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- Publisher Website: 10.1016/j.bios.2009.12.011
- Scopus: eid_2-s2.0-77952317291
- PMID: 20047826
- WOS: WOS:000275978700046
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Article: Integrating carbon nanotubes and lipid bilayer for biosensing
Title | Integrating carbon nanotubes and lipid bilayer for biosensing |
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Authors | |
Keywords | Membrane proteins Lipid bilayer Bioelectronics Carbon nanotubes |
Issue Date | 2010 |
Citation | Biosensors and Bioelectronics, 2010, v. 25, n. 7, p. 1834-1837 How to Cite? |
Abstract | Membrane proteins, which are the target of most drugs, are implicated in many critical cellular functions such as signal transduction, bioelectricity, exocytosis and endocytosis. Therefore, developing techniques to investigate the functions of membrane proteins is obviously important. Here, we have developed a novel system by integrating artificial lipid bilayer (biomimetic membrane) with single-walled carbon nanotube networks (SWNT-net) based field-effect transistor (FET), and demonstrated that such hybrid nanoelectronic biosensors can specifically and electronically detect the presence and dynamic activities of ionophores (specifically, gramicidin and calcimycin) in their native lipid environment. This technique can potentially be used to examine other membrane proteins (e.g. ligand-gated ion channels, receptors, membrane insertion toxins, and antibacterial peptides) for the purposes of biosensing, fundamental studies, or high throughput drug screening. © 2009 Elsevier B.V. |
Persistent Identifier | http://hdl.handle.net/10722/298495 |
ISSN | 2021 Impact Factor: 12.545 2020 SCImago Journal Rankings: 2.546 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Huang, Yinxi | - |
dc.contributor.author | Palkar, Preeti Vikas | - |
dc.contributor.author | Li, Lain Jong | - |
dc.contributor.author | Zhang, Hua | - |
dc.contributor.author | Chen, Peng | - |
dc.date.accessioned | 2021-04-08T03:08:37Z | - |
dc.date.available | 2021-04-08T03:08:37Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Biosensors and Bioelectronics, 2010, v. 25, n. 7, p. 1834-1837 | - |
dc.identifier.issn | 0956-5663 | - |
dc.identifier.uri | http://hdl.handle.net/10722/298495 | - |
dc.description.abstract | Membrane proteins, which are the target of most drugs, are implicated in many critical cellular functions such as signal transduction, bioelectricity, exocytosis and endocytosis. Therefore, developing techniques to investigate the functions of membrane proteins is obviously important. Here, we have developed a novel system by integrating artificial lipid bilayer (biomimetic membrane) with single-walled carbon nanotube networks (SWNT-net) based field-effect transistor (FET), and demonstrated that such hybrid nanoelectronic biosensors can specifically and electronically detect the presence and dynamic activities of ionophores (specifically, gramicidin and calcimycin) in their native lipid environment. This technique can potentially be used to examine other membrane proteins (e.g. ligand-gated ion channels, receptors, membrane insertion toxins, and antibacterial peptides) for the purposes of biosensing, fundamental studies, or high throughput drug screening. © 2009 Elsevier B.V. | - |
dc.language | eng | - |
dc.relation.ispartof | Biosensors and Bioelectronics | - |
dc.subject | Membrane proteins | - |
dc.subject | Lipid bilayer | - |
dc.subject | Bioelectronics | - |
dc.subject | Carbon nanotubes | - |
dc.title | Integrating carbon nanotubes and lipid bilayer for biosensing | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.bios.2009.12.011 | - |
dc.identifier.pmid | 20047826 | - |
dc.identifier.scopus | eid_2-s2.0-77952317291 | - |
dc.identifier.volume | 25 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 1834 | - |
dc.identifier.epage | 1837 | - |
dc.identifier.eissn | 1873-4235 | - |
dc.identifier.isi | WOS:000275978700046 | - |
dc.identifier.issnl | 0956-5663 | - |