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Article: Determinants of quantitative optic nerve measurements using spectral domain optical coherence tomography in a population-based sample of non-glaucomatous subjects

TitleDeterminants of quantitative optic nerve measurements using spectral domain optical coherence tomography in a population-based sample of non-glaucomatous subjects
Authors
Issue Date2011
Citation
Investigative Ophthalmology and Visual Science, 2011, v. 52, n. 13, p. 9629-9635 How to Cite?
AbstractPurpose. To evaluate the ocular and systemic factors influencing measurements of optic nerve head (ONH) parameters and retinal nerve fiber layer (RNFL) thickness with spectral-domain optical coherence tomography (SD-OCT) in healthy Chinese adults. Methods. Adults ranging in age from 40 to 80 years were consecutively recruited from the population-based Singapore Chinese Eye Study. A SD-OCT instrument was used to measure ONH and RNFL parameters. A total of 542 eyes from 542 non-glaucomatous Chinese subjects were analyzed. Univariable and multiple linear regression analyses were performed to examine the effects of a range of ocular (e.g., intraocular pressure [IOP], axial length [AL], disc area) and systemic (e.g., blood pressure, serum glucose) factors on ONH and RNFL parameters. Results. In multiple regression analyses, neuroretinal rim area was independently associated with age (β = -0.006, P < 0.001), disc area (β = 0.183, P < 0.001), IOP (β = -0.009, P = 0.008), AL (β = -0.023, P = 0.004), and lens nuclear color (β = 0.042, P = 0.001). Vertical cup-to-disc ratio was independently correlated with age (β = 0.003, P < 0.001), disc area (β = 0.207, P < 0.001), IOP (β = 0.004, P = 0.014), AL (β = 0.010, P = 0.008), and lens nuclear color (β = -0.017, P = 0.006). Average RNFL thickness was independently related to age (β = -0.204, P = 0.001), disc area (β = 4.218, P < 0.001), signal strength (β = 1.348, P < 0.001), and AL (β = -1.332, P < 0.001). Disc area had the strongest effect on measurements of ONH parameters and RNFL thickness. Conclusions. In a non-glaucomatous population, optic nerve measurements with SD-OCT vary with disc area, age, IOP, AL, lens nuclear color, and signal strength, but systemic parameters have little influence. This information may be useful for interpretation of SD-OCT measurements. © 2011 The Association for Research in Vision and Ophthalmology, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/298563
ISSN
2023 Impact Factor: 5.0
2023 SCImago Journal Rankings: 1.422
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, Carol Y.-
dc.contributor.authorChen, David-
dc.contributor.authorWong, Tien Y.-
dc.contributor.authorTham, Yih Chung-
dc.contributor.authorWu, Renyi-
dc.contributor.authorZheng, Yingfeng-
dc.contributor.authorCheng, Ching Yu-
dc.contributor.authorSaw, Seang Mei-
dc.contributor.authorBaskaran, Mani-
dc.contributor.authorLeung, Christopher K.-
dc.contributor.authorAung, Tin-
dc.date.accessioned2021-04-08T03:08:46Z-
dc.date.available2021-04-08T03:08:46Z-
dc.date.issued2011-
dc.identifier.citationInvestigative Ophthalmology and Visual Science, 2011, v. 52, n. 13, p. 9629-9635-
dc.identifier.issn0146-0404-
dc.identifier.urihttp://hdl.handle.net/10722/298563-
dc.description.abstractPurpose. To evaluate the ocular and systemic factors influencing measurements of optic nerve head (ONH) parameters and retinal nerve fiber layer (RNFL) thickness with spectral-domain optical coherence tomography (SD-OCT) in healthy Chinese adults. Methods. Adults ranging in age from 40 to 80 years were consecutively recruited from the population-based Singapore Chinese Eye Study. A SD-OCT instrument was used to measure ONH and RNFL parameters. A total of 542 eyes from 542 non-glaucomatous Chinese subjects were analyzed. Univariable and multiple linear regression analyses were performed to examine the effects of a range of ocular (e.g., intraocular pressure [IOP], axial length [AL], disc area) and systemic (e.g., blood pressure, serum glucose) factors on ONH and RNFL parameters. Results. In multiple regression analyses, neuroretinal rim area was independently associated with age (β = -0.006, P < 0.001), disc area (β = 0.183, P < 0.001), IOP (β = -0.009, P = 0.008), AL (β = -0.023, P = 0.004), and lens nuclear color (β = 0.042, P = 0.001). Vertical cup-to-disc ratio was independently correlated with age (β = 0.003, P < 0.001), disc area (β = 0.207, P < 0.001), IOP (β = 0.004, P = 0.014), AL (β = 0.010, P = 0.008), and lens nuclear color (β = -0.017, P = 0.006). Average RNFL thickness was independently related to age (β = -0.204, P = 0.001), disc area (β = 4.218, P < 0.001), signal strength (β = 1.348, P < 0.001), and AL (β = -1.332, P < 0.001). Disc area had the strongest effect on measurements of ONH parameters and RNFL thickness. Conclusions. In a non-glaucomatous population, optic nerve measurements with SD-OCT vary with disc area, age, IOP, AL, lens nuclear color, and signal strength, but systemic parameters have little influence. This information may be useful for interpretation of SD-OCT measurements. © 2011 The Association for Research in Vision and Ophthalmology, Inc.-
dc.languageeng-
dc.relation.ispartofInvestigative Ophthalmology and Visual Science-
dc.titleDeterminants of quantitative optic nerve measurements using spectral domain optical coherence tomography in a population-based sample of non-glaucomatous subjects-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1167/iovs.11-7481-
dc.identifier.pmid22039236-
dc.identifier.scopuseid_2-s2.0-84862833640-
dc.identifier.volume52-
dc.identifier.issue13-
dc.identifier.spage9629-
dc.identifier.epage9635-
dc.identifier.eissn1552-5783-
dc.identifier.isiWOS:000298628200053-
dc.identifier.issnl0146-0404-

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