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Article: APOE-ε4 carrier status and gut microbiota dysbiosis in patients with Alzheimer disease

TitleAPOE-ε4 carrier status and gut microbiota dysbiosis in patients with Alzheimer disease
Authors
KeywordsAlzheimer disease
apolipoprotein E
dysbiosis
genetic variants
gut microbiome
Issue Date2021
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/neuroscience
Citation
Frontiers in Neuroscience, 2021, v. 15, p. article no. 619051 How to Cite?
AbstractBackground: Alternations in gut microbiota and a number of genes have been implicated as risk factors for the development of Alzheimer disease (AD). However, the interactions between the altered bacteria and risk genetic variants remain unclear. Objective: We aimed to explore associations of the risk genetic variants with altered gut bacteria in the onset of AD. Methods: We collected baseline data and stool and blood samples from 30 AD patients and 47 healthy controls in a case-control study. The rs42358/rs4512 (ApoE), rs3851179 (PICALM), rs744373 (BIN1), rs9331888 (CLU), rs670139 (MS4A4E), rs3764650 (ABCA7), rs3865444 (CD33), rs9349407 (CD2AP), rs11771145 (EPHA1), and rs3818361/rs6656401 (CR1) were sequenced, and microbiota composition was characterized using 16S rRNA gene sequencing. The associations of the altered gut bacteria with the risk genetics were analyzed. Results: Apolipoprotein ε4 allele and rs744373 were risk loci for the AD among 12 genetic variants. Phylum Proteobacteria; orders Enterobacteriales, Deltaproteobacteria, and Desulfovibrionales; families Enterobacteriaceae and Desulfovibrionaceae; and genera Escherichia–Shigella, Ruminococcaceae_UCG_002, Shuttleworthia, Anaerofustis, Morganelia, Finegoldia, and Anaerotruncus were increased in AD subjects, whereas family Enterococcaceae and genera Megamonas, Enterococcus, and Anaerostipes were more abundant in controls (P < 0.05). Among the altered microbiota, APOE ε4 allele was positively associated with pathogens: Proteobacteria. Conclusion: The interaction of APOE ε4 gene and the AD-promoting pathogens might be an important factor requiring for the promotion of AD. Targeting to microbiota might be an effective therapeutic strategy for AD susceptible to APOE ε4 allele. This needs further investigation.
Persistent Identifierhttp://hdl.handle.net/10722/295529
ISSN
2023 Impact Factor: 3.2
2023 SCImago Journal Rankings: 1.063
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHou, M-
dc.contributor.authorLian, G-
dc.contributor.authorRan, M-
dc.contributor.authorLuo, W-
dc.contributor.authorWang, H-
dc.date.accessioned2021-01-25T11:16:10Z-
dc.date.available2021-01-25T11:16:10Z-
dc.date.issued2021-
dc.identifier.citationFrontiers in Neuroscience, 2021, v. 15, p. article no. 619051-
dc.identifier.issn1662-453X-
dc.identifier.urihttp://hdl.handle.net/10722/295529-
dc.description.abstractBackground: Alternations in gut microbiota and a number of genes have been implicated as risk factors for the development of Alzheimer disease (AD). However, the interactions between the altered bacteria and risk genetic variants remain unclear. Objective: We aimed to explore associations of the risk genetic variants with altered gut bacteria in the onset of AD. Methods: We collected baseline data and stool and blood samples from 30 AD patients and 47 healthy controls in a case-control study. The rs42358/rs4512 (ApoE), rs3851179 (PICALM), rs744373 (BIN1), rs9331888 (CLU), rs670139 (MS4A4E), rs3764650 (ABCA7), rs3865444 (CD33), rs9349407 (CD2AP), rs11771145 (EPHA1), and rs3818361/rs6656401 (CR1) were sequenced, and microbiota composition was characterized using 16S rRNA gene sequencing. The associations of the altered gut bacteria with the risk genetics were analyzed. Results: Apolipoprotein ε4 allele and rs744373 were risk loci for the AD among 12 genetic variants. Phylum Proteobacteria; orders Enterobacteriales, Deltaproteobacteria, and Desulfovibrionales; families Enterobacteriaceae and Desulfovibrionaceae; and genera Escherichia–Shigella, Ruminococcaceae_UCG_002, Shuttleworthia, Anaerofustis, Morganelia, Finegoldia, and Anaerotruncus were increased in AD subjects, whereas family Enterococcaceae and genera Megamonas, Enterococcus, and Anaerostipes were more abundant in controls (P < 0.05). Among the altered microbiota, APOE ε4 allele was positively associated with pathogens: Proteobacteria. Conclusion: The interaction of APOE ε4 gene and the AD-promoting pathogens might be an important factor requiring for the promotion of AD. Targeting to microbiota might be an effective therapeutic strategy for AD susceptible to APOE ε4 allele. This needs further investigation.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/neuroscience-
dc.relation.ispartofFrontiers in Neuroscience-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAlzheimer disease-
dc.subjectapolipoprotein E-
dc.subjectdysbiosis-
dc.subjectgenetic variants-
dc.subjectgut microbiome-
dc.titleAPOE-ε4 carrier status and gut microbiota dysbiosis in patients with Alzheimer disease-
dc.typeArticle-
dc.identifier.emailRan, M: msran@hku.hk-
dc.identifier.authorityRan, M=rp01788-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fnins.2021.619051-
dc.identifier.pmid33732104-
dc.identifier.pmcidPMC7959830-
dc.identifier.scopuseid_2-s2.0-85102368656-
dc.identifier.hkuros320993-
dc.identifier.volume15-
dc.identifier.spagearticle no. 619051-
dc.identifier.epagearticle no. 619051-
dc.identifier.isiWOS:000626896900001-
dc.publisher.placeSwitzerland-

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