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Article: Multifunctional SDF-1-loaded hydroxyapatite/polylactic acid membranes promote cell recruitment, immunomodulation, angiogenesis, and osteogenesis for biomimetic bone regeneration

TitleMultifunctional SDF-1-loaded hydroxyapatite/polylactic acid membranes promote cell recruitment, immunomodulation, angiogenesis, and osteogenesis for biomimetic bone regeneration
Authors
KeywordsAngiogenesis and osteogenesis
Biomimetic repair
Cell recruitment
Immunomodulation
Multifactor regulation
Issue Date2021
PublisherElsevier BV. The Journal's web site is located at http://www.journals.elsevier.com/applied-materials-today
Citation
Applied Materials Today, 2021, v. 22, p. article no. 100942 How to Cite?
AbstractBone repair is a complex and multifactorial regulatory process, and achieving precise and efficient bone regeneration is a fundamental goal of bone tissue engineering. Promoting the synergistic effects of cell recruitment, immunomodulation, angiogenesis, and osteogenesis is a feasible strategy to augment bone repair. In this work, the multifunctional agent stromal cell-derived factor-1 (SDF-1) was loaded onto hydroxyapatite (HAp) nanowires and observed to endow HAp/polylactic acid (PLA) (HP) membrane with versatile capabilities for efficient guided bone regeneration. After being loaded onto HAp nanowires by physical and electrostatic adsorption, SDF-1 showed a relatively rapid release during the early period of bone regeneration and a slow-release during the later period. At the initial stage of bone repair, the SDF-1-HAp/PLA (S-HP) membrane promoted endogenous cell recruitment and macrophage M2 polarization. Later, the S-HP membrane facilitated vessel formation and finally enhanced mature bone regeneration. Therefore, the S-HP membrane could efficiently promote precise and oriented bone tissue regeneration through its synergistic multifunctional effects, demonstrating that this scaffold possesses great potential in guided tissue regeneration and provides guidance for the design of other functional biomaterials.
Persistent Identifierhttp://hdl.handle.net/10722/298744
ISSN
2023 Impact Factor: 7.2
2023 SCImago Journal Rankings: 1.623
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, X-
dc.contributor.authorWei, L-
dc.contributor.authorLi, J-
dc.contributor.authorShao, J-
dc.contributor.authorYI, B-
dc.contributor.authorZhang, C-
dc.contributor.authorLiu, H-
dc.contributor.authorMa, B-
dc.contributor.authorGe, S-
dc.date.accessioned2021-04-12T03:02:47Z-
dc.date.available2021-04-12T03:02:47Z-
dc.date.issued2021-
dc.identifier.citationApplied Materials Today, 2021, v. 22, p. article no. 100942-
dc.identifier.issn2352-9407-
dc.identifier.urihttp://hdl.handle.net/10722/298744-
dc.description.abstractBone repair is a complex and multifactorial regulatory process, and achieving precise and efficient bone regeneration is a fundamental goal of bone tissue engineering. Promoting the synergistic effects of cell recruitment, immunomodulation, angiogenesis, and osteogenesis is a feasible strategy to augment bone repair. In this work, the multifunctional agent stromal cell-derived factor-1 (SDF-1) was loaded onto hydroxyapatite (HAp) nanowires and observed to endow HAp/polylactic acid (PLA) (HP) membrane with versatile capabilities for efficient guided bone regeneration. After being loaded onto HAp nanowires by physical and electrostatic adsorption, SDF-1 showed a relatively rapid release during the early period of bone regeneration and a slow-release during the later period. At the initial stage of bone repair, the SDF-1-HAp/PLA (S-HP) membrane promoted endogenous cell recruitment and macrophage M2 polarization. Later, the S-HP membrane facilitated vessel formation and finally enhanced mature bone regeneration. Therefore, the S-HP membrane could efficiently promote precise and oriented bone tissue regeneration through its synergistic multifunctional effects, demonstrating that this scaffold possesses great potential in guided tissue regeneration and provides guidance for the design of other functional biomaterials.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.journals.elsevier.com/applied-materials-today-
dc.relation.ispartofApplied Materials Today-
dc.subjectAngiogenesis and osteogenesis-
dc.subjectBiomimetic repair-
dc.subjectCell recruitment-
dc.subjectImmunomodulation-
dc.subjectMultifactor regulation-
dc.titleMultifunctional SDF-1-loaded hydroxyapatite/polylactic acid membranes promote cell recruitment, immunomodulation, angiogenesis, and osteogenesis for biomimetic bone regeneration-
dc.typeArticle-
dc.identifier.emailZhang, C: zhangcf@hku.hk-
dc.identifier.authorityZhang, C=rp01408-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.apmt.2021.100942-
dc.identifier.scopuseid_2-s2.0-85100120947-
dc.identifier.hkuros321930-
dc.identifier.volume22-
dc.identifier.spagearticle no. 100942-
dc.identifier.epagearticle no. 100942-
dc.identifier.isiWOS:000632615800007-
dc.publisher.placeNetherlands-

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