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- Publisher Website: 10.1089/ars.2019.7952
- Scopus: eid_2-s2.0-85087011530
- PMID: 32030995
- WOS: WOS:000525303500001
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Article: Reactive Oxygen Species and Their Impact in Neurodegenerative Diseases: Literature Landscape Analysis
Title | Reactive Oxygen Species and Their Impact in Neurodegenerative Diseases: Literature Landscape Analysis |
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Authors | |
Keywords | Alzheimer's disease bibliometric neurodegeneration oxidative stress Parkinson's disease |
Issue Date | 2021 |
Publisher | Mary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/ars |
Citation | Antioxidants & Redox Signaling, 2021, v. 34 n. 5, p. 402-420 How to Cite? |
Abstract | Significance: The excessive production of reactive oxygen species (ROS) has been linked to neurodegenerative diseases (NDs), and, therefore, many scientific works were published on the impact of ROS on the development of prevalent NDs, such as Alzheimer's disease (AD) and Parkinson's disease (PD). Since quantitative and qualitative bibliometric analyses in this research area have not yet been done, the aim of this work is to explore the scientific literature implying ROS in NDs and to identify the major contributors, mainstream research themes, and topics on the rise.
Recent Advances: Overall, 22,885 publications were identified and analyzed within the Web of Science (WoS) Core Collection electronic database (Clarivate Analytics, Philadelphia, PA). Most of the manuscripts were published in the 21st century. The publications were mainly related to the WoS categories Neurosciences and Biochemistry molecular biology. The United States is the major contributor, harboring the most productive authors and institutions. China, South Korea, and India have emerged as upcoming major contributors in the 2010s. Two most productive journals were Journal of Neurochemistry and Free Radical Biology and Medicine.
Critical Issues: AD, PD, and amyotrophic lateral sclerosis were much more investigated than multiple sclerosis and Huntington's disease. Vitamin E and curcumin were frequently mentioned as potential antioxidant therapeutics, but their efficacy in treating NDs requires more clinical studies, since the existing evidence was mainly from in vitro experiments and in vivo animal studies.
Future Directions: Mitochondrial dysfunction, autophagy, and nuclear factor erythroid 2-related factor 2 were among the author keywords with rising prevalence. Further research in these directions should advance our understanding of the mechanism and treatment of NDs. Antioxid. Redox Signal. 34, 402–420. |
Persistent Identifier | http://hdl.handle.net/10722/295847 |
ISSN | 2023 Impact Factor: 5.9 2023 SCImago Journal Rankings: 1.708 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yeung, AWK | - |
dc.contributor.author | Tzvetkov, NT | - |
dc.contributor.author | Georgieva, MG | - |
dc.contributor.author | Ognyanov, IV | - |
dc.contributor.author | Kordos, K | - |
dc.contributor.author | Jóźwik, A | - |
dc.contributor.author | Kühl, T | - |
dc.contributor.author | Perry, G | - |
dc.contributor.author | Petralia, MC | - |
dc.contributor.author | Mazzon, E | - |
dc.contributor.author | Atanasov, AG | - |
dc.date.accessioned | 2021-02-08T08:14:52Z | - |
dc.date.available | 2021-02-08T08:14:52Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Antioxidants & Redox Signaling, 2021, v. 34 n. 5, p. 402-420 | - |
dc.identifier.issn | 1523-0864 | - |
dc.identifier.uri | http://hdl.handle.net/10722/295847 | - |
dc.description.abstract | Significance: The excessive production of reactive oxygen species (ROS) has been linked to neurodegenerative diseases (NDs), and, therefore, many scientific works were published on the impact of ROS on the development of prevalent NDs, such as Alzheimer's disease (AD) and Parkinson's disease (PD). Since quantitative and qualitative bibliometric analyses in this research area have not yet been done, the aim of this work is to explore the scientific literature implying ROS in NDs and to identify the major contributors, mainstream research themes, and topics on the rise. Recent Advances: Overall, 22,885 publications were identified and analyzed within the Web of Science (WoS) Core Collection electronic database (Clarivate Analytics, Philadelphia, PA). Most of the manuscripts were published in the 21st century. The publications were mainly related to the WoS categories Neurosciences and Biochemistry molecular biology. The United States is the major contributor, harboring the most productive authors and institutions. China, South Korea, and India have emerged as upcoming major contributors in the 2010s. Two most productive journals were Journal of Neurochemistry and Free Radical Biology and Medicine. Critical Issues: AD, PD, and amyotrophic lateral sclerosis were much more investigated than multiple sclerosis and Huntington's disease. Vitamin E and curcumin were frequently mentioned as potential antioxidant therapeutics, but their efficacy in treating NDs requires more clinical studies, since the existing evidence was mainly from in vitro experiments and in vivo animal studies. Future Directions: Mitochondrial dysfunction, autophagy, and nuclear factor erythroid 2-related factor 2 were among the author keywords with rising prevalence. Further research in these directions should advance our understanding of the mechanism and treatment of NDs. Antioxid. Redox Signal. 34, 402–420. | - |
dc.language | eng | - |
dc.publisher | Mary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/ars | - |
dc.relation.ispartof | Antioxidants & Redox Signaling | - |
dc.rights | Antioxidants & Redox Signaling. Copyright © Mary Ann Liebert, Inc Publishers. | - |
dc.rights | Final publication is available from Mary Ann Liebert, Inc., publishers http://dx.doi.org/[insert DOI] | - |
dc.subject | Alzheimer's disease | - |
dc.subject | bibliometric | - |
dc.subject | neurodegeneration | - |
dc.subject | oxidative stress | - |
dc.subject | Parkinson's disease | - |
dc.title | Reactive Oxygen Species and Their Impact in Neurodegenerative Diseases: Literature Landscape Analysis | - |
dc.type | Article | - |
dc.identifier.email | Yeung, AWK: ndyeung@hku.hk | - |
dc.identifier.authority | Yeung, AWK=rp02143 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1089/ars.2019.7952 | - |
dc.identifier.pmid | 32030995 | - |
dc.identifier.scopus | eid_2-s2.0-85087011530 | - |
dc.identifier.hkuros | 321197 | - |
dc.identifier.volume | 34 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 402 | - |
dc.identifier.epage | 420 | - |
dc.identifier.isi | WOS:000525303500001 | - |
dc.publisher.place | United States | - |