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Article: T-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation

TitleT-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation
Authors
KeywordsNatural killer cells
Bone marrow transplantation
Paediatric
Human leucocyte antigen (HLA)
Issue Date2003
Citation
British Journal of Haematology, 2003, v. 123, n. 2, p. 323-326 How to Cite?
AbstractNatural killer (NK) cell alloreactivity resulting from killer immunoglobulin-like receptor (KIR) ligand incompatibility improves outcomes in patients receiving extensively T-cell-depleted bone marrow (BM) grafts. Patients with KIR ligand incompatibility are at risk for donor T-cell alloreactivity. We investigated the relative significance of NK-cell and T-cell alloreactivity in 105 paediatric patients who received a minimally T-cell-depleted human leucocyte antigen-non-identical BM transplantation. Donor NK-cell incompatibility did not improve patient outcome [engraftment, graft-versus-host disease (GVHD), relapse or overall survival]. In contrast, donor T-cell incompatibility was a risk factor for acute GVHD, chronic GVHD and death. Thus, T-cell alloreactivity dominated that of NK cells in minimally T-cell-depleted grafts.
Persistent Identifierhttp://hdl.handle.net/10722/294394
ISSN
2020 Impact Factor: 6.998
2020 SCImago Journal Rankings: 1.907
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLowe, Eric J.-
dc.contributor.authorTurner, Victoria-
dc.contributor.authorHandgretinger, Rupert-
dc.contributor.authorHorwitz, Edwin M.-
dc.contributor.authorBenaim, Ely-
dc.contributor.authorHale, Gregory A.-
dc.contributor.authorWooard, Paul-
dc.contributor.authorLeung, Wing-
dc.date.accessioned2020-12-03T08:22:38Z-
dc.date.available2020-12-03T08:22:38Z-
dc.date.issued2003-
dc.identifier.citationBritish Journal of Haematology, 2003, v. 123, n. 2, p. 323-326-
dc.identifier.issn0007-1048-
dc.identifier.urihttp://hdl.handle.net/10722/294394-
dc.description.abstractNatural killer (NK) cell alloreactivity resulting from killer immunoglobulin-like receptor (KIR) ligand incompatibility improves outcomes in patients receiving extensively T-cell-depleted bone marrow (BM) grafts. Patients with KIR ligand incompatibility are at risk for donor T-cell alloreactivity. We investigated the relative significance of NK-cell and T-cell alloreactivity in 105 paediatric patients who received a minimally T-cell-depleted human leucocyte antigen-non-identical BM transplantation. Donor NK-cell incompatibility did not improve patient outcome [engraftment, graft-versus-host disease (GVHD), relapse or overall survival]. In contrast, donor T-cell incompatibility was a risk factor for acute GVHD, chronic GVHD and death. Thus, T-cell alloreactivity dominated that of NK cells in minimally T-cell-depleted grafts.-
dc.languageeng-
dc.relation.ispartofBritish Journal of Haematology-
dc.subjectNatural killer cells-
dc.subjectBone marrow transplantation-
dc.subjectPaediatric-
dc.subjectHuman leucocyte antigen (HLA)-
dc.titleT-cell alloreactivity dominates natural killer cell alloreactivity in minimally T-cell-depleted HLA-non-identical paediatric bone marrow transplantation-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1046/j.1365-2141.2003.04604.x-
dc.identifier.pmid14531915-
dc.identifier.scopuseid_2-s2.0-0142215546-
dc.identifier.volume123-
dc.identifier.issue2-
dc.identifier.spage323-
dc.identifier.epage326-
dc.identifier.isiWOS:000185779500015-
dc.identifier.issnl0007-1048-

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