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Article: Blood Dendritic Cells Suppress NK Cell Function and Increase the Risk of Leukemia Relapse after Hematopoietic Cell Transplantation

TitleBlood Dendritic Cells Suppress NK Cell Function and Increase the Risk of Leukemia Relapse after Hematopoietic Cell Transplantation
Authors
KeywordsCendritic cell
Pediatric leukemia
Human nK cell
Alloegenic hematopoietic cell transplantation
Issue Date2011
Citation
Biology of Blood and Marrow Transplantation, 2011, v. 17, n. 5, p. 598-607 How to Cite?
AbstractNK cells play an important role in hematopoietic stem cell transplantation (HCT) and in cross talk with dendritic cells (DCs) to induce primary T cell response against infection. Therefore, we hypothesized that blood DCs should augment NK cell function and reduce the risk of leukemia relapse after HCT. To test this hypothesis, we conducted laboratory and clinical studies in parallel. We found that although, phenotypically, NK cells could induce DC maturation and DCs could in turn increase activating marker expression on NK cells, paradoxically, both BDCA1+ myeloid DCs and BDCA4+ plasmacytoid DCs suppressed the function of NK cells. Patients who received an HLA-haploidentical graft containing a larger number of BDCA1+ DCs or BDCA4+ DCs had a higher risk of leukemia relapse and poorer survival. Further experiments indicated that the potent inhibition on NK cell cytokine production and cytotoxicity was mediated in part through the secretion of IL-10 by BDCA1+ DCs and IL-6 by BDCA4+ DCs. These results have significant implications for future HCT strategies. © 2011 American Society for Blood and Marrow Transplantation.
Persistent Identifierhttp://hdl.handle.net/10722/294440
ISSN
2020 Impact Factor: 5.742
2020 SCImago Journal Rankings: 2.301
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPerez-Martinez, Antonio-
dc.contributor.authorIyengar, Rekha-
dc.contributor.authorGan, Kwan-
dc.contributor.authorChotsampancharoen, Thirachit-
dc.contributor.authorRooney, Barbara-
dc.contributor.authorHolladay, Marti-
dc.contributor.authorRamírez, Manuel-
dc.contributor.authorLeung, Wing-
dc.date.accessioned2020-12-03T08:22:44Z-
dc.date.available2020-12-03T08:22:44Z-
dc.date.issued2011-
dc.identifier.citationBiology of Blood and Marrow Transplantation, 2011, v. 17, n. 5, p. 598-607-
dc.identifier.issn1083-8791-
dc.identifier.urihttp://hdl.handle.net/10722/294440-
dc.description.abstractNK cells play an important role in hematopoietic stem cell transplantation (HCT) and in cross talk with dendritic cells (DCs) to induce primary T cell response against infection. Therefore, we hypothesized that blood DCs should augment NK cell function and reduce the risk of leukemia relapse after HCT. To test this hypothesis, we conducted laboratory and clinical studies in parallel. We found that although, phenotypically, NK cells could induce DC maturation and DCs could in turn increase activating marker expression on NK cells, paradoxically, both BDCA1+ myeloid DCs and BDCA4+ plasmacytoid DCs suppressed the function of NK cells. Patients who received an HLA-haploidentical graft containing a larger number of BDCA1+ DCs or BDCA4+ DCs had a higher risk of leukemia relapse and poorer survival. Further experiments indicated that the potent inhibition on NK cell cytokine production and cytotoxicity was mediated in part through the secretion of IL-10 by BDCA1+ DCs and IL-6 by BDCA4+ DCs. These results have significant implications for future HCT strategies. © 2011 American Society for Blood and Marrow Transplantation.-
dc.languageeng-
dc.relation.ispartofBiology of Blood and Marrow Transplantation-
dc.subjectCendritic cell-
dc.subjectPediatric leukemia-
dc.subjectHuman nK cell-
dc.subjectAlloegenic hematopoietic cell transplantation-
dc.titleBlood Dendritic Cells Suppress NK Cell Function and Increase the Risk of Leukemia Relapse after Hematopoietic Cell Transplantation-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.bbmt.2010.10.019-
dc.identifier.pmid20977942-
dc.identifier.pmcidPMC3047596-
dc.identifier.scopuseid_2-s2.0-79954606445-
dc.identifier.volume17-
dc.identifier.issue5-
dc.identifier.spage598-
dc.identifier.epage607-
dc.identifier.eissn1523-6536-
dc.identifier.isiWOS:000290061500002-
dc.identifier.issnl1083-8791-

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