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Article: Effect of HLA class I or class II incompatibility in pediatric marrow transplantation from unrelated and related donors

TitleEffect of HLA class I or class II incompatibility in pediatric marrow transplantation from unrelated and related donors
Authors
KeywordsBone marrow transplantation
Pediatric
HLA
Issue Date2001
Citation
Human Immunology, 2001, v. 62, n. 4, p. 399-407 How to Cite?
AbstractThe degree of histoincompatibility that can be tolerated, and the relative importance of matching at individual HLA class I and class II locus in bone marrow transplantation (BMT) has not been established. We hypothesized that matching for HLA-DR may not be more important than matching for HLA-A or HLA-B in selection of a donor for successful BMT. We retrospectively analyzed the outcomes of 248 consecutive pediatric patients who received allogeneic BMT from related donors (RD, n = 119) or unrelated donors (URD, n = 129). HLA-A and HLA-B were serologically matched, and HLA-DRB1 were identical by DNA typing in 69% of donor-recipient pairs. Most patients (89%) had hematologic malignancies; the rest had aplastic anemia or a congenital disorder. One HLA-A antigen mismatch was associated with a decrease in survival (p = 0.003) and a delay in granulocyte engraftment (p = 0.02) in recipients of RD marrow; as well as a decrease in survival (p = 0.02) and the development of severe acute graft-versus-host disease (GVHD) (p = 0.03) in recipients of URD marrow. One HLA-B antigen mismatch was associated with a decrease in the survival (p = 0.05) and the development of severe GVHD (p = 0.0007) in recipients of RD marrow. One HLA-DRB1 allele mismatch was associated only with a decrease in the survival (p = 0.0003) of recipients of RD marrow. Results of this study suggest that disparity in HLA-A and HLA-B antigens may not be better tolerated than disparity in HLA-DR allele in allogeneic BMT. Further studies are warranted to confirm our results. © American Society for Histocompatibility and Immunogenetics, 2001. Published by Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/294379
ISSN
2020 Impact Factor: 2.85
2020 SCImago Journal Rankings: 0.908
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, Wing H.-
dc.contributor.authorTurner, Victoria-
dc.contributor.authorRichardson, Stacye L.-
dc.contributor.authorBenaim, Ely-
dc.contributor.authorHale, Gregory-
dc.contributor.authorHorwitz, Edwin M.-
dc.contributor.authorWoodard, Paul-
dc.contributor.authorBowman, Laura C.-
dc.date.accessioned2020-12-03T08:22:36Z-
dc.date.available2020-12-03T08:22:36Z-
dc.date.issued2001-
dc.identifier.citationHuman Immunology, 2001, v. 62, n. 4, p. 399-407-
dc.identifier.issn0198-8859-
dc.identifier.urihttp://hdl.handle.net/10722/294379-
dc.description.abstractThe degree of histoincompatibility that can be tolerated, and the relative importance of matching at individual HLA class I and class II locus in bone marrow transplantation (BMT) has not been established. We hypothesized that matching for HLA-DR may not be more important than matching for HLA-A or HLA-B in selection of a donor for successful BMT. We retrospectively analyzed the outcomes of 248 consecutive pediatric patients who received allogeneic BMT from related donors (RD, n = 119) or unrelated donors (URD, n = 129). HLA-A and HLA-B were serologically matched, and HLA-DRB1 were identical by DNA typing in 69% of donor-recipient pairs. Most patients (89%) had hematologic malignancies; the rest had aplastic anemia or a congenital disorder. One HLA-A antigen mismatch was associated with a decrease in survival (p = 0.003) and a delay in granulocyte engraftment (p = 0.02) in recipients of RD marrow; as well as a decrease in survival (p = 0.02) and the development of severe acute graft-versus-host disease (GVHD) (p = 0.03) in recipients of URD marrow. One HLA-B antigen mismatch was associated with a decrease in the survival (p = 0.05) and the development of severe GVHD (p = 0.0007) in recipients of RD marrow. One HLA-DRB1 allele mismatch was associated only with a decrease in the survival (p = 0.0003) of recipients of RD marrow. Results of this study suggest that disparity in HLA-A and HLA-B antigens may not be better tolerated than disparity in HLA-DR allele in allogeneic BMT. Further studies are warranted to confirm our results. © American Society for Histocompatibility and Immunogenetics, 2001. Published by Elsevier Science Inc.-
dc.languageeng-
dc.relation.ispartofHuman Immunology-
dc.subjectBone marrow transplantation-
dc.subjectPediatric-
dc.subjectHLA-
dc.titleEffect of HLA class I or class II incompatibility in pediatric marrow transplantation from unrelated and related donors-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0198-8859(01)00220-8-
dc.identifier.pmid11295473-
dc.identifier.scopuseid_2-s2.0-0035049030-
dc.identifier.volume62-
dc.identifier.issue4-
dc.identifier.spage399-
dc.identifier.epage407-
dc.identifier.isiWOS:000168062900012-
dc.identifier.issnl0198-8859-

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