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Article: Engineering a Bi-Conical Microchip as Vascular Stenosis Model

TitleEngineering a Bi-Conical Microchip as Vascular Stenosis Model
Authors
Keywordsblood-vessel-like
microchip
bi-conical
vascular stenosis
wall shear rate
Issue Date2019
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/micromachines
Citation
Micromachines, 2019, v. 10 n. 11, p. article no. 790 How to Cite?
AbstractVascular stenosis is always associated with hemodynamic changes, especially shear stress alterations. Herein, bi-conical shaped microvessels were developed through flexibly and precisely controlled templated methods for hydrogel blood-vessel-like microchip. The blood-vessel-like microvessels demonstrated tunable dimensions, perfusable ability, and good cytocompatibility. The microchips showed blood-vessel-like lumens through fine embeddedness of human umbilical vein endothelial cells (HUVECs) on the interior surface of hydrogel microchannels, which closely reproduced the morphology and functions of human blood vessels. In the gradual narrowing region of bi-conical shape, fluid flow generated wall shear stress, which caused cell morphology variations. Wall shear rates at the gradual narrowing region were simulated by FLUENT software. The results showed that our microchannels qualified for performance as a vascular stenosis-like model in evaluating blood hydrodynamics. In general, our blood-vessel-on-a-chip could offer potential applications in the prevention, diagnosis, and therapy of arterial thrombosis.
Persistent Identifierhttp://hdl.handle.net/10722/294090
ISSN
2018 Impact Factor: 2.426
2015 SCImago Journal Rankings: 0.502
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Y-
dc.contributor.authorWang, J-
dc.contributor.authorWan, W-
dc.contributor.authorChen, C-
dc.contributor.authorWang, X-
dc.contributor.authorZhao, P-
dc.contributor.authorHou, Y-
dc.contributor.authorTian, H-
dc.contributor.authorWang, J-
dc.contributor.authorNandakumar, K-
dc.contributor.authorWang, L-
dc.date.accessioned2020-11-23T08:26:11Z-
dc.date.available2020-11-23T08:26:11Z-
dc.date.issued2019-
dc.identifier.citationMicromachines, 2019, v. 10 n. 11, p. article no. 790-
dc.identifier.issn2072-666X-
dc.identifier.urihttp://hdl.handle.net/10722/294090-
dc.description.abstractVascular stenosis is always associated with hemodynamic changes, especially shear stress alterations. Herein, bi-conical shaped microvessels were developed through flexibly and precisely controlled templated methods for hydrogel blood-vessel-like microchip. The blood-vessel-like microvessels demonstrated tunable dimensions, perfusable ability, and good cytocompatibility. The microchips showed blood-vessel-like lumens through fine embeddedness of human umbilical vein endothelial cells (HUVECs) on the interior surface of hydrogel microchannels, which closely reproduced the morphology and functions of human blood vessels. In the gradual narrowing region of bi-conical shape, fluid flow generated wall shear stress, which caused cell morphology variations. Wall shear rates at the gradual narrowing region were simulated by FLUENT software. The results showed that our microchannels qualified for performance as a vascular stenosis-like model in evaluating blood hydrodynamics. In general, our blood-vessel-on-a-chip could offer potential applications in the prevention, diagnosis, and therapy of arterial thrombosis.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/micromachines-
dc.relation.ispartofMicromachines-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectblood-vessel-like-
dc.subjectmicrochip-
dc.subjectbi-conical-
dc.subjectvascular stenosis-
dc.subjectwall shear rate-
dc.titleEngineering a Bi-Conical Microchip as Vascular Stenosis Model-
dc.typeArticle-
dc.identifier.emailWang, L: lqwang@hku.hk-
dc.identifier.authorityWang, L=rp00184-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/mi10110790-
dc.identifier.pmid31752172-
dc.identifier.pmcidPMC6915513-
dc.identifier.hkuros319549-
dc.identifier.volume10-
dc.identifier.issue11-
dc.identifier.spagearticle no. 790-
dc.identifier.epagearticle no. 790-
dc.identifier.isiWOS:000502255300076-
dc.publisher.placeSwitzerland-

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