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Article: Pulmonary dysfunction in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem cell transplantation

TitlePulmonary dysfunction in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem cell transplantation
Authors
KeywordsHematopoietic stem cell transplantation
Leukemia
Childhood
Pulmonary function
Survivor
Issue Date2010
Citation
Cancer, 2010, v. 116, n. 8, p. 2020-2030 How to Cite?
AbstractThe number of long-term survivors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is increasing; however, few studies have addressed their long-term pulmonary function. METHODS: The authors examined 660 baseline and follow-up pulmonary function tests in 89 long-term survivors of pediatric hematologic malignancies and allo-HSCT. RESULTS: At least 1 abnormal lung parameter was seen in 40.4% of baseline tests and developed in 64% of post-allo-HSCT tests (median follow-up: 8.9 years). Abnormal baseline values in ratio of forced expiratory volume in 1 second and forced vital capacity (FEV1/FVC), FEV1, residual volume (RV), functional residual capacity (FRC), and FVC were associated with abnormal post-allo-HSCT values. The following pulmonary function values declined significantly with time: FEV1/FVC, forced mid-expiratory flow (FEF25%-75%), total lung capacity (TLC), diffusion capacity corrected for hemoglobin (DLCO corr), RV, FRC, and RV/TLC. Older age at the time of allo-HSCT was associated with lower FEV1/FVC, FEF25%-75%, and DLCOcorr and higher RV/TLC. Patients who experienced respiratory events within 1 year post-allo-HSCT had lower FEV1 and FVC values and higher RV/TLC from their baseline pulmonary function tests. Female patients had reduced FVC, TLC, and RV values but higher FEV1/FVC. Pulmonary dysfunction was also associated with high-risk hematological malignancies and peripheral blood HSC product. CONCLUSIONS: Abnormal pulmonary functions in allo-HSCT survivors are prevalent, which underscore the need for risk-adapted continual monitoring and improved preventive and management strategies. © 2010 American Cancer Society.
Persistent Identifierhttp://hdl.handle.net/10722/294434
ISSN
2020 Impact Factor: 6.86
2020 SCImago Journal Rankings: 3.052
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorInaba, Hiroto-
dc.contributor.authorYang, Jie-
dc.contributor.authorPan, Jianmin-
dc.contributor.authorStokes, Dennis C.-
dc.contributor.authorKrasin, Matthew J.-
dc.contributor.authorSrinivasan, Ashok-
dc.contributor.authorHartford, Christine M.-
dc.contributor.authorPui, Ching Hon-
dc.contributor.authorLeung, Wing-
dc.date.accessioned2020-12-03T08:22:43Z-
dc.date.available2020-12-03T08:22:43Z-
dc.date.issued2010-
dc.identifier.citationCancer, 2010, v. 116, n. 8, p. 2020-2030-
dc.identifier.issn0008-543X-
dc.identifier.urihttp://hdl.handle.net/10722/294434-
dc.description.abstractThe number of long-term survivors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is increasing; however, few studies have addressed their long-term pulmonary function. METHODS: The authors examined 660 baseline and follow-up pulmonary function tests in 89 long-term survivors of pediatric hematologic malignancies and allo-HSCT. RESULTS: At least 1 abnormal lung parameter was seen in 40.4% of baseline tests and developed in 64% of post-allo-HSCT tests (median follow-up: 8.9 years). Abnormal baseline values in ratio of forced expiratory volume in 1 second and forced vital capacity (FEV1/FVC), FEV1, residual volume (RV), functional residual capacity (FRC), and FVC were associated with abnormal post-allo-HSCT values. The following pulmonary function values declined significantly with time: FEV1/FVC, forced mid-expiratory flow (FEF25%-75%), total lung capacity (TLC), diffusion capacity corrected for hemoglobin (DLCO corr), RV, FRC, and RV/TLC. Older age at the time of allo-HSCT was associated with lower FEV1/FVC, FEF25%-75%, and DLCOcorr and higher RV/TLC. Patients who experienced respiratory events within 1 year post-allo-HSCT had lower FEV1 and FVC values and higher RV/TLC from their baseline pulmonary function tests. Female patients had reduced FVC, TLC, and RV values but higher FEV1/FVC. Pulmonary dysfunction was also associated with high-risk hematological malignancies and peripheral blood HSC product. CONCLUSIONS: Abnormal pulmonary functions in allo-HSCT survivors are prevalent, which underscore the need for risk-adapted continual monitoring and improved preventive and management strategies. © 2010 American Cancer Society.-
dc.languageeng-
dc.relation.ispartofCancer-
dc.subjectHematopoietic stem cell transplantation-
dc.subjectLeukemia-
dc.subjectChildhood-
dc.subjectPulmonary function-
dc.subjectSurvivor-
dc.titlePulmonary dysfunction in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem cell transplantation-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/cncr.24897-
dc.identifier.pmid20186702-
dc.identifier.pmcidPMC2919832-
dc.identifier.scopuseid_2-s2.0-77950965525-
dc.identifier.volume116-
dc.identifier.issue8-
dc.identifier.spage2020-
dc.identifier.epage2030-
dc.identifier.eissn1097-0142-
dc.identifier.isiWOS:000276584700023-
dc.identifier.issnl0008-543X-

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