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Article: Etiology and Outcome of Graft Failure in Pediatric Hematopoietic Stem Cell Transplant Recipients

TitleEtiology and Outcome of Graft Failure in Pediatric Hematopoietic Stem Cell Transplant Recipients
Authors
KeywordsRejection
Graft failure
Allogeneic bone marrow transplantation
Issue Date2003
Citation
Journal of Pediatric Hematology/Oncology, 2003, v. 25, n. 12, p. 955-959 How to Cite?
AbstractPurpose: To determine the incidence, etiology and outcome of graft failure in pediatric allogeneic bone marrow transplant (BMT) recipients. Patients and Methods: Patients with primary or secondary graft failure were identified by database review. A retrospective chart review was performed. Etiologic factors were identified and assessed for statistical significance. Results: 309 children underwent allogeneic BMT during the time interval studied. Four cases of primary graft failure and 7 cases of secondary graft failure occurred. Nonmalignant diagnosis, lower total nucleated cell (TNC) dose, and conditioning without total body irradiation were associated with a higher incidence of graft failure. Donor source, donor/recipient CMV status, CD34+ cell dose, and alloimmunization were not associated with graft failure. Conclusions: Graft failure is a relatively uncommon occurrence in pediatric patients. Autologous reinfusion may allow time to prepare the patient for a second transplant and decrease complications associated with aplasia. More immunosuppressive conditioning regimens may decrease the incidence of graft failure, particularly in patients with non-malignant diseases or those with lower stem cell doses. More frequent monitoring of chimerism by VNTR analysis may detect late graft failure earlier and allow for more rapid intervention.
Persistent Identifierhttp://hdl.handle.net/10722/294399
ISSN
2020 Impact Factor: 1.289
2020 SCImago Journal Rankings: 0.388
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWoodard, Paul-
dc.contributor.authorTong, Xin-
dc.contributor.authorRichardson, Stacye-
dc.contributor.authorSrivastava, Deo Kumar-
dc.contributor.authorHorwitz, Edwin M.-
dc.contributor.authorBenaim, Ely-
dc.contributor.authorGeiger, Terrence-
dc.contributor.authorHale, Gregory-
dc.contributor.authorLeung, Wing-
dc.contributor.authorTurner, Victoria-
dc.contributor.authorYusuf, Usman-
dc.contributor.authorCunningham, John-
dc.contributor.authorHandgretinger, Rupert-
dc.date.accessioned2020-12-03T08:22:38Z-
dc.date.available2020-12-03T08:22:38Z-
dc.date.issued2003-
dc.identifier.citationJournal of Pediatric Hematology/Oncology, 2003, v. 25, n. 12, p. 955-959-
dc.identifier.issn1077-4114-
dc.identifier.urihttp://hdl.handle.net/10722/294399-
dc.description.abstractPurpose: To determine the incidence, etiology and outcome of graft failure in pediatric allogeneic bone marrow transplant (BMT) recipients. Patients and Methods: Patients with primary or secondary graft failure were identified by database review. A retrospective chart review was performed. Etiologic factors were identified and assessed for statistical significance. Results: 309 children underwent allogeneic BMT during the time interval studied. Four cases of primary graft failure and 7 cases of secondary graft failure occurred. Nonmalignant diagnosis, lower total nucleated cell (TNC) dose, and conditioning without total body irradiation were associated with a higher incidence of graft failure. Donor source, donor/recipient CMV status, CD34+ cell dose, and alloimmunization were not associated with graft failure. Conclusions: Graft failure is a relatively uncommon occurrence in pediatric patients. Autologous reinfusion may allow time to prepare the patient for a second transplant and decrease complications associated with aplasia. More immunosuppressive conditioning regimens may decrease the incidence of graft failure, particularly in patients with non-malignant diseases or those with lower stem cell doses. More frequent monitoring of chimerism by VNTR analysis may detect late graft failure earlier and allow for more rapid intervention.-
dc.languageeng-
dc.relation.ispartofJournal of Pediatric Hematology/Oncology-
dc.subjectRejection-
dc.subjectGraft failure-
dc.subjectAllogeneic bone marrow transplantation-
dc.titleEtiology and Outcome of Graft Failure in Pediatric Hematopoietic Stem Cell Transplant Recipients-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00043426-200312000-00010-
dc.identifier.pmid14663279-
dc.identifier.scopuseid_2-s2.0-10744221045-
dc.identifier.volume25-
dc.identifier.issue12-
dc.identifier.spage955-
dc.identifier.epage959-
dc.identifier.isiWOS:000187208200007-
dc.identifier.issnl1077-4114-

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