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Article: Molecular determinant-based typing of KIR alleles and KIR ligands

TitleMolecular determinant-based typing of KIR alleles and KIR ligands
Authors
KeywordsKiller cell immunoglobulin-like receptor
Human leukocyte antigen
Natural killer cell
Single-nucleotide polymorphism
Issue Date2011
Citation
Clinical Immunology, 2011, v. 138, n. 3, p. 274-281 How to Cite?
AbstractKiller cell immunoglobulin-like receptors (KIRs) regulate NK cell function. KIRs and their HLA ligands are highly polymorphic in nature with substantial allelic polymorphism. At present, there is a lack of an expedient method for KIR and HLA allele typing with relevant functional information. Here, we developed a single-nucleotide polymorphism (SNP) assay to type various allele groups of KIR2DL1 with distinct functional properties based on polymorphism at position 245. We also established a SNP assay to type different KIR ligands based on polymorphism at position 77 in HLA-C and position 83 in HLA-B and -A. Our SNP assays for KIR and KIR ligand typing are much cheaper and faster than existing high-resolution typing. Importantly, our high-throughput methods provide readouts that are informative in predicting NK cell activity in health, disease, and transplantation. © 2010 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/294438
ISSN
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.359
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBari, Rafijul-
dc.contributor.authorLeung, Matthias-
dc.contributor.authorTurner, Victoria E.-
dc.contributor.authorEmbrey, Christy-
dc.contributor.authorRooney, Barbara-
dc.contributor.authorHolladay, Martha-
dc.contributor.authorLeung, Wing-
dc.date.accessioned2020-12-03T08:22:44Z-
dc.date.available2020-12-03T08:22:44Z-
dc.date.issued2011-
dc.identifier.citationClinical Immunology, 2011, v. 138, n. 3, p. 274-281-
dc.identifier.issn1521-6616-
dc.identifier.urihttp://hdl.handle.net/10722/294438-
dc.description.abstractKiller cell immunoglobulin-like receptors (KIRs) regulate NK cell function. KIRs and their HLA ligands are highly polymorphic in nature with substantial allelic polymorphism. At present, there is a lack of an expedient method for KIR and HLA allele typing with relevant functional information. Here, we developed a single-nucleotide polymorphism (SNP) assay to type various allele groups of KIR2DL1 with distinct functional properties based on polymorphism at position 245. We also established a SNP assay to type different KIR ligands based on polymorphism at position 77 in HLA-C and position 83 in HLA-B and -A. Our SNP assays for KIR and KIR ligand typing are much cheaper and faster than existing high-resolution typing. Importantly, our high-throughput methods provide readouts that are informative in predicting NK cell activity in health, disease, and transplantation. © 2010 Elsevier Inc.-
dc.languageeng-
dc.relation.ispartofClinical Immunology-
dc.subjectKiller cell immunoglobulin-like receptor-
dc.subjectHuman leukocyte antigen-
dc.subjectNatural killer cell-
dc.subjectSingle-nucleotide polymorphism-
dc.titleMolecular determinant-based typing of KIR alleles and KIR ligands-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.clim.2010.12.002-
dc.identifier.pmid21239231-
dc.identifier.pmcidPMC4733522-
dc.identifier.scopuseid_2-s2.0-79851508022-
dc.identifier.volume138-
dc.identifier.issue3-
dc.identifier.spage274-
dc.identifier.epage281-
dc.identifier.eissn1521-7035-
dc.identifier.isiWOS:000287683300005-
dc.identifier.issnl1521-6616-

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