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Conference Paper: Molecular medicine in the emergency room: plasma DNA in trauma
Title | Molecular medicine in the emergency room: plasma DNA in trauma |
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Authors | |
Issue Date | 2001 |
Publisher | American Association for Clinical Chemistry. |
Citation | The Second International Symposium on Circulating Nucleic Acids in Plasma and Serum (CNAPS-2) and the 6th Annual Scientific Symposium of the Hong Kong Cancer Institute, Hong Kong, 20-21 February 2001. In Clinical Chemistry, 2001, v. 47, n. 2, p. 363 How to Cite? |
Abstract | Circulating cell-free plasma DNA is useful for the clinical diagnosis and prognosis of cancer patients, pregnant women and organ transplantation recipients, and may be liberated into plasma either as a result of apoptosis or direct injury. As bodily trauma involves considerable tissue damage, DNA may be liberated from tissues within minutes to hours after such injury. There is a positive correlation between early plasma DNA levels and injury severity, and levels are highest in those patients who develop the acute respiratory distress syndrome, multiple organ dysfunction syndrome and those who eventually die. Plasma DNA can be measured within minutes to hours after injury using a real-time, quantitative, polymerase chain reaction assay. Using DNA and other markers entered into a Classification and Regression Tree, it is possible to derive a prediction rule for post-traumatic complications with high sensitivity, specificity and positive predictive values. These guidelines require prospective validation before they find a place as research tools. |
Persistent Identifier | http://hdl.handle.net/10722/295683 |
ISSN | 2023 Impact Factor: 7.1 2023 SCImago Journal Rankings: 1.460 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Rainer, TH | - |
dc.date.accessioned | 2021-02-05T02:14:02Z | - |
dc.date.available | 2021-02-05T02:14:02Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | The Second International Symposium on Circulating Nucleic Acids in Plasma and Serum (CNAPS-2) and the 6th Annual Scientific Symposium of the Hong Kong Cancer Institute, Hong Kong, 20-21 February 2001. In Clinical Chemistry, 2001, v. 47, n. 2, p. 363 | - |
dc.identifier.issn | 0009-9147 | - |
dc.identifier.uri | http://hdl.handle.net/10722/295683 | - |
dc.description.abstract | Circulating cell-free plasma DNA is useful for the clinical diagnosis and prognosis of cancer patients, pregnant women and organ transplantation recipients, and may be liberated into plasma either as a result of apoptosis or direct injury. As bodily trauma involves considerable tissue damage, DNA may be liberated from tissues within minutes to hours after such injury. There is a positive correlation between early plasma DNA levels and injury severity, and levels are highest in those patients who develop the acute respiratory distress syndrome, multiple organ dysfunction syndrome and those who eventually die. Plasma DNA can be measured within minutes to hours after injury using a real-time, quantitative, polymerase chain reaction assay. Using DNA and other markers entered into a Classification and Regression Tree, it is possible to derive a prediction rule for post-traumatic complications with high sensitivity, specificity and positive predictive values. These guidelines require prospective validation before they find a place as research tools. | - |
dc.language | eng | - |
dc.publisher | American Association for Clinical Chemistry. | - |
dc.relation.ispartof | Clinical Chemistry | - |
dc.title | Molecular medicine in the emergency room: plasma DNA in trauma | - |
dc.type | Conference_Paper | - |
dc.description.nature | abstract | - |
dc.identifier.volume | 47 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 363 | - |
dc.identifier.epage | 363 | - |
dc.identifier.isi | WOS:000166805700045 | - |
dc.publisher.place | Hong Kong | - |
dc.identifier.partofdoi | 10.1093/clinchem/47.2.361 | - |
dc.identifier.issnl | 0009-9147 | - |