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Article: Cyclooxygenase-2 Inhibition to Treat Radiation-Induced Brain Necrosis and Edema

TitleCyclooxygenase-2 Inhibition to Treat Radiation-Induced Brain Necrosis and Edema
Authors
KeywordsBrain necrosis
Radiosurgery
Cyclooxygenase-2
Issue Date2004
Citation
Journal of Pediatric Hematology/Oncology, 2004, v. 26, n. 4, p. 253-255 How to Cite?
AbstractBrain necrosis and edema develop in a proportion of brain tumor patients treated with radiosurgery. Surgical resection and corticosteroids have considerable morbidity. Two metastatic melanoma brain lesions in a 14-year-old girl were treated with radiosurgery and whole-brain radiation treatment. Both lesions became symptomatic from radiologic features of necrosis and edema and were unresponsive to oral corticosteroids. The larger lesion was resected, but the other lesion continued to enlarge. Cyclooxygenase-2 (COX-2) inhibitor was started, and the child improved clinically and radiologically. The usefulness of COX-2 inhibitors in treating radiation necrosis and edema, as suggested by this report, requires further study.
Persistent Identifierhttp://hdl.handle.net/10722/294403
ISSN
2021 Impact Factor: 1.170
2020 SCImago Journal Rankings: 0.388
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKhan, Raja B.-
dc.contributor.authorKrasin, Matthew J.-
dc.contributor.authorKasow, Kimberly-
dc.contributor.authorLeung, Wing-
dc.date.accessioned2020-12-03T08:22:39Z-
dc.date.available2020-12-03T08:22:39Z-
dc.date.issued2004-
dc.identifier.citationJournal of Pediatric Hematology/Oncology, 2004, v. 26, n. 4, p. 253-255-
dc.identifier.issn1077-4114-
dc.identifier.urihttp://hdl.handle.net/10722/294403-
dc.description.abstractBrain necrosis and edema develop in a proportion of brain tumor patients treated with radiosurgery. Surgical resection and corticosteroids have considerable morbidity. Two metastatic melanoma brain lesions in a 14-year-old girl were treated with radiosurgery and whole-brain radiation treatment. Both lesions became symptomatic from radiologic features of necrosis and edema and were unresponsive to oral corticosteroids. The larger lesion was resected, but the other lesion continued to enlarge. Cyclooxygenase-2 (COX-2) inhibitor was started, and the child improved clinically and radiologically. The usefulness of COX-2 inhibitors in treating radiation necrosis and edema, as suggested by this report, requires further study.-
dc.languageeng-
dc.relation.ispartofJournal of Pediatric Hematology/Oncology-
dc.subjectBrain necrosis-
dc.subjectRadiosurgery-
dc.subjectCyclooxygenase-2-
dc.titleCyclooxygenase-2 Inhibition to Treat Radiation-Induced Brain Necrosis and Edema-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/00043426-200404000-00008-
dc.identifier.pmid15087954-
dc.identifier.scopuseid_2-s2.0-16544372152-
dc.identifier.volume26-
dc.identifier.issue4-
dc.identifier.spage253-
dc.identifier.epage255-
dc.identifier.isiWOS:000220776500008-
dc.identifier.issnl1077-4114-

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