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Article: Is exercise a senolytic medicine? A systematic review

TitleIs exercise a senolytic medicine? A systematic review
Authors
Keywordscellular senescence
exercise
senescent cells
senolytic medicine
senolytics
Issue Date2021
PublisherWiley Open Access. The Journal's web site is located at https://onlinelibrary.wiley.com/journal/14749726
Citation
Aging Cell, 2021, v. 20 n. 1, p. article no. e13294 How to Cite?
AbstractCellular senescence, a state of irreversible growth arrest triggered by various stressors, engages in a category of pathological processes, whereby senescent cells accumulate in mitotic tissues. Senolytics as novel medicine against aging and various diseases through the elimination of senescent cells has emerged rapidly in recent years. Exercise is a potent anti-aging and anti-chronic disease medicine, which has shown the capacity to lower the markers of cellular senescence over the past decade. However, whether exercise is a senolytic medicine for aging and various diseases remains unclear. Here, we have conducted a systematic review of the published literature studying the senolytic effects of exercise or physical activity on senescent cells under various states in both human and animal models. Exercise can reduce the markers of senescent cells in healthy humans, while it lowered the markers of senescent cells in obese but not healthy animals. The discrepancy between human and animal studies may be due to the relatively small volume of research and the variations in markers of senescent cells, types of cells/tissues, and health conditions. These findings suggest that exercise has senolytic properties under certain conditions, which warrant further investigations.
Persistent Identifierhttp://hdl.handle.net/10722/295836
ISSN
2023 Impact Factor: 8.0
2023 SCImago Journal Rankings: 2.904
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, XK-
dc.contributor.authorYi, ZN-
dc.contributor.authorWong, GTC-
dc.contributor.authorHasan, KM-
dc.contributor.authorKwan, JSK-
dc.contributor.authorMa, ACH-
dc.contributor.authorChang, RCC-
dc.date.accessioned2021-02-08T08:14:42Z-
dc.date.available2021-02-08T08:14:42Z-
dc.date.issued2021-
dc.identifier.citationAging Cell, 2021, v. 20 n. 1, p. article no. e13294-
dc.identifier.issn1474-9718-
dc.identifier.urihttp://hdl.handle.net/10722/295836-
dc.description.abstractCellular senescence, a state of irreversible growth arrest triggered by various stressors, engages in a category of pathological processes, whereby senescent cells accumulate in mitotic tissues. Senolytics as novel medicine against aging and various diseases through the elimination of senescent cells has emerged rapidly in recent years. Exercise is a potent anti-aging and anti-chronic disease medicine, which has shown the capacity to lower the markers of cellular senescence over the past decade. However, whether exercise is a senolytic medicine for aging and various diseases remains unclear. Here, we have conducted a systematic review of the published literature studying the senolytic effects of exercise or physical activity on senescent cells under various states in both human and animal models. Exercise can reduce the markers of senescent cells in healthy humans, while it lowered the markers of senescent cells in obese but not healthy animals. The discrepancy between human and animal studies may be due to the relatively small volume of research and the variations in markers of senescent cells, types of cells/tissues, and health conditions. These findings suggest that exercise has senolytic properties under certain conditions, which warrant further investigations.-
dc.languageeng-
dc.publisherWiley Open Access. The Journal's web site is located at https://onlinelibrary.wiley.com/journal/14749726-
dc.relation.ispartofAging Cell-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectcellular senescence-
dc.subjectexercise-
dc.subjectsenescent cells-
dc.subjectsenolytic medicine-
dc.subjectsenolytics-
dc.titleIs exercise a senolytic medicine? A systematic review-
dc.typeArticle-
dc.identifier.emailChen, XK: kxkchen@HKUCC-COM.hku.hk-
dc.identifier.emailWong, GTC: gordon@hku.hk-
dc.identifier.emailChang, RCC: rccchang@hku.hk-
dc.identifier.authorityWong, GTC=rp00523-
dc.identifier.authorityChang, RCC=rp00470-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1111/acel.13294-
dc.identifier.pmid33378138-
dc.identifier.pmcidPMC7811843-
dc.identifier.scopuseid_2-s2.0-85098275749-
dc.identifier.hkuros321216-
dc.identifier.volume20-
dc.identifier.issue1-
dc.identifier.spagearticle no. e13294-
dc.identifier.epagearticle no. e13294-
dc.identifier.isiWOS:000603448300001-
dc.publisher.placeUnited Kingdom-

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