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Article: Impact of Adenoviral Stool Load on Adenoviremia in Pediatric Hematopoietic Stem Cell Transplant Recipients

TitleImpact of Adenoviral Stool Load on Adenoviremia in Pediatric Hematopoietic Stem Cell Transplant Recipients
Authors
Keywordsadenovirus
pediatric
transplant
stool
Issue Date2015
Citation
Pediatric Infectious Disease Journal, 2015, v. 34, n. 6, p. 562-565 How to Cite?
Abstract© 2015 Wolters Kluwer Health, Inc. All rights reserved. Background: Adenoviremia adversely affects prognosis in the post-hematopoietic stem cell transplant setting. Methods: We sought to determine retrospectively the cutoff load of adenovirus in the stool as a predictor of adenoviremia, in children who underwent an allogeneic hematopoietic stem cell transplant. The prevalence of sapovirus, norovirus and astrovirus in the stool was also studied. Results: The study cohort consisted of 117 patients, of which 71 (60%) had diarrhea. Adenovirus was detected in the stool in 39 of 71 (55%) patients. Age ≤10 years (P = 0.05; odds ratio: 2.57; 95% confidence interval: 0.98-6.75) and male sex (P = 0.04; odds ratio: 2.67; 95% confidence interval: 1.02-6.99) increased risk for detection of adenovirus in stool on univariate analysis. Coinfections with enteric pathogens were infrequent. Viral load >106 copies/g stool predicted adenoviremia with a sensitivity and specificity of 82%. Sapovirus, norovirus and astrovirus were detected in 3, 4 and 1 patient, respectively. Conclusions: Quantitative detection of adenovirus in stool may have implications for preemptive therapy. Testing for other enteric viruses may have implications for infection control.
Persistent Identifierhttp://hdl.handle.net/10722/294481
ISSN
2020 Impact Factor: 2.129
2015 SCImago Journal Rankings: 1.416
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSrinivasan, Ashok-
dc.contributor.authorKlepper, Corie-
dc.contributor.authorSunkara, Anusha-
dc.contributor.authorKang, Guolian-
dc.contributor.authorCarr, Jeanne-
dc.contributor.authorGu, Zhengming-
dc.contributor.authorLeung, Wing-
dc.contributor.authorHayden, Randall T.-
dc.date.accessioned2020-12-03T08:22:50Z-
dc.date.available2020-12-03T08:22:50Z-
dc.date.issued2015-
dc.identifier.citationPediatric Infectious Disease Journal, 2015, v. 34, n. 6, p. 562-565-
dc.identifier.issn0891-3668-
dc.identifier.urihttp://hdl.handle.net/10722/294481-
dc.description.abstract© 2015 Wolters Kluwer Health, Inc. All rights reserved. Background: Adenoviremia adversely affects prognosis in the post-hematopoietic stem cell transplant setting. Methods: We sought to determine retrospectively the cutoff load of adenovirus in the stool as a predictor of adenoviremia, in children who underwent an allogeneic hematopoietic stem cell transplant. The prevalence of sapovirus, norovirus and astrovirus in the stool was also studied. Results: The study cohort consisted of 117 patients, of which 71 (60%) had diarrhea. Adenovirus was detected in the stool in 39 of 71 (55%) patients. Age ≤10 years (P = 0.05; odds ratio: 2.57; 95% confidence interval: 0.98-6.75) and male sex (P = 0.04; odds ratio: 2.67; 95% confidence interval: 1.02-6.99) increased risk for detection of adenovirus in stool on univariate analysis. Coinfections with enteric pathogens were infrequent. Viral load >10<sup>6</sup> copies/g stool predicted adenoviremia with a sensitivity and specificity of 82%. Sapovirus, norovirus and astrovirus were detected in 3, 4 and 1 patient, respectively. Conclusions: Quantitative detection of adenovirus in stool may have implications for preemptive therapy. Testing for other enteric viruses may have implications for infection control.-
dc.languageeng-
dc.relation.ispartofPediatric Infectious Disease Journal-
dc.subjectadenovirus-
dc.subjectpediatric-
dc.subjecttransplant-
dc.subjectstool-
dc.titleImpact of Adenoviral Stool Load on Adenoviremia in Pediatric Hematopoietic Stem Cell Transplant Recipients-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1097/INF.0000000000000678-
dc.identifier.pmid25742243-
dc.identifier.pmcidPMC4517470-
dc.identifier.scopuseid_2-s2.0-84937701207-
dc.identifier.volume34-
dc.identifier.issue6-
dc.identifier.spage562-
dc.identifier.epage565-
dc.identifier.eissn1532-0987-
dc.identifier.isiWOS:000354722300005-
dc.identifier.issnl0891-3668-

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