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Article: Effectiveness of Microcurrent Stimulation in Preserving Retinal Function of Blind Leading Retinal Degeneration and Optic Neuropathy: A Systematic Review

TitleEffectiveness of Microcurrent Stimulation in Preserving Retinal Function of Blind Leading Retinal Degeneration and Optic Neuropathy: A Systematic Review
Authors
KeywordsElectrical phosphene threshold
electrical stimulation
neuroprotection
retinal degeneration
visual function
Issue Date2021
PublisherBlackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1525-1403
Citation
Neuromodulation, 2021, Epub 2021-05-13 How to Cite?
AbstractObjectives To systematically identify and summarize the effectiveness and the parameters of electrical stimulation (ES) for the preservation of visual function in major retinal degeneration and optic neuropathy. Materials and Methods A systematic review of clinical studies, using ES therapy in patients with blind leading retinal degenerations, including retinitis pigmentosa (RP), age‐related macular degeneration (AMD), glaucoma, retinal vein occlusion (RVO), retinal artery occlusion (RAO), and optic neuropathy was conducted. PubMed, EMBASE, Cochrane Library, and Web of Science were searched for relevant interventional studies including randomized controlled trials (RCTs) and observational studies. Results A total of 10 RCTs and 15 observational studies were included. Transcorneal ES (TcES), transpalpebral ES (TpES), transdermal ES (TdES), and repetitive transorbital alternating current stimulation (rtACS) were used for the treatment of the patients. ES using 20 Hz biphasic pulses with current strength at 150%–200% of individual electrical phosphene threshold (EPT) for RP patients showed improved retinal function detected by visual acuity (VA), visual field (VF), or electrical retinal graphs (ERG). rtACS on patients with optic neuropathy showed significant preservation of VA and VF. Clinical studies on AMD, RAO, and glaucoma indicated promising protective effects of ES on the visual function, though the amount of evidence is limited. Conclusions ES treatment has promising therapeutic effects on RP and optic neuropathy. More large‐scale RCT studies should be conducted to elucidate the potential of ES, especially on AMD, RAO, and glaucoma. A comparison of the effects by different ES methods in the same disease populations is still lacking. Parameters of the electric current and sensitive detection method should be optimized for the evaluation of ES treatment effects in future studies.
Persistent Identifierhttp://hdl.handle.net/10722/299688
ISSN
2023 Impact Factor: 3.2
2023 SCImago Journal Rankings: 0.919
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLIU, J-
dc.contributor.authorTong, K-
dc.contributor.authorLIN, Y-
dc.contributor.authorLee, VWH-
dc.contributor.authorSo, KF-
dc.contributor.authorShih, KC-
dc.contributor.authorLai, JSM-
dc.contributor.authorChiu, K-
dc.date.accessioned2021-05-26T03:27:39Z-
dc.date.available2021-05-26T03:27:39Z-
dc.date.issued2021-
dc.identifier.citationNeuromodulation, 2021, Epub 2021-05-13-
dc.identifier.issn1094-7159-
dc.identifier.urihttp://hdl.handle.net/10722/299688-
dc.description.abstractObjectives To systematically identify and summarize the effectiveness and the parameters of electrical stimulation (ES) for the preservation of visual function in major retinal degeneration and optic neuropathy. Materials and Methods A systematic review of clinical studies, using ES therapy in patients with blind leading retinal degenerations, including retinitis pigmentosa (RP), age‐related macular degeneration (AMD), glaucoma, retinal vein occlusion (RVO), retinal artery occlusion (RAO), and optic neuropathy was conducted. PubMed, EMBASE, Cochrane Library, and Web of Science were searched for relevant interventional studies including randomized controlled trials (RCTs) and observational studies. Results A total of 10 RCTs and 15 observational studies were included. Transcorneal ES (TcES), transpalpebral ES (TpES), transdermal ES (TdES), and repetitive transorbital alternating current stimulation (rtACS) were used for the treatment of the patients. ES using 20 Hz biphasic pulses with current strength at 150%–200% of individual electrical phosphene threshold (EPT) for RP patients showed improved retinal function detected by visual acuity (VA), visual field (VF), or electrical retinal graphs (ERG). rtACS on patients with optic neuropathy showed significant preservation of VA and VF. Clinical studies on AMD, RAO, and glaucoma indicated promising protective effects of ES on the visual function, though the amount of evidence is limited. Conclusions ES treatment has promising therapeutic effects on RP and optic neuropathy. More large‐scale RCT studies should be conducted to elucidate the potential of ES, especially on AMD, RAO, and glaucoma. A comparison of the effects by different ES methods in the same disease populations is still lacking. Parameters of the electric current and sensitive detection method should be optimized for the evaluation of ES treatment effects in future studies.-
dc.languageeng-
dc.publisherBlackwell Publishing, Inc. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1525-1403-
dc.relation.ispartofNeuromodulation-
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subjectElectrical phosphene threshold-
dc.subjectelectrical stimulation-
dc.subjectneuroprotection-
dc.subjectretinal degeneration-
dc.subjectvisual function-
dc.titleEffectiveness of Microcurrent Stimulation in Preserving Retinal Function of Blind Leading Retinal Degeneration and Optic Neuropathy: A Systematic Review-
dc.typeArticle-
dc.identifier.emailLee, VWH: lwhvince@hku.hk-
dc.identifier.emailSo, KF: hrmaskf@hku.hk-
dc.identifier.emailShih, KC: kcshih@hku.hk-
dc.identifier.emailChiu, K: datwai@hku.hk-
dc.identifier.authoritySo, KF=rp00329-
dc.identifier.authorityShih, KC=rp01374-
dc.identifier.authorityLai, JSM=rp00295-
dc.identifier.authorityChiu, K=rp01973-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/ner.13414-
dc.identifier.scopuseid_2-s2.0-85105638469-
dc.identifier.hkuros322547-
dc.identifier.volumeEpub 2021-05-13-
dc.identifier.isiWOS:000649853600001-
dc.publisher.placeUnited States-

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