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Article: Decidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7

TitleDecidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7
Authors
KeywordsGlycodelin
Progestagen-associated endometrial protein
PAEP
Macrophage
Trophoblast
Issue Date2020
PublisherThe Company of Biologists Ltd.
Citation
Journal of Cell Science, 2020, v. 133, p. article no. jcs244400 How to Cite?
AbstractDecidual macrophages constitute 20–30% of the total leukocytes in the uterus of pregnant women, regulating the maternal immune tolerance and placenta development. Abnormal number or activities of decidual macrophages (dMs) are associated with fetal loss and pregnancy complications, such as preeclampsia. Monocytes differentiate into dMs in a decidua-specific microenvironment. Despite their important roles in pregnancy, the exact factors that regulate the differentiation into dMs remain unclear. Glycodelin-A (PAEP, hereafter referred to as GdA) is a glycoprotein that is abundantly present in the decidua, and plays an important role in fetomaternal defense and placental development. It modulates the differentiation and activity of several immune cell types residing in the decidua. In this study, we demonstrated that GdA induces the differentiation of human monocytes into dM-like phenotypes in terms of transcriptome, cell surface marker expression, secretome, and regulation of trophoblast and endothelial cell functions. We found that Sialic acid-binding Ig-like lectin 7 (Siglec-7) mediates the binding and biological actions of GdA in a sialic acid-dependent manner. We, therefore, suggest that GdA, induces the polarization of monocytes into dMs to regulate fetomaternal tolerance and placental development.
Persistent Identifierhttp://hdl.handle.net/10722/294194
ISSN
2023 Impact Factor: 3.3
2023 SCImago Journal Rankings: 1.587
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorVIJAYAN, M-
dc.contributor.authorLee, CL-
dc.contributor.authorWong, VHH-
dc.contributor.authorWANG, X-
dc.contributor.authorBAI, K-
dc.contributor.authorWu, J-
dc.contributor.authorKoistinen, H-
dc.contributor.authorSeppälä, M-
dc.contributor.authorLee, KF-
dc.contributor.authorYeung, WSB-
dc.contributor.authorNg, EHY-
dc.contributor.authorChiu, PCN-
dc.date.accessioned2020-11-23T08:27:42Z-
dc.date.available2020-11-23T08:27:42Z-
dc.date.issued2020-
dc.identifier.citationJournal of Cell Science, 2020, v. 133, p. article no. jcs244400-
dc.identifier.issn0021-9533-
dc.identifier.urihttp://hdl.handle.net/10722/294194-
dc.description.abstractDecidual macrophages constitute 20–30% of the total leukocytes in the uterus of pregnant women, regulating the maternal immune tolerance and placenta development. Abnormal number or activities of decidual macrophages (dMs) are associated with fetal loss and pregnancy complications, such as preeclampsia. Monocytes differentiate into dMs in a decidua-specific microenvironment. Despite their important roles in pregnancy, the exact factors that regulate the differentiation into dMs remain unclear. Glycodelin-A (PAEP, hereafter referred to as GdA) is a glycoprotein that is abundantly present in the decidua, and plays an important role in fetomaternal defense and placental development. It modulates the differentiation and activity of several immune cell types residing in the decidua. In this study, we demonstrated that GdA induces the differentiation of human monocytes into dM-like phenotypes in terms of transcriptome, cell surface marker expression, secretome, and regulation of trophoblast and endothelial cell functions. We found that Sialic acid-binding Ig-like lectin 7 (Siglec-7) mediates the binding and biological actions of GdA in a sialic acid-dependent manner. We, therefore, suggest that GdA, induces the polarization of monocytes into dMs to regulate fetomaternal tolerance and placental development.-
dc.languageeng-
dc.publisherThe Company of Biologists Ltd.-
dc.relation.ispartofJournal of Cell Science-
dc.subjectGlycodelin-
dc.subjectProgestagen-associated endometrial protein-
dc.subjectPAEP-
dc.subjectMacrophage-
dc.subjectTrophoblast-
dc.titleDecidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7-
dc.typeArticle-
dc.identifier.emailLee, CL: kcllee@hku.hk-
dc.identifier.emailLee, KF: ckflee@hku.hk-
dc.identifier.emailYeung, WSB: wsbyeung@hku.hk-
dc.identifier.emailNg, EHY: nghye@hku.hk-
dc.identifier.emailChiu, PCN: pchiucn@hku.hk-
dc.identifier.authorityLee, CL=rp02515-
dc.identifier.authorityLee, KF=rp00458-
dc.identifier.authorityYeung, WSB=rp00331-
dc.identifier.authorityNg, EHY=rp00426-
dc.identifier.authorityChiu, PCN=rp00424-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1242/jcs.244400-
dc.identifier.pmid32513821-
dc.identifier.scopuseid_2-s2.0-85088609067-
dc.identifier.hkuros319478-
dc.identifier.volume133-
dc.identifier.spagearticle no. jcs244400-
dc.identifier.epagearticle no. jcs244400-
dc.identifier.isiWOS:000561043800018-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0021-9533-

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