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Article: A Novel Small Molecule, 1,3-di-m-tolyl-urea, Inhibits and Disrupts Multispecies Oral Biofilms

TitleA Novel Small Molecule, 1,3-di-m-tolyl-urea, Inhibits and Disrupts Multispecies Oral Biofilms
Authors
KeywordsDMTU
multispecies biofilms
Porphyromonas gingivalis
quorum sensing
Issue Date2020
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/microorganisms
Citation
Microorganisms, 2020, v. 8 n. 9, p. article no. 1261 How to Cite?
AbstractAn imbalance of homeostasis between the microbial communities and the host system leads to dysbiosis in oral micro flora. DMTU (1,3-di-m-tolyl-urea) is a biocompatible compound that was shown to inhibitStreptococcus mutansbiofilm by inhibiting its communication system (quorum sensing). Here, we hypothesized that DMTU is able to inhibit multispecies biofilms. We developed a multispecies oral biofilm model, comprising an early colonizerStreptococcus gordonii, a bridge colonizerFusobacterium nucleatum, and late colonizersPorphyromonas gingivalisandAggregatibacter actinomycetemcomitans.We performed comprehensive investigations to demonstrate the effect of DMTU on planktonic cells and biofilms. Our findings showed that DMTU inhibits and disrupts multispecies biofilms without bactericidal effects. Mechanistic studies revealed a significant down regulation of biofilm and virulence-related genes inP. gingivalis. Taken together, our study highlights the potential of DMTU to inhibit polymicrobial biofilm communities and their virulence.
Persistent Identifierhttp://hdl.handle.net/10722/297670
ISSN
2023 Impact Factor: 4.1
2023 SCImago Journal Rankings: 0.944
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKalimuthu, S-
dc.contributor.authorCheung, BPK-
dc.contributor.authorYau, JYY-
dc.contributor.authorShanmugam, K-
dc.contributor.authorSolomon, AP-
dc.contributor.authorNeelakantan, P-
dc.date.accessioned2021-03-23T04:20:07Z-
dc.date.available2021-03-23T04:20:07Z-
dc.date.issued2020-
dc.identifier.citationMicroorganisms, 2020, v. 8 n. 9, p. article no. 1261-
dc.identifier.issn2076-2607-
dc.identifier.urihttp://hdl.handle.net/10722/297670-
dc.description.abstractAn imbalance of homeostasis between the microbial communities and the host system leads to dysbiosis in oral micro flora. DMTU (1,3-di-m-tolyl-urea) is a biocompatible compound that was shown to inhibitStreptococcus mutansbiofilm by inhibiting its communication system (quorum sensing). Here, we hypothesized that DMTU is able to inhibit multispecies biofilms. We developed a multispecies oral biofilm model, comprising an early colonizerStreptococcus gordonii, a bridge colonizerFusobacterium nucleatum, and late colonizersPorphyromonas gingivalisandAggregatibacter actinomycetemcomitans.We performed comprehensive investigations to demonstrate the effect of DMTU on planktonic cells and biofilms. Our findings showed that DMTU inhibits and disrupts multispecies biofilms without bactericidal effects. Mechanistic studies revealed a significant down regulation of biofilm and virulence-related genes inP. gingivalis. Taken together, our study highlights the potential of DMTU to inhibit polymicrobial biofilm communities and their virulence.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/microorganisms-
dc.relation.ispartofMicroorganisms-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectDMTU-
dc.subjectmultispecies biofilms-
dc.subjectPorphyromonas gingivalis-
dc.subjectquorum sensing-
dc.titleA Novel Small Molecule, 1,3-di-m-tolyl-urea, Inhibits and Disrupts Multispecies Oral Biofilms-
dc.typeArticle-
dc.identifier.emailCheung, BPK: bpkcheun@hkucc.hku.hk-
dc.identifier.emailYau, JYY: yaujyy@hku.hk-
dc.identifier.emailNeelakantan, P: prasanna@hku.hk-
dc.identifier.authorityNeelakantan, P=rp02214-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/microorganisms8091261-
dc.identifier.pmid32825310-
dc.identifier.pmcidPMC7570320-
dc.identifier.scopuseid_2-s2.0-85089693135-
dc.identifier.hkuros321917-
dc.identifier.volume8-
dc.identifier.issue9-
dc.identifier.spagearticle no. 1261-
dc.identifier.epagearticle no. 1261-
dc.identifier.isiWOS:000580836000001-
dc.publisher.placeSwitzerland-

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