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- Publisher Website: 10.1111/and.13565
- Scopus: eid_2-s2.0-85081954362
- PMID: 32187723
- WOS: WOS:000520284900001
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Article: Platelet‐activating factor induces acrosome reaction via the activation of extracellular signal‐regulated kinase in human spermatozoa
| Title | Platelet‐activating factor induces acrosome reaction via the activation of extracellular signal‐regulated kinase in human spermatozoa |
|---|---|
| Authors | |
| Keywords | acrosome reaction ERK human spermatozoa motility platelet‐activating factor |
| Issue Date | 2020 |
| Publisher | Wiley: 12 months. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AND |
| Citation | Andrologia, 2020, v. 52 n. 5, p. article no. e13565 How to Cite? |
| Abstract | Platelet‐activating factor (PAF) affects capacitation, acrosome reaction and fertilisation potential of spermatozoa. This study investigated the underlying mechanism(s) through which PAF regulated sperm function. Our data demonstrated that PAF dose‐dependently induced, whilst lyso‐PAF (PAF precursor) showed no effect on acrosome reaction of capacitated human spermatozoa. Treatment with PAF for 90 min enhanced tyrosine phosphorylation and expression of extracellular signal‐regulated protein kinases (ERK) 1 and 2 in human spermatozoa. Moreover, pre‐treatment with the ERK inhibitor U0126 significantly and dose‐dependently suppressed PAF‐induced acrosome reaction. Therefore, PAF may be actively involved in the modulation of sperm acrosome reaction by interacting with ERK. The role of PAF in fertilisation warrants further investigation. |
| Persistent Identifier | http://hdl.handle.net/10722/294303 |
| ISSN | 2021 Impact Factor: 2.532 2020 SCImago Journal Rankings: 0.633 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Wu, H | - |
| dc.contributor.author | Gao, J | - |
| dc.contributor.author | WANG, X | - |
| dc.contributor.author | LEUNG, TY | - |
| dc.contributor.author | Duan, YG | - |
| dc.contributor.author | Chiu, PCN | - |
| dc.date.accessioned | 2020-11-23T08:29:27Z | - |
| dc.date.available | 2020-11-23T08:29:27Z | - |
| dc.date.issued | 2020 | - |
| dc.identifier.citation | Andrologia, 2020, v. 52 n. 5, p. article no. e13565 | - |
| dc.identifier.issn | 0303-4569 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/294303 | - |
| dc.description.abstract | Platelet‐activating factor (PAF) affects capacitation, acrosome reaction and fertilisation potential of spermatozoa. This study investigated the underlying mechanism(s) through which PAF regulated sperm function. Our data demonstrated that PAF dose‐dependently induced, whilst lyso‐PAF (PAF precursor) showed no effect on acrosome reaction of capacitated human spermatozoa. Treatment with PAF for 90 min enhanced tyrosine phosphorylation and expression of extracellular signal‐regulated protein kinases (ERK) 1 and 2 in human spermatozoa. Moreover, pre‐treatment with the ERK inhibitor U0126 significantly and dose‐dependently suppressed PAF‐induced acrosome reaction. Therefore, PAF may be actively involved in the modulation of sperm acrosome reaction by interacting with ERK. The role of PAF in fertilisation warrants further investigation. | - |
| dc.language | eng | - |
| dc.publisher | Wiley: 12 months. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AND | - |
| dc.relation.ispartof | Andrologia | - |
| dc.rights | This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
| dc.subject | acrosome reaction | - |
| dc.subject | ERK | - |
| dc.subject | human spermatozoa | - |
| dc.subject | motility | - |
| dc.subject | platelet‐activating factor | - |
| dc.title | Platelet‐activating factor induces acrosome reaction via the activation of extracellular signal‐regulated kinase in human spermatozoa | - |
| dc.type | Article | - |
| dc.identifier.email | Chiu, PCN: pchiucn@hku.hk | - |
| dc.identifier.authority | Chiu, PCN=rp00424 | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1111/and.13565 | - |
| dc.identifier.pmid | 32187723 | - |
| dc.identifier.scopus | eid_2-s2.0-85081954362 | - |
| dc.identifier.hkuros | 319345 | - |
| dc.identifier.volume | 52 | - |
| dc.identifier.issue | 5 | - |
| dc.identifier.spage | article no. e13565 | - |
| dc.identifier.epage | article no. e13565 | - |
| dc.identifier.isi | WOS:000520284900001 | - |
| dc.publisher.place | Germany | - |
| dc.identifier.issnl | 0303-4569 | - |