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Article: Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: Interpreting the RNFL maps in healthy myopic eyes

TitleRetinal nerve fiber layer imaging with spectral-domain optical coherence tomography: Interpreting the RNFL maps in healthy myopic eyes
Authors
Issue Date2012
Citation
Investigative Ophthalmology and Visual Science, 2012, v. 53, n. 11, p. 7194-7200 How to Cite?
AbstractPURPOSE. To investigate the association between the distribution profile of the retinal nerve fiber layer (RNFL) bundles and myopia and its impact on interpretation of the RNFL map imaged by a spectral-domain optical coherence tomography (SD-OCT). METHODS. TheRNFL of 189myopic eyes from103 normal healthy myopic participants was imaged by an SD-OCT. The angle between the long axes of the superotemporal and inferotemporal RNFL bundles determined in the RNFL thickness map (the RNFL distribution angle) and the abnormal area in the RNFL thickness deviation map were measured. The associations between the RNFL distribution angle and the axial length/spherical error, and between the area of abnormal RNFL measurement and each of the following: axial length, spherical error, RNFL distribution angle, average RNFL thickness, optic disc area, and signal strength were analyzed with linear mixed models. RESULTS. The RNFL distribution angle decreased with the axial length (P < 0.011). In the univariate analysis, the area of abnormal RNFL measurement was positively associated with the axial length (P=0.001); and negatively associated with the RNFL distribution angle (P < 0.001), average RNFL thickness (P < 0.001), optic disc area (P ≤ 0.001), and signal strength (P = 0.026). In the multivariate analysis, the area of abnormal RNFL measurement was negatively associated with the RNFL distribution angle independent of other covariates. CONCLUSIONS. The superotemporal and inferotemporal RNFL bundles converged temporally with increasing myopia, which was associated with an increase in area of abnormal RNFL measurement. The interpretation of the RNFL thickness map in myopic eyes requires careful consideration of the distribution pattern of the RNFL bundles. © 2012 The Association for Research in Vision and Ophthalmology, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/298583
ISSN
2023 Impact Factor: 5.0
2023 SCImago Journal Rankings: 1.422
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, Christopher Kai Shun-
dc.contributor.authorYu, Marco-
dc.contributor.authorWeinreb, Robert N.-
dc.contributor.authorMak, Heather Kayew-
dc.contributor.authorLai, Gilda-
dc.contributor.authorYe, Cong-
dc.contributor.authorLam, Dennis Shun Chiu-
dc.date.accessioned2021-04-08T03:08:48Z-
dc.date.available2021-04-08T03:08:48Z-
dc.date.issued2012-
dc.identifier.citationInvestigative Ophthalmology and Visual Science, 2012, v. 53, n. 11, p. 7194-7200-
dc.identifier.issn0146-0404-
dc.identifier.urihttp://hdl.handle.net/10722/298583-
dc.description.abstractPURPOSE. To investigate the association between the distribution profile of the retinal nerve fiber layer (RNFL) bundles and myopia and its impact on interpretation of the RNFL map imaged by a spectral-domain optical coherence tomography (SD-OCT). METHODS. TheRNFL of 189myopic eyes from103 normal healthy myopic participants was imaged by an SD-OCT. The angle between the long axes of the superotemporal and inferotemporal RNFL bundles determined in the RNFL thickness map (the RNFL distribution angle) and the abnormal area in the RNFL thickness deviation map were measured. The associations between the RNFL distribution angle and the axial length/spherical error, and between the area of abnormal RNFL measurement and each of the following: axial length, spherical error, RNFL distribution angle, average RNFL thickness, optic disc area, and signal strength were analyzed with linear mixed models. RESULTS. The RNFL distribution angle decreased with the axial length (P < 0.011). In the univariate analysis, the area of abnormal RNFL measurement was positively associated with the axial length (P=0.001); and negatively associated with the RNFL distribution angle (P < 0.001), average RNFL thickness (P < 0.001), optic disc area (P ≤ 0.001), and signal strength (P = 0.026). In the multivariate analysis, the area of abnormal RNFL measurement was negatively associated with the RNFL distribution angle independent of other covariates. CONCLUSIONS. The superotemporal and inferotemporal RNFL bundles converged temporally with increasing myopia, which was associated with an increase in area of abnormal RNFL measurement. The interpretation of the RNFL thickness map in myopic eyes requires careful consideration of the distribution pattern of the RNFL bundles. © 2012 The Association for Research in Vision and Ophthalmology, Inc.-
dc.languageeng-
dc.relation.ispartofInvestigative Ophthalmology and Visual Science-
dc.titleRetinal nerve fiber layer imaging with spectral-domain optical coherence tomography: Interpreting the RNFL maps in healthy myopic eyes-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1167/iovs.12-9726-
dc.identifier.pmid22997288-
dc.identifier.scopuseid_2-s2.0-84872009490-
dc.identifier.volume53-
dc.identifier.issue11-
dc.identifier.spage7194-
dc.identifier.epage7200-
dc.identifier.eissn1552-5783-
dc.identifier.isiWOS:000310589900064-
dc.identifier.f1000717960175-
dc.identifier.issnl0146-0404-

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