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- Publisher Website: 10.1097/00001756-199611040-00022
- Scopus: eid_2-s2.0-0029834430
- PMID: 8981414
- WOS: WOS:A1996WB71100022
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Article: Sulphonylureas reverse hypoxia induced K+-conductance increase in substantia nigra pars reticulata neurones
Title | Sulphonylureas reverse hypoxia induced K<sup>+</sup>-conductance increase in substantia nigra pars reticulata neurones |
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Authors | |
Keywords | Tolbutamide Hypoxia Glibenclamide ATP-sensitive potassium channels Nigra Substantia |
Issue Date | 1996 |
Citation | NeuroReport, 1996, v. 7, n. 15-17, p. 2513-2518 How to Cite? |
Abstract | Membrane potentials were recorded from neuronal somata in the substantia nigra pars reticulata of the rat midbrain slice using the whole-cell patch-clamp technique. Hypoxia induced a consistent decrease in input resistance often accompanied by membrane hyperpolarization and cessation of firing. The membrane hyperpolarization was mediated by K as indicated by its reversal potential at -88 ± 9 mV, which is close to the equilibrium potential of K . The hypoxic response was not sensitive to 1 μM tetrodotoxin or superfusion with Ca -free medium. While glibenclamide at 30 μM and tolbutamide at 300 μM had no effect on the resting membrane properties of the neurones, these sulphonylureas reversed the hypoxia-induced membrane hyperpolarization and restored firing. Inclusion of 2 mM of ATP in the recording pipette also prevented the hyperpolarization. These observations suggest that post-synaptic ATP-sensitive potassium channels exist the GABA neurones of SNR and that these channels are activated in energy-depleting conditions exemplified by hypoxia. + + 2+ |
Persistent Identifier | http://hdl.handle.net/10722/297961 |
ISSN | 2023 Impact Factor: 1.6 2023 SCImago Journal Rankings: 0.459 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wu, Cheok Wai | - |
dc.contributor.author | Leung, Chris K.S. | - |
dc.contributor.author | Yung, Wing Ho | - |
dc.date.accessioned | 2021-04-08T03:07:21Z | - |
dc.date.available | 2021-04-08T03:07:21Z | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | NeuroReport, 1996, v. 7, n. 15-17, p. 2513-2518 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.uri | http://hdl.handle.net/10722/297961 | - |
dc.description.abstract | Membrane potentials were recorded from neuronal somata in the substantia nigra pars reticulata of the rat midbrain slice using the whole-cell patch-clamp technique. Hypoxia induced a consistent decrease in input resistance often accompanied by membrane hyperpolarization and cessation of firing. The membrane hyperpolarization was mediated by K as indicated by its reversal potential at -88 ± 9 mV, which is close to the equilibrium potential of K . The hypoxic response was not sensitive to 1 μM tetrodotoxin or superfusion with Ca -free medium. While glibenclamide at 30 μM and tolbutamide at 300 μM had no effect on the resting membrane properties of the neurones, these sulphonylureas reversed the hypoxia-induced membrane hyperpolarization and restored firing. Inclusion of 2 mM of ATP in the recording pipette also prevented the hyperpolarization. These observations suggest that post-synaptic ATP-sensitive potassium channels exist the GABA neurones of SNR and that these channels are activated in energy-depleting conditions exemplified by hypoxia. + + 2+ | - |
dc.language | eng | - |
dc.relation.ispartof | NeuroReport | - |
dc.subject | Tolbutamide | - |
dc.subject | Hypoxia | - |
dc.subject | Glibenclamide | - |
dc.subject | ATP-sensitive potassium channels | - |
dc.subject | Nigra | - |
dc.subject | Substantia | - |
dc.title | Sulphonylureas reverse hypoxia induced K<sup>+</sup>-conductance increase in substantia nigra pars reticulata neurones | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1097/00001756-199611040-00022 | - |
dc.identifier.pmid | 8981414 | - |
dc.identifier.scopus | eid_2-s2.0-0029834430 | - |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 15-17 | - |
dc.identifier.spage | 2513 | - |
dc.identifier.epage | 2518 | - |
dc.identifier.isi | WOS:A1996WB71100022 | - |
dc.identifier.issnl | 0959-4965 | - |