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- Publisher Website: 10.1097/moo.0000000000000687
- Scopus: eid_2-s2.0-85102657458
- PMID: 33278136
- WOS: WOS:000662031700003
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Article: Treatment of persistent/recurrent nodal disease in nasopharyngeal cancer
Title | Treatment of persistent/recurrent nodal disease in nasopharyngeal cancer |
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Authors | |
Keywords | nasopharyngeal carcinoma neck dissection regional failure salvage surgery salvage treatment |
Issue Date | 2021 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.co-otolaryngology.com |
Citation | Current Opinion in Otolaryngology & Head and Neck Surgery, 2021, v. 29 n. 2, p. 86-92 How to Cite? |
Abstract | Purpose of review:
Persistent or recurrent disease in the neck lymphatics is an unusual pattern of failure in nasopharyngeal carcinoma (NPC) after definitive radiotherapy or chemoradiotherapy. The purpose of this review is to critically synthesize the current knowledge regarding salvage treatment of this unique form of failure in NPC.
Recent findings:
Surgery in the form of radical neck dissection has been established as the standard salvage treatment with 5-year regional control of 60--86%. Recent shift in paradigm has resulted in the use of modified or selective neck dissection as salvage surgery in some centers. Risk factors for poor survival outcome include recurrent nodal disease, number of involved lymph nodes, extracapsular extension, high lymph node ratio, and positive resection margin. There are no well controlled studies on the role of additional radiotherapy or chemotherapy to improve local control or survival after salvage neck dissection in this group of patients with regional failure.
Summary:
There is limited literature regarding the extent of surgical dissection in treating nodal persistent or recurrent disease. Prospective studies are also needed to determine whether adjuvant therapy improves treatment outcomes. |
Persistent Identifier | http://hdl.handle.net/10722/298774 |
ISSN | 2023 Impact Factor: 1.9 2023 SCImago Journal Rankings: 0.601 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tsang, RK | - |
dc.contributor.author | Ng, WT | - |
dc.date.accessioned | 2021-04-12T03:03:11Z | - |
dc.date.available | 2021-04-12T03:03:11Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Current Opinion in Otolaryngology & Head and Neck Surgery, 2021, v. 29 n. 2, p. 86-92 | - |
dc.identifier.issn | 1068-9508 | - |
dc.identifier.uri | http://hdl.handle.net/10722/298774 | - |
dc.description.abstract | Purpose of review: Persistent or recurrent disease in the neck lymphatics is an unusual pattern of failure in nasopharyngeal carcinoma (NPC) after definitive radiotherapy or chemoradiotherapy. The purpose of this review is to critically synthesize the current knowledge regarding salvage treatment of this unique form of failure in NPC. Recent findings: Surgery in the form of radical neck dissection has been established as the standard salvage treatment with 5-year regional control of 60--86%. Recent shift in paradigm has resulted in the use of modified or selective neck dissection as salvage surgery in some centers. Risk factors for poor survival outcome include recurrent nodal disease, number of involved lymph nodes, extracapsular extension, high lymph node ratio, and positive resection margin. There are no well controlled studies on the role of additional radiotherapy or chemotherapy to improve local control or survival after salvage neck dissection in this group of patients with regional failure. Summary: There is limited literature regarding the extent of surgical dissection in treating nodal persistent or recurrent disease. Prospective studies are also needed to determine whether adjuvant therapy improves treatment outcomes. | - |
dc.language | eng | - |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.co-otolaryngology.com | - |
dc.relation.ispartof | Current Opinion in Otolaryngology & Head and Neck Surgery | - |
dc.rights | This is a non-final version of an article published in final form in (provide complete journal citation) | - |
dc.subject | nasopharyngeal carcinoma | - |
dc.subject | neck dissection | - |
dc.subject | regional failure | - |
dc.subject | salvage surgery | - |
dc.subject | salvage treatment | - |
dc.title | Treatment of persistent/recurrent nodal disease in nasopharyngeal cancer | - |
dc.type | Article | - |
dc.identifier.email | Tsang, RK: rkytsang@hku.hk | - |
dc.identifier.authority | Tsang, RK=rp01386 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1097/moo.0000000000000687 | - |
dc.identifier.pmid | 33278136 | - |
dc.identifier.scopus | eid_2-s2.0-85102657458 | - |
dc.identifier.hkuros | 322022 | - |
dc.identifier.volume | 29 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 86 | - |
dc.identifier.epage | 92 | - |
dc.identifier.isi | WOS:000662031700003 | - |
dc.publisher.place | United States | - |