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Article: GABA supplementation negatively affects cognitive flexibility independent of tyrosine

TitleGABA supplementation negatively affects cognitive flexibility independent of tyrosine
Authors
Keywordstyrosine
GABA
dopamine
reinforcement
cognitive flexibility
Issue Date2021
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/jcm
Citation
Journal of Clinical Medicine, , v. 10 n. 9, p. article no. 1807 How to Cite?
AbstractIncreasing evidence, particularly from animal studies, suggests that dopamine and GABA are important modulators of cognitive flexibility. In humans, increasing dopamine synthesis through its precursor tyrosine has been shown to result in performance improvements, but few studies have reported the effects of GABA supplementation in healthy participants. We conducted a double-blind, placebo-controlled, randomized experiment to test the interactive effects of tyrosine and GABA administration on two measures of cognitive flexibility, response inhibition and task switching. A total of 48 healthy volunteers were split into four groups (placebo, tyrosine alone, GABA alone, and tyrosine and GABA combined). They completed cognitive flexibility tasks at baseline and after drug administration. We found that tyrosine alone had no impact on the measures of cognitive flexibility, whereas GABA alone and in combination with tyrosine worsened task switching. Our results provide preliminary evidence that putative increases in GABA and dopamine synthesis do not interact to affect cognitive flexibility performance.
Persistent Identifierhttp://hdl.handle.net/10722/299067
ISSN
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 0.882
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLim, LW-
dc.contributor.authorAquili, L-
dc.date.accessioned2021-04-28T02:25:46Z-
dc.date.available2021-04-28T02:25:46Z-
dc.date.issued2021-
dc.identifier.citationJournal of Clinical Medicine, , v. 10 n. 9, p. article no. 1807-
dc.identifier.issn2077-0383-
dc.identifier.urihttp://hdl.handle.net/10722/299067-
dc.description.abstractIncreasing evidence, particularly from animal studies, suggests that dopamine and GABA are important modulators of cognitive flexibility. In humans, increasing dopamine synthesis through its precursor tyrosine has been shown to result in performance improvements, but few studies have reported the effects of GABA supplementation in healthy participants. We conducted a double-blind, placebo-controlled, randomized experiment to test the interactive effects of tyrosine and GABA administration on two measures of cognitive flexibility, response inhibition and task switching. A total of 48 healthy volunteers were split into four groups (placebo, tyrosine alone, GABA alone, and tyrosine and GABA combined). They completed cognitive flexibility tasks at baseline and after drug administration. We found that tyrosine alone had no impact on the measures of cognitive flexibility, whereas GABA alone and in combination with tyrosine worsened task switching. Our results provide preliminary evidence that putative increases in GABA and dopamine synthesis do not interact to affect cognitive flexibility performance.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/jcm-
dc.relation.ispartofJournal of Clinical Medicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjecttyrosine-
dc.subjectGABA-
dc.subjectdopamine-
dc.subjectreinforcement-
dc.subjectcognitive flexibility-
dc.titleGABA supplementation negatively affects cognitive flexibility independent of tyrosine-
dc.typeArticle-
dc.identifier.emailLim, LW: limlw@hku.hk-
dc.identifier.authorityLim, LW=rp02088-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/jcm10091807-
dc.identifier.pmid33919136-
dc.identifier.pmcidPMC8122390-
dc.identifier.scopuseid_2-s2.0-85114078218-
dc.identifier.hkuros322276-
dc.identifier.volume10-
dc.identifier.issue9-
dc.identifier.spagearticle no. 1807-
dc.identifier.epagearticle no. 1807-
dc.identifier.isiWOS:000650427100001-
dc.publisher.placeSwitzerland-

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