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Article: AdipoRon Treatment Induces a Dose-Dependent Response in Adult Hippocampal Neurogenesis

TitleAdipoRon Treatment Induces a Dose-Dependent Response in Adult Hippocampal Neurogenesis
Authors
KeywordsAdipoRon
hippocampal neurogenesis
learning and memory
adiponectin
brain-derived neurotrophic factor
Issue Date2021
PublisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms
Citation
International Journal of Molecular Sciences, 2021, v. 22 n. 4, p. article no. 2068 How to Cite?
AbstractAdipoRon, an adiponectin receptor agonist, elicits similar antidiabetic, anti-atherogenic, and anti-inflammatory effects on mouse models as adiponectin does. Since AdipoRon can cross the blood-brain barrier, its chronic effects on regulating hippocampal function are yet to be examined. This study investigated whether AdipoRon treatment promotes hippocampal neurogenesis and spatial recognition memory in a dose-dependent manner. Adolescent male C57BL/6J mice received continuous treatment of either 20 mg/kg (low dose) or 50 mg/kg (high dose) AdipoRon or vehicle intraperitoneally for 14 days, followed by the open field test to examine anxiety and locomotor activity, and the Y maze test to examine hippocampal-dependent spatial recognition memory. Immunopositive cell markers of neural progenitor cells, immature neurons, and newborn cells in the hippocampal dentate gyrus were quantified. Immunosorbent assays were used to measure the serum levels of factors that can regulate hippocampal neurogenesis, including adiponectin, brain-derived neurotrophic factor (BDNF), and corticosterone. Our results showed that 20 mg/kg AdipoRon treatment significantly promoted hippocampal cell proliferation and increased serum levels of adiponectin and BDNF, though there were no effects on spatial recognition memory and locomotor activity. On the contrary, 50 mg/kg AdipoRon treatment impaired spatial recognition memory, suppressed cell proliferation, neuronal differentiation, and cell survival associated with reduced serum levels of BDNF and adiponectin. The results suggest that a low-dose AdipoRon treatment promotes hippocampal cell proliferation, while a high-dose AdipoRon treatment is detrimental to the hippocampus function.
Persistent Identifierhttp://hdl.handle.net/10722/298660
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.179
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, TH-
dc.contributor.authorChristie, BR-
dc.contributor.authorvan Praag, H-
dc.contributor.authorLin, K-
dc.contributor.authorSiu, PMF-
dc.contributor.authorXu, A-
dc.contributor.authorSo, KF-
dc.contributor.authorYau, SY-
dc.date.accessioned2021-04-12T03:01:37Z-
dc.date.available2021-04-12T03:01:37Z-
dc.date.issued2021-
dc.identifier.citationInternational Journal of Molecular Sciences, 2021, v. 22 n. 4, p. article no. 2068-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/10722/298660-
dc.description.abstractAdipoRon, an adiponectin receptor agonist, elicits similar antidiabetic, anti-atherogenic, and anti-inflammatory effects on mouse models as adiponectin does. Since AdipoRon can cross the blood-brain barrier, its chronic effects on regulating hippocampal function are yet to be examined. This study investigated whether AdipoRon treatment promotes hippocampal neurogenesis and spatial recognition memory in a dose-dependent manner. Adolescent male C57BL/6J mice received continuous treatment of either 20 mg/kg (low dose) or 50 mg/kg (high dose) AdipoRon or vehicle intraperitoneally for 14 days, followed by the open field test to examine anxiety and locomotor activity, and the Y maze test to examine hippocampal-dependent spatial recognition memory. Immunopositive cell markers of neural progenitor cells, immature neurons, and newborn cells in the hippocampal dentate gyrus were quantified. Immunosorbent assays were used to measure the serum levels of factors that can regulate hippocampal neurogenesis, including adiponectin, brain-derived neurotrophic factor (BDNF), and corticosterone. Our results showed that 20 mg/kg AdipoRon treatment significantly promoted hippocampal cell proliferation and increased serum levels of adiponectin and BDNF, though there were no effects on spatial recognition memory and locomotor activity. On the contrary, 50 mg/kg AdipoRon treatment impaired spatial recognition memory, suppressed cell proliferation, neuronal differentiation, and cell survival associated with reduced serum levels of BDNF and adiponectin. The results suggest that a low-dose AdipoRon treatment promotes hippocampal cell proliferation, while a high-dose AdipoRon treatment is detrimental to the hippocampus function.-
dc.languageeng-
dc.publisherMolecular Diversity Preservation International. The Journal's web site is located at http://www.mdpi.org/ijms-
dc.relation.ispartofInternational Journal of Molecular Sciences-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAdipoRon-
dc.subjecthippocampal neurogenesis-
dc.subjectlearning and memory-
dc.subjectadiponectin-
dc.subjectbrain-derived neurotrophic factor-
dc.titleAdipoRon Treatment Induces a Dose-Dependent Response in Adult Hippocampal Neurogenesis-
dc.typeArticle-
dc.identifier.emailSiu, PMF: pmsiu@hku.hk-
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.emailSo, KF: hrmaskf@hku.hk-
dc.identifier.authoritySiu, PMF=rp02292-
dc.identifier.authorityXu, A=rp00485-
dc.identifier.authoritySo, KF=rp00329-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/ijms22042068-
dc.identifier.pmid33669795-
dc.identifier.pmcidPMC7922380-
dc.identifier.scopuseid_2-s2.0-85100919857-
dc.identifier.hkuros321988-
dc.identifier.volume22-
dc.identifier.issue4-
dc.identifier.spagearticle no. 2068-
dc.identifier.epagearticle no. 2068-
dc.identifier.isiWOS:000623765700001-
dc.publisher.placeSwitzerland-

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