File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effective donor lymphohematopoietic reconstitution after haploidentical CD34+ -selected hematopoietic stem cell transplantation in children with refractory severe aplastic anemia

TitleEffective donor lymphohematopoietic reconstitution after haploidentical CD34<sup>+</sup> -selected hematopoietic stem cell transplantation in children with refractory severe aplastic anemia
Authors
KeywordsHaploidentical
Aplastic anemia
Immune reconstitution
Issue Date2004
Citation
Bone Marrow Transplantation, 2004, v. 33, n. 4, p. 411-418 How to Cite?
AbstractPeritransplant toxicity and a delay in effective immune reconstitution have limited the utility of alternate donor transplantation for children with refractory severe aplastic anemia. We have assessed the effectiveness of infusing large numbers of highly purified haploidentical CD34+ cells after immunoablative conditioning in three patients who had failed intensive immunosuppression, lacked unrelated donors, and had active or recent serious infections. One patient rejected the first infusion, but engrafted after a second infusion from the same donor. This patient died 4 months after hematopoietic stem cell transplantation with no evidence of lymphoid reconstitution. Two patients experienced mixed chimerism requiring treatment with antibodies and/or donor lymphocyte infusion. Both currently survive more than 1 year after transplantation with normal blood counts, 100% donor engraftment, effective lymphoid reconstitution, and no chronic graft-versus-host disease. We observed functional thymopoiesis as measured by lymphocyte immunophenotyping, T cell receptor excision circles and T cell receptor Vβ spectratyping complexity analysis. Further study is required to validate the initial promise of these preliminary observations. © 2004 Nature Publishing Group All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/294487
ISSN
2020 Impact Factor: 5.483
2020 SCImago Journal Rankings: 1.609
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWoodard, Paul-
dc.contributor.authorCunningham, J. M.-
dc.contributor.authorBenaim, E.-
dc.contributor.authorChen, X.-
dc.contributor.authorHale, G.-
dc.contributor.authorHorwitz, E.-
dc.contributor.authorHouston, J.-
dc.contributor.authorKasow, K.-
dc.contributor.authorLeung, W.-
dc.contributor.authorWang, W.-
dc.contributor.authorYusuf, U.-
dc.contributor.authorHandgretinger, R.-
dc.date.accessioned2020-12-03T08:22:51Z-
dc.date.available2020-12-03T08:22:51Z-
dc.date.issued2004-
dc.identifier.citationBone Marrow Transplantation, 2004, v. 33, n. 4, p. 411-418-
dc.identifier.issn0268-3369-
dc.identifier.urihttp://hdl.handle.net/10722/294487-
dc.description.abstractPeritransplant toxicity and a delay in effective immune reconstitution have limited the utility of alternate donor transplantation for children with refractory severe aplastic anemia. We have assessed the effectiveness of infusing large numbers of highly purified haploidentical CD34+ cells after immunoablative conditioning in three patients who had failed intensive immunosuppression, lacked unrelated donors, and had active or recent serious infections. One patient rejected the first infusion, but engrafted after a second infusion from the same donor. This patient died 4 months after hematopoietic stem cell transplantation with no evidence of lymphoid reconstitution. Two patients experienced mixed chimerism requiring treatment with antibodies and/or donor lymphocyte infusion. Both currently survive more than 1 year after transplantation with normal blood counts, 100% donor engraftment, effective lymphoid reconstitution, and no chronic graft-versus-host disease. We observed functional thymopoiesis as measured by lymphocyte immunophenotyping, T cell receptor excision circles and T cell receptor Vβ spectratyping complexity analysis. Further study is required to validate the initial promise of these preliminary observations. © 2004 Nature Publishing Group All rights reserved.-
dc.languageeng-
dc.relation.ispartofBone Marrow Transplantation-
dc.subjectHaploidentical-
dc.subjectAplastic anemia-
dc.subjectImmune reconstitution-
dc.titleEffective donor lymphohematopoietic reconstitution after haploidentical CD34<sup>+</sup> -selected hematopoietic stem cell transplantation in children with refractory severe aplastic anemia-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/sj.bmt.1704358-
dc.identifier.pmid14676782-
dc.identifier.scopuseid_2-s2.0-12144286288-
dc.identifier.volume33-
dc.identifier.issue4-
dc.identifier.spage411-
dc.identifier.epage418-
dc.identifier.isiWOS:000188854200008-
dc.identifier.issnl0268-3369-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats