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Article: KIR-HLA receptor-ligand mismatch associated with a graft-versus-tumor effect in haploidentical stem cell transplantation for pediatric metastatic solid tumors

TitleKIR-HLA receptor-ligand mismatch associated with a graft-versus-tumor effect in haploidentical stem cell transplantation for pediatric metastatic solid tumors
Authors
KeywordsKIR-HLA mismatch
Pediatric solid tumors
NK cells
Haploidentical stem cell transplantation
Issue Date2009
Citation
Pediatric Blood and Cancer, 2009, v. 53, n. 1, p. 120-124 How to Cite?
AbstractKiller immunoglobulin-like receptors (KIRs) on natural killer cells (NKs) recognize groups of human leukocyte antigen (HLA) class I alleles. Cells without an inhibitory HLA ligand may trigger NK activation. Reduced risk of relapse has been reported in malignant hematologic diseases after haploidentical transplantation when HLA ligands against the inhibitory KIRs present in the donor were absent in the recipient. We performed haploidentical transplant in three children with refractory solid tumors. Our results showed that beneficial antitumor effects could be observed in the presence of inhibitory KIR-HLA mismatch. These preliminary results suggest a possible association between disease control and NK cell alloreactivity. © 2009 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/294429
ISSN
2020 Impact Factor: 3.167
2020 SCImago Journal Rankings: 1.116
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPérez-Martínez, Antonio-
dc.contributor.authorLeung, Wing-
dc.contributor.authorMuñoz, Evangelina-
dc.contributor.authorIyengar, Rekha-
dc.contributor.authorRamírez, Manuel-
dc.contributor.authorVicario, José Luis-
dc.contributor.authorLassaletta, Álvaro-
dc.contributor.authorSevilla, Julián-
dc.contributor.authorGonzález-Vicent, Marta-
dc.contributor.authorMadero, Luis-
dc.contributor.authorDíaz-Pérez, Miguel Ángel-
dc.date.accessioned2020-12-03T08:22:43Z-
dc.date.available2020-12-03T08:22:43Z-
dc.date.issued2009-
dc.identifier.citationPediatric Blood and Cancer, 2009, v. 53, n. 1, p. 120-124-
dc.identifier.issn1545-5009-
dc.identifier.urihttp://hdl.handle.net/10722/294429-
dc.description.abstractKiller immunoglobulin-like receptors (KIRs) on natural killer cells (NKs) recognize groups of human leukocyte antigen (HLA) class I alleles. Cells without an inhibitory HLA ligand may trigger NK activation. Reduced risk of relapse has been reported in malignant hematologic diseases after haploidentical transplantation when HLA ligands against the inhibitory KIRs present in the donor were absent in the recipient. We performed haploidentical transplant in three children with refractory solid tumors. Our results showed that beneficial antitumor effects could be observed in the presence of inhibitory KIR-HLA mismatch. These preliminary results suggest a possible association between disease control and NK cell alloreactivity. © 2009 Wiley-Liss, Inc.-
dc.languageeng-
dc.relation.ispartofPediatric Blood and Cancer-
dc.subjectKIR-HLA mismatch-
dc.subjectPediatric solid tumors-
dc.subjectNK cells-
dc.subjectHaploidentical stem cell transplantation-
dc.titleKIR-HLA receptor-ligand mismatch associated with a graft-versus-tumor effect in haploidentical stem cell transplantation for pediatric metastatic solid tumors-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/pbc.21955-
dc.identifier.pmid19215002-
dc.identifier.scopuseid_2-s2.0-66149091543-
dc.identifier.volume53-
dc.identifier.issue1-
dc.identifier.spage120-
dc.identifier.epage124-
dc.identifier.eissn1545-5017-
dc.identifier.isiWOS:000266186200029-
dc.identifier.issnl1545-5009-

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