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Article: Definition of cure in childhood acute myeloid leukemia

TitleDefinition of cure in childhood acute myeloid leukemia
Authors
Keywordschildhood
treatment era
relapse
acute myeloid leukemia
Issue Date2014
Citation
Cancer, 2014, v. 120, n. 16, p. 2490-2496 How to Cite?
AbstractBACKGROUND A better understanding of when cure can be declared in childhood acute myeloid leukemia (AML) would reduce anxiety and improve quality of life of AML survivors. The authors determined the likelihood that patients with AML would maintain long-term remission after the completion of therapy. METHODS The cumulative risk of relapse, the time to relapse, event-free survival, and overall survival were analyzed for 604 patients with AML who were enrolled in 7 successive clinical trials divided into 3 treatment eras (1976-1991, 1991-1997, and 2002-2008). RESULTS The median time to relapse did not change over time (0.93 years vs 0.76 years vs 0.8 years, respectively, for each consecutive era; P = .22), but the risk of relapse decreased significantly (5-year cumulative incidence of relapse: 52.6% ± 3.1% vs 31.5% ± 3.9% vs 22% ± 3%, respectively, for each consecutive era; P < .001). Among patients who were in remission 4 years from diagnosis, the probabilities of relapse were 1.7%, 2.9%, and 0.9%, respectively, for each consecutive era. In the most recent era, all but 1 of 44 relapses occurred within 4 years of diagnosis. CONCLUSIONS Children with AML who receive treatment with contemporary therapy and remain in remission 4 years from diagnosis probably are cured. Although late relapses and late deaths from other causes are rare, long-term follow-up of survivors is necessary for the timely management of late adverse effects. © 2014 American Cancer Society.
Persistent Identifierhttp://hdl.handle.net/10722/294498
ISSN
2020 Impact Factor: 6.86
2015 SCImago Journal Rankings: 3.188
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRubnitz, Jeffrey E.-
dc.contributor.authorInaba, Hiroto-
dc.contributor.authorLeung, Wing H.-
dc.contributor.authorPounds, Stanley-
dc.contributor.authorCao, Xueyuan-
dc.contributor.authorCampana, Dario-
dc.contributor.authorRibeiro, Raul C.-
dc.contributor.authorPui, Ching Hon-
dc.date.accessioned2020-12-03T08:22:52Z-
dc.date.available2020-12-03T08:22:52Z-
dc.date.issued2014-
dc.identifier.citationCancer, 2014, v. 120, n. 16, p. 2490-2496-
dc.identifier.issn0008-543X-
dc.identifier.urihttp://hdl.handle.net/10722/294498-
dc.description.abstractBACKGROUND A better understanding of when cure can be declared in childhood acute myeloid leukemia (AML) would reduce anxiety and improve quality of life of AML survivors. The authors determined the likelihood that patients with AML would maintain long-term remission after the completion of therapy. METHODS The cumulative risk of relapse, the time to relapse, event-free survival, and overall survival were analyzed for 604 patients with AML who were enrolled in 7 successive clinical trials divided into 3 treatment eras (1976-1991, 1991-1997, and 2002-2008). RESULTS The median time to relapse did not change over time (0.93 years vs 0.76 years vs 0.8 years, respectively, for each consecutive era; P = .22), but the risk of relapse decreased significantly (5-year cumulative incidence of relapse: 52.6% ± 3.1% vs 31.5% ± 3.9% vs 22% ± 3%, respectively, for each consecutive era; P < .001). Among patients who were in remission 4 years from diagnosis, the probabilities of relapse were 1.7%, 2.9%, and 0.9%, respectively, for each consecutive era. In the most recent era, all but 1 of 44 relapses occurred within 4 years of diagnosis. CONCLUSIONS Children with AML who receive treatment with contemporary therapy and remain in remission 4 years from diagnosis probably are cured. Although late relapses and late deaths from other causes are rare, long-term follow-up of survivors is necessary for the timely management of late adverse effects. © 2014 American Cancer Society.-
dc.languageeng-
dc.relation.ispartofCancer-
dc.subjectchildhood-
dc.subjecttreatment era-
dc.subjectrelapse-
dc.subjectacute myeloid leukemia-
dc.titleDefinition of cure in childhood acute myeloid leukemia-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/cncr.28742-
dc.identifier.pmid24798038-
dc.identifier.pmcidPMC4282842-
dc.identifier.scopuseid_2-s2.0-84905560879-
dc.identifier.volume120-
dc.identifier.issue16-
dc.identifier.spage2490-
dc.identifier.epage2496-
dc.identifier.eissn1097-0142-
dc.identifier.isiWOS:000340464100016-
dc.identifier.issnl0008-543X-

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