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Article: Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy

TitleSomatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy
Authors
Issue Date2021
PublisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html
Citation
Nature Communications, 2021, v. 12 n. 1, p. article no. 117 How to Cite?
AbstractNasopharyngeal cancer (NPC), endemic in Southeast Asia, lacks effective diagnostic and therapeutic strategies. Even in high-income countries the 5-year survival rate for stage IV NPC is less than 40%. Here we report high somatostatin receptor 2 (SSTR2) expression in multiple clinical cohorts comprising 402 primary, locally recurrent and metastatic NPCs. We show that SSTR2 expression is induced by the Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) via the NF-κB pathway. Using cell-based and preclinical rodent models, we demonstrate the therapeutic potential of SSTR2 targeting using a cytotoxic drug conjugate, PEN-221, which is found to be superior to FDA-approved SSTR2-binding cytostatic agents. Furthermore, we reveal significant correlation of SSTR expression with increased rates of survival and report in vivo uptake of the SSTR2-binding 68Ga-DOTA-peptide radioconjugate in PET-CT scanning in a clinical trial of NPC patients (NCT03670342). These findings reveal a key role in EBV-associated NPC for SSTR2 in infection, imaging, targeted therapy and survival.
Persistent Identifierhttp://hdl.handle.net/10722/299353
ISSN
2020 Impact Factor: 14.919
2015 SCImago Journal Rankings: 6.539
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLechner, M-
dc.contributor.authorSchartinger, VH-
dc.contributor.authorSchartinger, CD-
dc.contributor.authorNei, WL-
dc.contributor.authorOoft, ML-
dc.contributor.authorSchreiber, LM-
dc.contributor.authorPipinikas, CP-
dc.contributor.authorChung, GTY-
dc.contributor.authorChan, YY-
dc.contributor.authorWu, F-
dc.contributor.authorTo, KF-
dc.contributor.authorTsang, CM-
dc.contributor.authorPearce, W-
dc.contributor.authorMorelli, D-
dc.contributor.authorPhilpott, M-
dc.contributor.authorMasterson, L-
dc.contributor.authorNibhani, R-
dc.contributor.authorWells, G-
dc.contributor.authorBell, CG-
dc.contributor.authorKoller, J-
dc.contributor.authorDelecluse, S-
dc.contributor.authorYip, YL-
dc.contributor.authorLiu, J-
dc.contributor.authorForde, CT-
dc.contributor.authorForster, MD-
dc.contributor.authorJay, A-
dc.contributor.authorDudás, J-
dc.contributor.authorKrapp, A-
dc.contributor.authorWan, S-
dc.contributor.authorUprimny, C-
dc.contributor.authorSprung, S-
dc.contributor.authorHaybaeck, J-
dc.contributor.authorFenton, TR-
dc.contributor.authorChester, K-
dc.contributor.authorThirlwell, C-
dc.contributor.authorRoyle, G-
dc.contributor.authorMarafioti, T-
dc.contributor.authorGupta, R-
dc.contributor.authorIndrasari, SR-
dc.contributor.authorHerdini, C-
dc.contributor.authorSlim, MAM-
dc.contributor.authorIndrawati, I-
dc.contributor.authorSutton, L-
dc.contributor.authorFles, R-
dc.contributor.authorTan, B-
dc.contributor.authorYeong, J-
dc.contributor.authorJain, A-
dc.contributor.authorHan, S-
dc.contributor.authorWang, H-
dc.contributor.authorLoke, KSH-
dc.contributor.authorHe, W-
dc.contributor.authorXu, R-
dc.contributor.authorJin, H-
dc.contributor.authorCheng, Z-
dc.contributor.authorHoward, D-
dc.contributor.authorHwang, PH-
dc.contributor.authorLe, QT-
dc.contributor.authorTay, JK-
dc.contributor.authorWest, RB-
dc.contributor.authorTsao, SW-
dc.contributor.authorMeyer, T-
dc.contributor.authorRiechelmann, H-
dc.contributor.authorOppermann, U-
dc.contributor.authorDelecluse, HJ-
dc.contributor.authorWillems, SM-
dc.contributor.authorChua, MLK-
dc.contributor.authorBusson, P-
dc.contributor.authorLo, KW-
dc.contributor.authorWollmann, G-
dc.contributor.authorPillay, N-
dc.contributor.authorVanhaesebroeck, B-
dc.contributor.authorLund, VJ-
dc.date.accessioned2021-05-10T07:00:35Z-
dc.date.available2021-05-10T07:00:35Z-
dc.date.issued2021-
dc.identifier.citationNature Communications, 2021, v. 12 n. 1, p. article no. 117-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/299353-
dc.description.abstractNasopharyngeal cancer (NPC), endemic in Southeast Asia, lacks effective diagnostic and therapeutic strategies. Even in high-income countries the 5-year survival rate for stage IV NPC is less than 40%. Here we report high somatostatin receptor 2 (SSTR2) expression in multiple clinical cohorts comprising 402 primary, locally recurrent and metastatic NPCs. We show that SSTR2 expression is induced by the Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) via the NF-κB pathway. Using cell-based and preclinical rodent models, we demonstrate the therapeutic potential of SSTR2 targeting using a cytotoxic drug conjugate, PEN-221, which is found to be superior to FDA-approved SSTR2-binding cytostatic agents. Furthermore, we reveal significant correlation of SSTR expression with increased rates of survival and report in vivo uptake of the SSTR2-binding 68Ga-DOTA-peptide radioconjugate in PET-CT scanning in a clinical trial of NPC patients (NCT03670342). These findings reveal a key role in EBV-associated NPC for SSTR2 in infection, imaging, targeted therapy and survival.-
dc.languageeng-
dc.publisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html-
dc.relation.ispartofNature Communications-
dc.rightsNature Communications. Copyright © Nature Research: Fully open access journals.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleSomatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy-
dc.typeArticle-
dc.identifier.emailYip, YL: yimling@hku.hk-
dc.identifier.emailTsao, SW: gswtsao@hku.hk-
dc.identifier.authorityTsao, SW=rp00399-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41467-020-20308-8-
dc.identifier.pmid33402692-
dc.identifier.pmcidPMC7785735-
dc.identifier.scopuseid_2-s2.0-85098775242-
dc.identifier.hkuros322427-
dc.identifier.volume12-
dc.identifier.issue1-
dc.identifier.spagearticle no. 117-
dc.identifier.epagearticle no. 117-
dc.identifier.isiWOS:000610428500001-
dc.publisher.placeUnited Kingdom-

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