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Article: Possible Allogeneic Graft-Versus-Tumor Effect in Childhood Melanoma

TitlePossible Allogeneic Graft-Versus-Tumor Effect in Childhood Melanoma
Authors
KeywordsGraft-versus-tumor effect
Hematopoietic stem cell transplantation
Melanoma
Issue Date2003
Citation
Journal of Pediatric Hematology/Oncology, 2003, v. 25, n. 12, p. 982-986 How to Cite?
AbstractPatients with metastatic melanoma have a very poor prognosis despite contemporary biochemotherapy. A 14-year-old girl with stage IV melanoma and brain metastasis received a nonmyeloablative conditioning and a hematopoietic graft from an HLA-identical sibling. She had progression of disease in the first 2 months after transplantation. After withdrawal of immunosuppressant and establishment of a full donor chimeric status, peripheral disease response was documented by regression of metastatic disease and lack of tumor progression until 1 year after transplantation. She died of progressive disease 21 months after diagnosis and 17 months after transplantation. Her clinical course suggested the possible existence of an allogeneic graft-versus-melanoma response that prolonged her survival.
Persistent Identifierhttp://hdl.handle.net/10722/294398
ISSN
2021 Impact Factor: 1.170
2020 SCImago Journal Rankings: 0.388
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKasow, Kimberly A.-
dc.contributor.authorHandgretinger, Rupert-
dc.contributor.authorKrasin, Matthew J.-
dc.contributor.authorPappo, Alberto S.-
dc.contributor.authorLeung, Wing-
dc.date.accessioned2020-12-03T08:22:38Z-
dc.date.available2020-12-03T08:22:38Z-
dc.date.issued2003-
dc.identifier.citationJournal of Pediatric Hematology/Oncology, 2003, v. 25, n. 12, p. 982-986-
dc.identifier.issn1077-4114-
dc.identifier.urihttp://hdl.handle.net/10722/294398-
dc.description.abstractPatients with metastatic melanoma have a very poor prognosis despite contemporary biochemotherapy. A 14-year-old girl with stage IV melanoma and brain metastasis received a nonmyeloablative conditioning and a hematopoietic graft from an HLA-identical sibling. She had progression of disease in the first 2 months after transplantation. After withdrawal of immunosuppressant and establishment of a full donor chimeric status, peripheral disease response was documented by regression of metastatic disease and lack of tumor progression until 1 year after transplantation. She died of progressive disease 21 months after diagnosis and 17 months after transplantation. Her clinical course suggested the possible existence of an allogeneic graft-versus-melanoma response that prolonged her survival.-
dc.languageeng-
dc.relation.ispartofJournal of Pediatric Hematology/Oncology-
dc.subjectGraft-versus-tumor effect-
dc.subjectHematopoietic stem cell transplantation-
dc.subjectMelanoma-
dc.titlePossible Allogeneic Graft-Versus-Tumor Effect in Childhood Melanoma-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00043426-200312000-00016-
dc.identifier.pmid14663285-
dc.identifier.scopuseid_2-s2.0-0347383978-
dc.identifier.volume25-
dc.identifier.issue12-
dc.identifier.spage982-
dc.identifier.epage986-
dc.identifier.isiWOS:000187208200013-
dc.identifier.issnl1077-4114-

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