File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Systematic review of pregnancy outcomes after fertility-preserving treatment of uterine fibroids

TitleSystematic review of pregnancy outcomes after fertility-preserving treatment of uterine fibroids
Authors
KeywordsFibroid ablation
Myomectomy
Pregnancy outcomes
Ulipristal acetate
Uterine artery embolization
Issue Date2020
PublisherElsevier Ltd. The Journal's web site is located at http://www.rbmojournal.com
Citation
Reproductive BioMedicine Online, 2020, v. 40 n. 3, p. 429-444 How to Cite?
AbstractThe aim of this study was to compare pregnancy outcomes after medical (ulipristal acetate [UPA]), surgical (myomectomy) and radiological (uterine artery embolization [UAE] or thermal ablation) therapy for fibroids in women. A systematic review was conducted and ScienceDirect, PubMed, Web of Science and Cochrane Library databases were thoroughly searched from 2000 to 2018. Only primary research was included with independent extraction of articles by two reviewers, using a standardized form. Data were available on 12 pregnancies after treatment with UPA, 1575 after myomectomy, 424 after UAE and 420 after fibroid ablation. Results after UPA therapy were not included in the statistical analysis owing to the limited number of cases; most were ongoing pregnancies. High rates of successful pregnancy were seen after myomectomy (75.6%) and fibroid ablation (70.5%), whereas pregnancies after UAE had the lowest live birth rates (60.6%) and highest miscarriage rates (27.4%) (both P < 0.001 versus other treatments). In conclusion, myomectomy is associated with better pregnancy outcomes than other fertility-preserving treatments for fibroids. At present, UPA is the only medical treatment for fibroids; however, the evidence on pregnancy outcome is limited. In the absence of randomized controlled trials, these data may be of benefit in advising patients about future pregnancy.
Persistent Identifierhttp://hdl.handle.net/10722/294301
ISSN
2020 Impact Factor: 3.828
2015 SCImago Journal Rankings: 1.459
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKHAW, SC-
dc.contributor.authorANDERSON, RA-
dc.contributor.authorLui, MW-
dc.date.accessioned2020-11-23T08:29:25Z-
dc.date.available2020-11-23T08:29:25Z-
dc.date.issued2020-
dc.identifier.citationReproductive BioMedicine Online, 2020, v. 40 n. 3, p. 429-444-
dc.identifier.issn1472-6483-
dc.identifier.urihttp://hdl.handle.net/10722/294301-
dc.description.abstractThe aim of this study was to compare pregnancy outcomes after medical (ulipristal acetate [UPA]), surgical (myomectomy) and radiological (uterine artery embolization [UAE] or thermal ablation) therapy for fibroids in women. A systematic review was conducted and ScienceDirect, PubMed, Web of Science and Cochrane Library databases were thoroughly searched from 2000 to 2018. Only primary research was included with independent extraction of articles by two reviewers, using a standardized form. Data were available on 12 pregnancies after treatment with UPA, 1575 after myomectomy, 424 after UAE and 420 after fibroid ablation. Results after UPA therapy were not included in the statistical analysis owing to the limited number of cases; most were ongoing pregnancies. High rates of successful pregnancy were seen after myomectomy (75.6%) and fibroid ablation (70.5%), whereas pregnancies after UAE had the lowest live birth rates (60.6%) and highest miscarriage rates (27.4%) (both P < 0.001 versus other treatments). In conclusion, myomectomy is associated with better pregnancy outcomes than other fertility-preserving treatments for fibroids. At present, UPA is the only medical treatment for fibroids; however, the evidence on pregnancy outcome is limited. In the absence of randomized controlled trials, these data may be of benefit in advising patients about future pregnancy.-
dc.languageeng-
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.rbmojournal.com-
dc.relation.ispartofReproductive BioMedicine Online-
dc.subjectFibroid ablation-
dc.subjectMyomectomy-
dc.subjectPregnancy outcomes-
dc.subjectUlipristal acetate-
dc.subjectUterine artery embolization-
dc.titleSystematic review of pregnancy outcomes after fertility-preserving treatment of uterine fibroids-
dc.typeArticle-
dc.identifier.emailLui, MW: ellenlui@hku.hk-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.rbmo.2020.01.003-
dc.identifier.pmid32081542-
dc.identifier.hkuros319304-
dc.identifier.volume40-
dc.identifier.issue3-
dc.identifier.spage429-
dc.identifier.epage444-
dc.identifier.isiWOS:000519987700012-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats