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Article: Trans-cinnamaldehyde potently kills Enterococcus faecalis biofilm cells and prevents biofilm recovery

TitleTrans-cinnamaldehyde potently kills Enterococcus faecalis biofilm cells and prevents biofilm recovery
Authors
KeywordsAntibacterial
Biofilms
Enterococcus faecalis
Essential oils
Phenylpropanoid
Issue Date2020
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/micpath
Citation
Microbial Pathogenesis, 2020, v. 149, p. article no. 104482 How to Cite?
AbstractEnterococcus faecalis is a biofilm-forming, nosocomial pathogen that is frequently isolated from failed root canal treatments. Contemporary root canal disinfectants are ineffective in eliminating these biofilms and preventing reinfection. As a result, there is a pressing need to identify novel and safe antibiofilm molecules. The effect of short-term (5 and 15 min) and long-term (24 h) treatments of trans-cinnamaldehyde (TC) on the viability of E. faecalis biofilms was compared with currently used root canal disinfectants. Treatment for 15 min with TC reduced biofilm metabolic activity as effective as 1% sodium hypochlorite and 2% chlorhexidine. Treatment with TC for 24 h was significantly more effective than 2% chlorhexidine in reducing the viable cell counts of biofilms. This serendipitous effect of TC was sustained for 10 days under growth-favoring conditions. For the first time, our study highlights the strong antibacterial activity of TC against E. faecalis biofilms, and notably, its ability to prevent biofilm recovery after treatment.
Persistent Identifierhttp://hdl.handle.net/10722/297696
ISSN
2023 Impact Factor: 3.3
2023 SCImago Journal Rankings: 0.753
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorALI, IAA-
dc.contributor.authorCheung, BPK-
dc.contributor.authorMatinlinna, JP-
dc.contributor.authorLévesque, CM-
dc.contributor.authorNeelakantan, P-
dc.date.accessioned2021-03-23T04:20:23Z-
dc.date.available2021-03-23T04:20:23Z-
dc.date.issued2020-
dc.identifier.citationMicrobial Pathogenesis, 2020, v. 149, p. article no. 104482-
dc.identifier.issn0882-4010-
dc.identifier.urihttp://hdl.handle.net/10722/297696-
dc.description.abstractEnterococcus faecalis is a biofilm-forming, nosocomial pathogen that is frequently isolated from failed root canal treatments. Contemporary root canal disinfectants are ineffective in eliminating these biofilms and preventing reinfection. As a result, there is a pressing need to identify novel and safe antibiofilm molecules. The effect of short-term (5 and 15 min) and long-term (24 h) treatments of trans-cinnamaldehyde (TC) on the viability of E. faecalis biofilms was compared with currently used root canal disinfectants. Treatment for 15 min with TC reduced biofilm metabolic activity as effective as 1% sodium hypochlorite and 2% chlorhexidine. Treatment with TC for 24 h was significantly more effective than 2% chlorhexidine in reducing the viable cell counts of biofilms. This serendipitous effect of TC was sustained for 10 days under growth-favoring conditions. For the first time, our study highlights the strong antibacterial activity of TC against E. faecalis biofilms, and notably, its ability to prevent biofilm recovery after treatment.-
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/micpath-
dc.relation.ispartofMicrobial Pathogenesis-
dc.subjectAntibacterial-
dc.subjectBiofilms-
dc.subjectEnterococcus faecalis-
dc.subjectEssential oils-
dc.subjectPhenylpropanoid-
dc.titleTrans-cinnamaldehyde potently kills Enterococcus faecalis biofilm cells and prevents biofilm recovery-
dc.typeArticle-
dc.identifier.emailCheung, BPK: bpkcheun@hkucc.hku.hk-
dc.identifier.emailMatinlinna, JP: jpmat@hku.hk-
dc.identifier.emailNeelakantan, P: prasanna@hku.hk-
dc.identifier.authorityMatinlinna, JP=rp00052-
dc.identifier.authorityNeelakantan, P=rp02214-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.micpath.2020.104482-
dc.identifier.pmid32920147-
dc.identifier.scopuseid_2-s2.0-85090725068-
dc.identifier.hkuros321879-
dc.identifier.volume149-
dc.identifier.spagearticle no. 104482-
dc.identifier.epagearticle no. 104482-
dc.identifier.isiWOS:000599714100008-
dc.publisher.placeUnited Kingdom-

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