Coat's Disease

Abstract

Coats’ disease is an idiopathic condition characterized by peripheral retinal telangiectasia with intraretinal and subretinal exudation. Isolated Coats’ disease is non-hereditary and the majority of cases are unilateral and affect young males, although bilateral and adult-onset cases do occur. Young children tend to present with leukocoria or strabismus, while older children and adults usually present with subjective vision loss or as an incidental finding. The clinical severity at presentation can range widely from retinal telangiectasia only to total retinal detachment with secondary ocular complications. Treatment is indicated in most cases and is effective at achieving good structural outcomes. However, the long-term visual prognosis remains poor, especially in advanced cases.