigenetics is still not fully understood. Active centromeres are often marked by the presence of centromeric-specific histone H3 variant, centromere protein A (CENP-A). How CENP-A is assembled into the centromeric chromatin during the cell cycle and propagated to the next cell cycle or the next generation to maintain the centromere function has been intensively investigated. In this review, we summarize current understanding of how post-translational modifications of CENP-A and other centromere proteins, centromeric and pericentric histone modifications, non-coding transcription and transcripts contribute to centromere function, and discuss their intricate relationships and potential feedback mechanisms. |
Persistent Identifier | http://hdl.handle.net/10722/293943 |
ISSN | 2023 Impact Factor: 6.2 2023 SCImago Journal Rankings: 2.274 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wong, CYY | - |
dc.contributor.author | Lee, BCH | - |
dc.contributor.author | Yuen, KWY | - |
dc.date.accessioned | 2020-11-23T08:24:05Z | - |
dc.date.available | 2020-11-23T08:24:05Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Cellular and Molecular Life Sciences, 2020, v. 77 n. 15, p. 2899-2917 | - |
dc.identifier.issn | 1420-682X | - |
dc.identifier.uri | http://hdl.handle.net/10722/293943 | - |
dc.description.abstract | The centromere is a specialized region on the chromosome that directs equal chromosome segregation. Centromeres are usually not defined by DNA sequences alone. How centromere formation and function are determined by epigenetics is still not fully understood. Active centromeres are often marked by the presence of centromeric-specific histone H3 variant, centromere protein A (CENP-A). How CENP-A is assembled into the centromeric chromatin during the cell cycle and propagated to the next cell cycle or the next generation to maintain the centromere function has been intensively investigated. In this review, we summarize current understanding of how post-translational modifications of CENP-A and other centromere proteins, centromeric and pericentric histone modifications, non-coding transcription and transcripts contribute to centromere function, and discuss their intricate relationships and potential feedback mechanisms. | - |
dc.language | eng | - |
dc.publisher | Birkhaeuser Verlag AG. The Journal's web site is located at http://link.springer.de/link/service/journals/00018/index.htm | - |
dc.relation.ispartof | Cellular and Molecular Life Sciences | - |
dc.rights | This is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI] | - |
dc.subject | Centromere | - |
dc.subject | Post-translational modifications | - |
dc.subject | Histone modifications | - |
dc.subject | Non-coding transcription | - |
dc.subject | Centromeric transcript | - |
dc.title | Epigenetic regulation of centromere function | - |
dc.type | Article | - |
dc.identifier.email | Yuen, KWY: kwyyuen@hku.hk | - |
dc.identifier.authority | Yuen, KWY=rp01512 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s00018-020-03460-8 | - |
dc.identifier.pmid | 32008088 | - |
dc.identifier.scopus | eid_2-s2.0-85078937032 | - |
dc.identifier.hkuros | 320167 | - |
dc.identifier.volume | 77 | - |
dc.identifier.issue | 15 | - |
dc.identifier.spage | 2899 | - |
dc.identifier.epage | 2917 | - |
dc.identifier.isi | WOS:000510366800001 | - |
dc.publisher.place | Switzerland | - |