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Article: Optic disc imaging with spectral-domain optical coherence tomography: Variability and agreement study with heidelberg retinal tomograph

TitleOptic disc imaging with spectral-domain optical coherence tomography: Variability and agreement study with heidelberg retinal tomograph
Authors
Issue Date2012
Citation
Ophthalmology, 2012, v. 119, n. 9, p. 1852-1857 How to Cite?
AbstractObjective: To evaluate the agreement of optic disc measurements obtained with the Cirrus high-density optical coherence tomography (HD-OCT) and the Heidelberg retina tomograph (HRT) and compare the intervisit, test-retest variability between the instruments. Design: Prospective, cross-sectional study. Participants: Two hundred seven subjects (109 glaucoma and 98 normal subjects). Methods: One eye from each individual was selected randomly for optic disc imaging by the Cirrus HD-OCT and the HRT. Areas of the optic disc and the cup, cup volume, vertical cup-to-disc ratio and cup-to-disc area ratio were compared between the instruments. The OCT measurements were corrected for ocular magnification using the Littman's formula. The measurement agreement was evaluated with the Bland-Altman plots. The intervisit test-retest variability was examined in 17 randomly selected glaucoma patients who underwent optic disc imaging weekly for 8 consecutive weeks. The intraclass correlation coefficients (ICC) and the reproducibility coefficients of the optic disc parameters were computed. Main Outcome Measures: Measurement agreement, reproducibility coefficients, and ICCs of optic disc parameters. Results: The OCT measured smaller optic disc and rim areas and greater cup volume, vertical cup-to-disc ratio and cup-to-disc area ratio than the HRT did (all with P<0.001). There were proportional biases in the Bland-Altman plots between OCT and HRT optic disc measurements except for rim area and cup-to-disc area ratio. The 95% limits of agreement of rim area ranged between -0.28 and 0.88 mm before, and between -0.22 and 0.92 mm after correction for ocular magnification. Both OCT and HRT showed high test-retest reproducibility with ICCs <0.921. Although the reproducibility coefficient of OCT rim area (0.093 mm ; 95% confidence interval [CI], 0.081-0.105 mm ) was significantly smaller than that of the HRT (0.186 mm ; 95% CI, 0.163-0.210 mm ; P =.018), there were no differences in the ICCs between the instruments. Conclusions: Optic disc assessment by spectral-domain OCT and confocal scanning laser ophthalmoscopy demonstrates poor agreement but similarly low test-retest variability. The source of their disagreement and its effects on the detection of progression require further study. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references. © 2012 American Academy of Ophthalmology. 2 2 2 2 2 2
Persistent Identifierhttp://hdl.handle.net/10722/298572
ISSN
2023 Impact Factor: 13.1
2023 SCImago Journal Rankings: 4.642
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYang, Bingzhi-
dc.contributor.authorYe, Cong-
dc.contributor.authorYu, Marco-
dc.contributor.authorLiu, Shu-
dc.contributor.authorLam, Dennis Shun Chiu-
dc.contributor.authorLeung, Christopher Kai Shun-
dc.date.accessioned2021-04-08T03:08:47Z-
dc.date.available2021-04-08T03:08:47Z-
dc.date.issued2012-
dc.identifier.citationOphthalmology, 2012, v. 119, n. 9, p. 1852-1857-
dc.identifier.issn0161-6420-
dc.identifier.urihttp://hdl.handle.net/10722/298572-
dc.description.abstractObjective: To evaluate the agreement of optic disc measurements obtained with the Cirrus high-density optical coherence tomography (HD-OCT) and the Heidelberg retina tomograph (HRT) and compare the intervisit, test-retest variability between the instruments. Design: Prospective, cross-sectional study. Participants: Two hundred seven subjects (109 glaucoma and 98 normal subjects). Methods: One eye from each individual was selected randomly for optic disc imaging by the Cirrus HD-OCT and the HRT. Areas of the optic disc and the cup, cup volume, vertical cup-to-disc ratio and cup-to-disc area ratio were compared between the instruments. The OCT measurements were corrected for ocular magnification using the Littman's formula. The measurement agreement was evaluated with the Bland-Altman plots. The intervisit test-retest variability was examined in 17 randomly selected glaucoma patients who underwent optic disc imaging weekly for 8 consecutive weeks. The intraclass correlation coefficients (ICC) and the reproducibility coefficients of the optic disc parameters were computed. Main Outcome Measures: Measurement agreement, reproducibility coefficients, and ICCs of optic disc parameters. Results: The OCT measured smaller optic disc and rim areas and greater cup volume, vertical cup-to-disc ratio and cup-to-disc area ratio than the HRT did (all with P<0.001). There were proportional biases in the Bland-Altman plots between OCT and HRT optic disc measurements except for rim area and cup-to-disc area ratio. The 95% limits of agreement of rim area ranged between -0.28 and 0.88 mm before, and between -0.22 and 0.92 mm after correction for ocular magnification. Both OCT and HRT showed high test-retest reproducibility with ICCs <0.921. Although the reproducibility coefficient of OCT rim area (0.093 mm ; 95% confidence interval [CI], 0.081-0.105 mm ) was significantly smaller than that of the HRT (0.186 mm ; 95% CI, 0.163-0.210 mm ; P =.018), there were no differences in the ICCs between the instruments. Conclusions: Optic disc assessment by spectral-domain OCT and confocal scanning laser ophthalmoscopy demonstrates poor agreement but similarly low test-retest variability. The source of their disagreement and its effects on the detection of progression require further study. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references. © 2012 American Academy of Ophthalmology. 2 2 2 2 2 2-
dc.languageeng-
dc.relation.ispartofOphthalmology-
dc.titleOptic disc imaging with spectral-domain optical coherence tomography: Variability and agreement study with heidelberg retinal tomograph-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ophtha.2012.02.033-
dc.identifier.pmid22572035-
dc.identifier.scopuseid_2-s2.0-84865676986-
dc.identifier.volume119-
dc.identifier.issue9-
dc.identifier.spage1852-
dc.identifier.epage1857-
dc.identifier.eissn1549-4713-
dc.identifier.isiWOS:000310581200020-
dc.identifier.issnl0161-6420-

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