Electrical detection of DNA hybridization with single-base specificity using transistors based on CVD-grown graphene sheets

Abstract

Large-sized chemical vapor deposited graphene films configured as solutiongated transistors can label-freely and electrically detect DNA hybridization with single-base specificity. The gate voltage which gives the minimum device conductance (V ) is sensitive to the charge transfer between DNA molecules and graphene, and thus is used to detect the DNA hybridization. The DNA detection is attributed to the electronic n-doping from DNA to graphene rather than the electrostatic gating effect or impurity screening effect. Chemical Equation Presentation © 2010 WILEY-VCH Verlag GmbH & Co. KGaA. g.min