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Article: DNA Nanotechnology for Modulating the Growth and Development of Neurons
Title | DNA Nanotechnology for Modulating the Growth and Development of Neurons |
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Authors | |
Keywords | Neocortical neurons Trispecific activation/deactivation DNA nanomechanical device Somal terminal translocation Migration of the neuronal endings Neuronal surface receptors |
Issue Date | 2021 |
Citation | CCS Chemistry, 2021, v. 3 n. 9, p. 2381-2393 How to Cite? |
Abstract | Late prenatal growth, early postnatal growth, and layering of the neocortical neurons (NC-Ns) play determining roles in the development of the cerebral cortex (CC). Here, we systematically explore the interactive role of neuronal surface receptors (NSRs) on cytoskeleton activation (CA) and the piconewton (pN) force generation (P-FG) and their influence on the proper development, growth, and functioning of neurons using a designed DNA nanomechanical device (DNA-NMD). This DNA-NMD, functioning as a molecular tension probe (MTP), can be used to selectively bind the different NSRs (β-NGFR, Reelin, and Integrin) to mono-, bi-, and trispecifically activate the receptors on the NC-Ns surface for imaging and calculating the P-FG involved in various processes. Measurements in vivo on the brain of newly born Institute of Cancer Research mice (early postnatal) or in vitro after extracting neurons from the fetal brain of pregnant Institute of Cancer Research mice (late prenatal) reveal that there are augmented interactive roles of the β-NGFR with Integrin and Reelin receptors (RR) on the CA and P-FG, resulting in enhanced directional migration of the neuronal endings (M-NEs), layering, and the somal terminal translocation (S-TT) followed by early postnatal growth. |
Persistent Identifier | http://hdl.handle.net/10722/294786 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 2.726 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Baig, Mirza Muhammad Faran Ashraf | - |
dc.contributor.author | Wen, Chunxia | - |
dc.contributor.author | Li, Jian | - |
dc.contributor.author | Qin, Xiang | - |
dc.contributor.author | Ahmed, Saud Asif | - |
dc.contributor.author | Xia, Xing-Hua | - |
dc.date.accessioned | 2020-12-10T09:47:53Z | - |
dc.date.available | 2020-12-10T09:47:53Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | CCS Chemistry, 2021, v. 3 n. 9, p. 2381-2393 | - |
dc.identifier.issn | 2096-5745 | - |
dc.identifier.uri | http://hdl.handle.net/10722/294786 | - |
dc.description.abstract | Late prenatal growth, early postnatal growth, and layering of the neocortical neurons (NC-Ns) play determining roles in the development of the cerebral cortex (CC). Here, we systematically explore the interactive role of neuronal surface receptors (NSRs) on cytoskeleton activation (CA) and the piconewton (pN) force generation (P-FG) and their influence on the proper development, growth, and functioning of neurons using a designed DNA nanomechanical device (DNA-NMD). This DNA-NMD, functioning as a molecular tension probe (MTP), can be used to selectively bind the different NSRs (β-NGFR, Reelin, and Integrin) to mono-, bi-, and trispecifically activate the receptors on the NC-Ns surface for imaging and calculating the P-FG involved in various processes. Measurements in vivo on the brain of newly born Institute of Cancer Research mice (early postnatal) or in vitro after extracting neurons from the fetal brain of pregnant Institute of Cancer Research mice (late prenatal) reveal that there are augmented interactive roles of the β-NGFR with Integrin and Reelin receptors (RR) on the CA and P-FG, resulting in enhanced directional migration of the neuronal endings (M-NEs), layering, and the somal terminal translocation (S-TT) followed by early postnatal growth. | - |
dc.language | eng | - |
dc.relation.ispartof | CCS Chemistry | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Neocortical neurons | - |
dc.subject | Trispecific activation/deactivation | - |
dc.subject | DNA nanomechanical device | - |
dc.subject | Somal terminal translocation | - |
dc.subject | Migration of the neuronal endings | - |
dc.subject | Neuronal surface receptors | - |
dc.title | DNA Nanotechnology for Modulating the Growth and Development of Neurons | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.31635/ccschem.020.202000456 | - |
dc.identifier.scopus | eid_2-s2.0-85115923757 | - |
dc.identifier.hkuros | 320904 | - |
dc.identifier.volume | 3 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 2381 | - |
dc.identifier.epage | 2393 | - |
dc.identifier.isi | WOS:000794230300006 | - |
dc.identifier.issnl | 2096-5745 | - |