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Article: Iron overload in survivors of childhood leukemia after allogeneic hematopoietic stem cell transplantation

TitleIron overload in survivors of childhood leukemia after allogeneic hematopoietic stem cell transplantation
Authors
KeywordsIron overload
Allogeneic hematopoietic stem cell transplantation
Childhood leukemia
Issue Date2009
Citation
Pediatric Transplantation, 2009, v. 13, n. 3, p. 348-352 How to Cite?
AbstractIron overload has not been studied extensively and prospectively in pediatric survivors of allogeneic hematopoietic stem cell transplantation (HSCT); therefore, we conducted a prospective longterm study of 133 survivors of childhood leukemia to assess the incidence of and risk factors for iron overload and to investigate its association with organ dysfunction. One yr after HSCT, the mean serum ferritin level was 1158 ng/mL (range, 22-3264 ng/mL), with 124 patients (93.2%) having a serum ferritin level that exceeded the upper limit of the normal range (110 ng/mL). Thereafter, the serum ferritin level declined over time. There was a positive correlation between the level of serum ferritin and that of total bilirubin (r = 0.21, p < 0.001) and glutamate pyruvate transaminase (r = 0.17, p < 0.001). A high concentration of serum ferritin was associated with low cardiac fractional shortening (r = )0.15, p = 0.047). In addition, patients with hypothyroidism and GH deficiency had a higher level of serum ferritin than those without (p < 0.02). We conclude that iron overload is common after HSCT and is associated with hepatic, cardiac, and endocrine dysfunction. © 2008 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/294427
ISSN
2020 Impact Factor: 1.502
2020 SCImago Journal Rankings: 0.457
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChotsampancharoen, Thirachit-
dc.contributor.authorGan, Kwan-
dc.contributor.authorKasow, Kimberly A.-
dc.contributor.authorBarfield, Raymond C.-
dc.contributor.authorHale, Gregory A.-
dc.contributor.authorLeung, Wing-
dc.date.accessioned2020-12-03T08:22:42Z-
dc.date.available2020-12-03T08:22:42Z-
dc.date.issued2009-
dc.identifier.citationPediatric Transplantation, 2009, v. 13, n. 3, p. 348-352-
dc.identifier.issn1397-3142-
dc.identifier.urihttp://hdl.handle.net/10722/294427-
dc.description.abstractIron overload has not been studied extensively and prospectively in pediatric survivors of allogeneic hematopoietic stem cell transplantation (HSCT); therefore, we conducted a prospective longterm study of 133 survivors of childhood leukemia to assess the incidence of and risk factors for iron overload and to investigate its association with organ dysfunction. One yr after HSCT, the mean serum ferritin level was 1158 ng/mL (range, 22-3264 ng/mL), with 124 patients (93.2%) having a serum ferritin level that exceeded the upper limit of the normal range (110 ng/mL). Thereafter, the serum ferritin level declined over time. There was a positive correlation between the level of serum ferritin and that of total bilirubin (r = 0.21, p < 0.001) and glutamate pyruvate transaminase (r = 0.17, p < 0.001). A high concentration of serum ferritin was associated with low cardiac fractional shortening (r = )0.15, p = 0.047). In addition, patients with hypothyroidism and GH deficiency had a higher level of serum ferritin than those without (p < 0.02). We conclude that iron overload is common after HSCT and is associated with hepatic, cardiac, and endocrine dysfunction. © 2008 John Wiley & Sons A/S.-
dc.languageeng-
dc.relation.ispartofPediatric Transplantation-
dc.subjectIron overload-
dc.subjectAllogeneic hematopoietic stem cell transplantation-
dc.subjectChildhood leukemia-
dc.titleIron overload in survivors of childhood leukemia after allogeneic hematopoietic stem cell transplantation-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1399-3046.2008.00983.x-
dc.identifier.pmid18518909-
dc.identifier.scopuseid_2-s2.0-64149086833-
dc.identifier.volume13-
dc.identifier.issue3-
dc.identifier.spage348-
dc.identifier.epage352-
dc.identifier.eissn1399-3046-
dc.identifier.isiWOS:000264891700015-
dc.identifier.issnl1397-3142-

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