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Article: Haploidentical stem cell transplantation augmented by CD45RA negative lymphocytes provides rapid engraftment and excellent tolerability

TitleHaploidentical stem cell transplantation augmented by CD45RA negative lymphocytes provides rapid engraftment and excellent tolerability
Authors
KeywordsNK cells BMT
Immunotherapy
Stem cell transplantation
Graft versus host disease
Issue Date2015
Citation
Pediatric Blood and Cancer, 2015, v. 62, n. 4, p. 666-673 How to Cite?
Abstract© 2015 Wiley Periodicals, Inc. Background: Haploidentical donors are being increasingly used for allogeneic hematopoietic cell transplantation (HCT). However, the requisite T-cell depletion results in a profound and often long-lasting immunocompromised state, and donor lymphocyte infusions bring a risk of graft-versus-host disease (GVHD). Naïve T-cells are believed to be among the most alloreactive T-cell subset and can be identified by CD45RA expression. Allogeneic HCT using CD45RA depletion has not been previously described for haploidentical donors. Procedure: Eight children with relapsed or refractory solid tumors were transplanted following myeloablative conditioning. Each patient received two cell products, one created by CD3 depletion and the other through CD45RA depletion. Results: Median CD34 recovery was 59.2% with CD45RA depletion, compared to 82.4% using CD3 depletion. Median CD3+ T-cell dose after CD45RA reduction was 99.2×106cells/kg, yet depletion of CD3+CD45RA+ cells exceeded 4.5 log. CD45RA depletion also resulted in substantial depletion of B-cells (median 2.45 log). All eight patients engrafted within 14 days and rapidly achieved 100% donor chimerism. No acute GVHD or secondary graft failure was observed. Conclusions: CD45RA depletion is a novel approach to haploidentical HCT that offers rapid engraftment with minimal risk of GVHD. Pediatr Blood Cancer 2015;62:666-673.
Persistent Identifierhttp://hdl.handle.net/10722/294475
ISSN
2020 Impact Factor: 3.167
2015 SCImago Journal Rankings: 1.505
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShook, David R.-
dc.contributor.authorTriplett, Brandon M.-
dc.contributor.authorEldridge, Paul W.-
dc.contributor.authorKang, Guolian-
dc.contributor.authorSrinivasan, Ashok-
dc.contributor.authorLeung, Wing-
dc.date.accessioned2020-12-03T08:22:49Z-
dc.date.available2020-12-03T08:22:49Z-
dc.date.issued2015-
dc.identifier.citationPediatric Blood and Cancer, 2015, v. 62, n. 4, p. 666-673-
dc.identifier.issn1545-5009-
dc.identifier.urihttp://hdl.handle.net/10722/294475-
dc.description.abstract© 2015 Wiley Periodicals, Inc. Background: Haploidentical donors are being increasingly used for allogeneic hematopoietic cell transplantation (HCT). However, the requisite T-cell depletion results in a profound and often long-lasting immunocompromised state, and donor lymphocyte infusions bring a risk of graft-versus-host disease (GVHD). Naïve T-cells are believed to be among the most alloreactive T-cell subset and can be identified by CD45RA expression. Allogeneic HCT using CD45RA depletion has not been previously described for haploidentical donors. Procedure: Eight children with relapsed or refractory solid tumors were transplanted following myeloablative conditioning. Each patient received two cell products, one created by CD3 depletion and the other through CD45RA depletion. Results: Median CD34 recovery was 59.2% with CD45RA depletion, compared to 82.4% using CD3 depletion. Median CD3+ T-cell dose after CD45RA reduction was 99.2×106cells/kg, yet depletion of CD3+CD45RA+ cells exceeded 4.5 log. CD45RA depletion also resulted in substantial depletion of B-cells (median 2.45 log). All eight patients engrafted within 14 days and rapidly achieved 100% donor chimerism. No acute GVHD or secondary graft failure was observed. Conclusions: CD45RA depletion is a novel approach to haploidentical HCT that offers rapid engraftment with minimal risk of GVHD. Pediatr Blood Cancer 2015;62:666-673.-
dc.languageeng-
dc.relation.ispartofPediatric Blood and Cancer-
dc.subjectNK cells BMT-
dc.subjectImmunotherapy-
dc.subjectStem cell transplantation-
dc.subjectGraft versus host disease-
dc.titleHaploidentical stem cell transplantation augmented by CD45RA negative lymphocytes provides rapid engraftment and excellent tolerability-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/pbc.25352-
dc.identifier.pmid25559618-
dc.identifier.scopuseid_2-s2.0-84923225278-
dc.identifier.volume62-
dc.identifier.issue4-
dc.identifier.spage666-
dc.identifier.epage673-
dc.identifier.eissn1545-5017-
dc.identifier.isiWOS:000349985300021-
dc.identifier.issnl1545-5009-

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