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- Publisher Website: 10.1002/adma.200801586
- Scopus: eid_2-s2.0-60349102968
- WOS: WOS:000263737800008
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Article: Nanotopographic carbon nanotube thin-film substrate freezes lateral motion of secretory vesicles
| Title | Nanotopographic carbon nanotube thin-film substrate freezes lateral motion of secretory vesicles |
|---|---|
| Authors | |
| Issue Date | 2009 |
| Citation | Advanced Materials, 2009, v. 21, n. 7, p. 790-793 How to Cite? |
| Abstract | A study was conducted to examine the effects of a nanotopographic CNT substrate on the motion of secretory vesicles in neuronendocrine PC12 cells. It was observed that the nanotopography of CNT networks can affect specific cellular activity and vesicle-motion dynamics of all secretory cells including neurons, endocrine cells, osteoblasts, and immune cells. CNT substrates used for this study were coated with an adhesion-promoting polypeptide (poly(l-lysine)) to directly interact with cell membrane and adhesion proteins. It was found during the study that the cell morphology, growth, proliferation, differentiation, vesicle size and number, nature of vesicle motion, vesicle vertical trafficking, and vesicle dwell time remained unaffected by CNT substrates. The study provided a significant insight for understanding the biocompatibility between live cells and nanostructures. |
| Persistent Identifier | http://hdl.handle.net/10722/298471 |
| ISSN | 2021 Impact Factor: 32.086 2020 SCImago Journal Rankings: 10.707 |
| ISI Accession Number ID |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Zhang, Jing | - |
| dc.contributor.author | Fu, Dongliang | - |
| dc.contributor.author | Chan-Park, Mary B. | - |
| dc.contributor.author | Li, Lain Jong | - |
| dc.contributor.author | Chen, Peng | - |
| dc.date.accessioned | 2021-04-08T03:08:29Z | - |
| dc.date.available | 2021-04-08T03:08:29Z | - |
| dc.date.issued | 2009 | - |
| dc.identifier.citation | Advanced Materials, 2009, v. 21, n. 7, p. 790-793 | - |
| dc.identifier.issn | 0935-9648 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/298471 | - |
| dc.description.abstract | A study was conducted to examine the effects of a nanotopographic CNT substrate on the motion of secretory vesicles in neuronendocrine PC12 cells. It was observed that the nanotopography of CNT networks can affect specific cellular activity and vesicle-motion dynamics of all secretory cells including neurons, endocrine cells, osteoblasts, and immune cells. CNT substrates used for this study were coated with an adhesion-promoting polypeptide (poly(l-lysine)) to directly interact with cell membrane and adhesion proteins. It was found during the study that the cell morphology, growth, proliferation, differentiation, vesicle size and number, nature of vesicle motion, vesicle vertical trafficking, and vesicle dwell time remained unaffected by CNT substrates. The study provided a significant insight for understanding the biocompatibility between live cells and nanostructures. | - |
| dc.language | eng | - |
| dc.relation.ispartof | Advanced Materials | - |
| dc.title | Nanotopographic carbon nanotube thin-film substrate freezes lateral motion of secretory vesicles | - |
| dc.type | Article | - |
| dc.description.nature | link_to_subscribed_fulltext | - |
| dc.identifier.doi | 10.1002/adma.200801586 | - |
| dc.identifier.scopus | eid_2-s2.0-60349102968 | - |
| dc.identifier.volume | 21 | - |
| dc.identifier.issue | 7 | - |
| dc.identifier.spage | 790 | - |
| dc.identifier.epage | 793 | - |
| dc.identifier.isi | WOS:000263737800008 | - |
| dc.identifier.issnl | 0935-9648 | - |