File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy

TitleAnalysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy
Authors
KeywordsALS
Epilepsy
Genetic correlation
Issue Date2020
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/neuaging
Citation
Neurobiology of Aging, 2020, v. 92, p. 153.e1-153.e5 How to Cite?
AbstractBecause hyper-excitability has been shown to be a shared pathophysiological mechanism, we used the latest and largest genome-wide studies in amyotrophic lateral sclerosis (n = 36,052) and epilepsy (n = 38,349) to determine genetic overlap between these conditions. First, we showed no significant genetic correlation, also when binned on minor allele frequency. Second, we confirmed the absence of polygenic overlap using genomic risk score analysis. Finally, we did not identify pleiotropic variants in meta-analyses of the 2 diseases. Our findings indicate that amyotrophic lateral sclerosis and epilepsy do not share common genetic risk, showing that hyper-excitability in both disorders has distinct origins.
DescriptionHybrid open access
Persistent Identifierhttp://hdl.handle.net/10722/295479
ISSN
2023 Impact Factor: 3.7
2023 SCImago Journal Rankings: 1.488
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorSchijven, D-
dc.contributor.authorStevelink, R-
dc.contributor.authorMcCormack, M-
dc.contributor.authorvan Rheenen, W-
dc.contributor.authorLuykx, JJ-
dc.contributor.authorKoeleman, BPC-
dc.contributor.authorVeldink, JH-
dc.contributor.authorProject MinE ALS GWAS Consortium,-
dc.contributor.authorInternational League Against Epilepsy Consortium on Complex Epilepsies,-
dc.contributor.authorYang, W-
dc.date.accessioned2021-01-25T11:15:29Z-
dc.date.available2021-01-25T11:15:29Z-
dc.date.issued2020-
dc.identifier.citationNeurobiology of Aging, 2020, v. 92, p. 153.e1-153.e5-
dc.identifier.issn0197-4580-
dc.identifier.urihttp://hdl.handle.net/10722/295479-
dc.descriptionHybrid open access-
dc.description.abstractBecause hyper-excitability has been shown to be a shared pathophysiological mechanism, we used the latest and largest genome-wide studies in amyotrophic lateral sclerosis (n = 36,052) and epilepsy (n = 38,349) to determine genetic overlap between these conditions. First, we showed no significant genetic correlation, also when binned on minor allele frequency. Second, we confirmed the absence of polygenic overlap using genomic risk score analysis. Finally, we did not identify pleiotropic variants in meta-analyses of the 2 diseases. Our findings indicate that amyotrophic lateral sclerosis and epilepsy do not share common genetic risk, showing that hyper-excitability in both disorders has distinct origins.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/neuaging-
dc.relation.ispartofNeurobiology of Aging-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectALS-
dc.subjectEpilepsy-
dc.subjectGenetic correlation-
dc.titleAnalysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy-
dc.typeArticle-
dc.identifier.emailYang, W: yangwl@hku.hk-
dc.identifier.authorityYang, W=rp00524-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.neurobiolaging.2020.04.011-
dc.identifier.pmid2409253-
dc.identifier.pmcidPMC7818383-
dc.identifier.scopuseid_2-s2.0-85084453564-
dc.identifier.hkuros320966-
dc.identifier.volume92-
dc.identifier.spage153.e1-
dc.identifier.epage153.e5-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats