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Conference Paper: Long Wavelength Light-triggered Drug Rlease Based on Triplet-triplet Energy Transfer
Title | Long Wavelength Light-triggered Drug Rlease Based on Triplet-triplet Energy Transfer |
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Authors | |
Issue Date | 2019 |
Citation | 10th International Conference on Materials for Advanced Technologies (ICMAT 2019), Singapore, 23-28 June 2019 How to Cite? |
Abstract | We develop a new strategy that adopts long wavelength light-excitable photosensitizers to activate the cleavage of photocleavable prodrugs. The prodrugs are cleaved to release free drugs at their triplet excited (T1) state which is activated by photosensitizers through triplet-triplet energy transfer (TTET) process. We demonstrate that this strategy can increase the excitation wavelength while minimize the sacrifices of photocleavage quantum yield. This long wavelength light-triggered photocleavage strategy offers new solutions for spatiotemporal control of drug release. |
Description | Organizer: Materials Research Society of Singapore (MRS-S) |
Persistent Identifier | http://hdl.handle.net/10722/298645 |
DC Field | Value | Language |
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dc.contributor.author | Lyu, W | - |
dc.contributor.author | Wang, W | - |
dc.date.accessioned | 2021-04-09T07:56:19Z | - |
dc.date.available | 2021-04-09T07:56:19Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | 10th International Conference on Materials for Advanced Technologies (ICMAT 2019), Singapore, 23-28 June 2019 | - |
dc.identifier.uri | http://hdl.handle.net/10722/298645 | - |
dc.description | Organizer: Materials Research Society of Singapore (MRS-S) | - |
dc.description.abstract | We develop a new strategy that adopts long wavelength light-excitable photosensitizers to activate the cleavage of photocleavable prodrugs. The prodrugs are cleaved to release free drugs at their triplet excited (T1) state which is activated by photosensitizers through triplet-triplet energy transfer (TTET) process. We demonstrate that this strategy can increase the excitation wavelength while minimize the sacrifices of photocleavage quantum yield. This long wavelength light-triggered photocleavage strategy offers new solutions for spatiotemporal control of drug release. | - |
dc.language | eng | - |
dc.relation.ispartof | 10th International Conference on Materials for Advanced Technologies (ICMAT 2019) | - |
dc.title | Long Wavelength Light-triggered Drug Rlease Based on Triplet-triplet Energy Transfer | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Lyu, W: lyuwen@hku.hk | - |
dc.identifier.email | Wang, W: wangwp@hku.hk | - |
dc.identifier.authority | Wang, W=rp02227 | - |
dc.identifier.hkuros | 302214 | - |