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Article: Tumour cell contamination of autologous stem cells grafts in high-risk neuroblastoma: The good news?

TitleTumour cell contamination of autologous stem cells grafts in high-risk neuroblastoma: The good news?
Authors
Handgretinger, R.Leung, W.Ihm, K.Lang, P.Klingebiel, T.Niethammer, D.
KeywordsCD34 selection
Lymphodepletion
Neuroblastoma
T-cell homeostatic proliferation
High-dose chemotherapy
Issue Date2003
Citation
British Journal of Cancer, 2003, v. 88, n. 12, p. 1874-1877 How to Cite?
DOI: http://dx.doi.org/10.1038/sj.bjc.6601014
AbstractWe analysed the effect of graft-contaminating tumour cells on the long-term survival of 24 patients with high-risk neurobtastoma and found that patients whose grafts contained detectable neuroblastoma cells had a significantly higher probability of survival than did patients with no detectable tumour cells. Estimated contamination of the graft by more than 2000 tumour cells was associated with a significantly higher probability of survival than contamination with fewer tumour cells. We hypothesise that the presence of a critical number of graft-contaminating neuroblastoma cells can elicit a protective antitumour immune response after autologous transplantation. © 2003 Cancer Research UK.
Persistent Identifierhttp://hdl.handle.net/10722/294392
ISSN
0007-0920
2023 Impact Factor: 6.4
2023 SCImago Journal Rankings: 3.000
PubMed Central ID
PMC2741120
ISI Accession Number ID
WOS:000183729200009

 

DC FieldValueLanguage
dc.contributor.authorHandgretinger, R.-
dc.contributor.authorLeung, W.-
dc.contributor.authorIhm, K.-
dc.contributor.authorLang, P.-
dc.contributor.authorKlingebiel, T.-
dc.contributor.authorNiethammer, D.-
dc.date.accessioned2020-12-03T08:22:38Z-
dc.date.available2020-12-03T08:22:38Z-
dc.date.issued2003-
dc.identifier.citationBritish Journal of Cancer, 2003, v. 88, n. 12, p. 1874-1877-
dc.identifier.issn0007-0920-
dc.identifier.urihttp://hdl.handle.net/10722/294392-
dc.description.abstractWe analysed the effect of graft-contaminating tumour cells on the long-term survival of 24 patients with high-risk neurobtastoma and found that patients whose grafts contained detectable neuroblastoma cells had a significantly higher probability of survival than did patients with no detectable tumour cells. Estimated contamination of the graft by more than 2000 tumour cells was associated with a significantly higher probability of survival than contamination with fewer tumour cells. We hypothesise that the presence of a critical number of graft-contaminating neuroblastoma cells can elicit a protective antitumour immune response after autologous transplantation. © 2003 Cancer Research UK.-
dc.languageeng-
dc.relation.ispartofBritish Journal of Cancer-
dc.subjectCD34 selection-
dc.subjectLymphodepletion-
dc.subjectNeuroblastoma-
dc.subjectT-cell homeostatic proliferation-
dc.subjectHigh-dose chemotherapy-
dc.titleTumour cell contamination of autologous stem cells grafts in high-risk neuroblastoma: The good news?-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/sj.bjc.6601014-
dc.identifier.pmid12799629-
dc.identifier.pmcidPMC2741120-
dc.identifier.scopuseid_2-s2.0-0037899030-
dc.identifier.volume88-
dc.identifier.issue12-
dc.identifier.spage1874-
dc.identifier.epage1877-
dc.identifier.isiWOS:000183729200009-
dc.identifier.issnl0007-0920-

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