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Conference Paper: Test for Imprinting Effects on the X-Chromosome
Title | Test for Imprinting Effects on the X-Chromosome |
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Authors | |
Keywords | Imprinting effects X chromosome qualitative traits nuclear family |
Issue Date | 2018 |
Publisher | Institute of Statistical Science, Academia Sinica. |
Citation | 2018 Statistics Week Taiwan; Statistics for the Next Decade, Taipei, Taiwan, 5-9 November 2018 How to Cite? |
Abstract | Genomic imprinting is an epigenetic phenomenon that the expression of an allele copy depends on its parental origin. This mechanism has been found to play an important role in many diseases. Methods for detecting imprinting effects have been developed primarily for autosomal markers. However, no method is available in the literature to test for imprinting effects on the X chromosome. Therefore, it is necessary to suggest methods for detecting such imprinting effects. In this talk, the parental-asymmetry test on X the chromosome (XPAT) is first developed to test for imprinting for qualitative traits in the presence of association, based on family trios each with both parents and their affected daughter. Then, we propose 1-XPAT to tackle parent-daughter pairs, each with one parent and his/her affected daughter.
By simultaneously considering family trios and parent-daughter pairs, CXPAT is constructed to test for imprinting. Further, we extend the proposed methods to accommodate complete (with both parents) and incomplete (with one parent) nuclear families having multiple daughters of which at least one is affected. Simulations are conducted to assess the performance of the proposed methods under different settings. Simulation results demonstrate that the proposed methods control the size well, irrespective of the inbreeding coefficient in females being zero or nonzero. By incorporating incomplete nuclear families, C-XPAT is more powerful than XPAT using only complete nuclear families. For practical use, these proposed methods are applied to analyze the rheumatoid arthritis data. |
Description | The 2018 Statistics Week Taiwan is a joint conference of the Academia Sinica Frontiers of Sciences and Humanities Seminar Series – Statistics (Taipei, 5th Nov), ISI Young Statisticians Regional Workshop (Taipei, 6th Nov), NCKU-ISI Statistics Workshop and Forum (Tainan, 7th – 8th Nov), and CSA-NCU-ISI International Sessions (Taoyuan, 9th Nov) Workshop of ISI EC and Associations |
Persistent Identifier | http://hdl.handle.net/10722/297114 |
DC Field | Value | Language |
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dc.contributor.author | Fung, TWK | - |
dc.date.accessioned | 2021-03-05T06:27:38Z | - |
dc.date.available | 2021-03-05T06:27:38Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | 2018 Statistics Week Taiwan; Statistics for the Next Decade, Taipei, Taiwan, 5-9 November 2018 | - |
dc.identifier.uri | http://hdl.handle.net/10722/297114 | - |
dc.description | The 2018 Statistics Week Taiwan is a joint conference of the Academia Sinica Frontiers of Sciences and Humanities Seminar Series – Statistics (Taipei, 5th Nov), ISI Young Statisticians Regional Workshop (Taipei, 6th Nov), NCKU-ISI Statistics Workshop and Forum (Tainan, 7th – 8th Nov), and CSA-NCU-ISI International Sessions (Taoyuan, 9th Nov) | - |
dc.description | Workshop of ISI EC and Associations | - |
dc.description.abstract | Genomic imprinting is an epigenetic phenomenon that the expression of an allele copy depends on its parental origin. This mechanism has been found to play an important role in many diseases. Methods for detecting imprinting effects have been developed primarily for autosomal markers. However, no method is available in the literature to test for imprinting effects on the X chromosome. Therefore, it is necessary to suggest methods for detecting such imprinting effects. In this talk, the parental-asymmetry test on X the chromosome (XPAT) is first developed to test for imprinting for qualitative traits in the presence of association, based on family trios each with both parents and their affected daughter. Then, we propose 1-XPAT to tackle parent-daughter pairs, each with one parent and his/her affected daughter. By simultaneously considering family trios and parent-daughter pairs, CXPAT is constructed to test for imprinting. Further, we extend the proposed methods to accommodate complete (with both parents) and incomplete (with one parent) nuclear families having multiple daughters of which at least one is affected. Simulations are conducted to assess the performance of the proposed methods under different settings. Simulation results demonstrate that the proposed methods control the size well, irrespective of the inbreeding coefficient in females being zero or nonzero. By incorporating incomplete nuclear families, C-XPAT is more powerful than XPAT using only complete nuclear families. For practical use, these proposed methods are applied to analyze the rheumatoid arthritis data. | - |
dc.language | eng | - |
dc.publisher | Institute of Statistical Science, Academia Sinica. | - |
dc.relation.ispartof | 2018 Statistics Week Taiwan | - |
dc.subject | Imprinting effects | - |
dc.subject | X chromosome | - |
dc.subject | qualitative traits | - |
dc.subject | nuclear family | - |
dc.title | Test for Imprinting Effects on the X-Chromosome | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Fung, TWK: wingfung@hkucc.hku.hk | - |
dc.identifier.authority | Fung, TWK=rp00696 | - |
dc.identifier.hkuros | 300049 | - |
dc.publisher.place | Taiwan | - |