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Article: Do predetermined surgical margins compromise oncological safety in computer-assisted head and neck reconstruction?

TitleDo predetermined surgical margins compromise oncological safety in computer-assisted head and neck reconstruction?
Authors
KeywordsHead and neck cancer
Reconstruction
Free flap
Survival
Virtual surgical planning
Issue Date2020
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/oraloncology
Citation
Oral Oncology, 2020, v. 111, p. article no. 104914 How to Cite?
AbstractObjectives: Computer assisted head and neck reconstruction has gained popularity over the past few years. In computer assisted surgery (CAS), surgical margins are predetermined in virtual surgery and resection guides are designed to be fitted intra-operatively. However, concerns have been raised regarding the oncological safety of predetermined surgical margins. Therefore, the aim of this study was to compare surgical margins, recurrence and survival outcomes in patients underwent CAS and non-CAS in head and neck reconstruction. Methods: We retrospectively reviewed the patients underwent oral and maxillofacial malignancies surgical excision and free flap reconstruction from October 2014 to December 2019 by the same chief surgeon. Patients were divided into two groups depending on whether CAS and predetermined surgical margins were adopted. The primary outcome was surgical resection margin and the secondary outcomes included recurrence and survival. Results: A total of 66 subjects were recruited with 37 in the CAS group and 29 in the non-CAS group. The follow-up rate was 100%. The average follow-up time was 24.5 months. No significant difference in resection margin was identified between the groups (p = 0.387). Tumor staging, margin status, perineural invasion, lymphovascular invasion and extranodal extension were identified as significant factors influencing survival. Both before and after adjustment for these prognostic factors identified, CAS and non-CAS group showed no significant difference in survival outcome. Conclusion: Predetermined surgical margins do not compromise oncological safety in terms of resection margin, disease recurrence and patient survival.
DescriptionHybrid open access
Persistent Identifierhttp://hdl.handle.net/10722/299720
ISSN
2023 Impact Factor: 4.0
2023 SCImago Journal Rankings: 1.257
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPu, JJ-
dc.contributor.authorChoi, WS-
dc.contributor.authorYu, P-
dc.contributor.authorWong, MCM-
dc.contributor.authorLo, AWI-
dc.contributor.authorSu, YX-
dc.date.accessioned2021-05-26T03:28:07Z-
dc.date.available2021-05-26T03:28:07Z-
dc.date.issued2020-
dc.identifier.citationOral Oncology, 2020, v. 111, p. article no. 104914-
dc.identifier.issn1368-8375-
dc.identifier.urihttp://hdl.handle.net/10722/299720-
dc.descriptionHybrid open access-
dc.description.abstractObjectives: Computer assisted head and neck reconstruction has gained popularity over the past few years. In computer assisted surgery (CAS), surgical margins are predetermined in virtual surgery and resection guides are designed to be fitted intra-operatively. However, concerns have been raised regarding the oncological safety of predetermined surgical margins. Therefore, the aim of this study was to compare surgical margins, recurrence and survival outcomes in patients underwent CAS and non-CAS in head and neck reconstruction. Methods: We retrospectively reviewed the patients underwent oral and maxillofacial malignancies surgical excision and free flap reconstruction from October 2014 to December 2019 by the same chief surgeon. Patients were divided into two groups depending on whether CAS and predetermined surgical margins were adopted. The primary outcome was surgical resection margin and the secondary outcomes included recurrence and survival. Results: A total of 66 subjects were recruited with 37 in the CAS group and 29 in the non-CAS group. The follow-up rate was 100%. The average follow-up time was 24.5 months. No significant difference in resection margin was identified between the groups (p = 0.387). Tumor staging, margin status, perineural invasion, lymphovascular invasion and extranodal extension were identified as significant factors influencing survival. Both before and after adjustment for these prognostic factors identified, CAS and non-CAS group showed no significant difference in survival outcome. Conclusion: Predetermined surgical margins do not compromise oncological safety in terms of resection margin, disease recurrence and patient survival.-
dc.languageeng-
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/oraloncology-
dc.relation.ispartofOral Oncology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectHead and neck cancer-
dc.subjectReconstruction-
dc.subjectFree flap-
dc.subjectSurvival-
dc.subjectVirtual surgical planning-
dc.titleDo predetermined surgical margins compromise oncological safety in computer-assisted head and neck reconstruction?-
dc.typeArticle-
dc.identifier.emailChoi, WS: drwchoi@hku.hk-
dc.identifier.emailWong, MCM: mcmwong@hku.hk-
dc.identifier.emailSu, YX: richsu@hku.hk-
dc.identifier.authorityChoi, WS=rp01521-
dc.identifier.authorityWong, MCM=rp00024-
dc.identifier.authoritySu, YX=rp01916-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.oraloncology.2020.104914-
dc.identifier.pmid32712577-
dc.identifier.scopuseid_2-s2.0-85088293225-
dc.identifier.hkuros322583-
dc.identifier.volume111-
dc.identifier.spagearticle no. 104914-
dc.identifier.epagearticle no. 104914-
dc.identifier.isiWOS:000596294900005-
dc.publisher.placeUnited Kingdom-

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