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Article: The effect of effort-reward imbalance on brain structure and resting-state functional connectivity in individuals with high levels of schizotypal traits

TitleThe effect of effort-reward imbalance on brain structure and resting-state functional connectivity in individuals with high levels of schizotypal traits
Authors
KeywordsEffort-reward imbalance
schizotypal traits
voxel-based morphometry
resting-state functional connectivity
Issue Date2021
PublisherPsychology Press. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/13546805.asp
Citation
Cognitive Neuropsychiatry, 2021, v. 26 n. 3, p. 166-182 How to Cite?
AbstractIntroduction: Effort-reward imbalance (ERI) is a typical psychosocial stress. Schizotypal traits are attenuated features of schizophrenia in the general population. According to the diathesis-stress model, schizotypal traits and psychosocial stress contribute to the onset of schizophrenia. However, few studies examined the effects of these factors on brain alterations. This study aimed to examine relationships between ERI, schizotypal traits and brain structures and functions. Methods: We recruited 37 (13 male, 24 female) participants with high levels of schizotypal traits and 36 (12 male, 24 female) participants with low levels of schizotypal traits by the Schizotypal Personality Questionnaire (SPQ). The Chinese school version of the effort-reward imbalance questionnaire (C-ERI-S) was used to measure ERI. We conducted the voxel-based morphometry (VBM) and whole brain resting-state functional connectivity (rsFC) analysis using reward or stress-related regions as seeds. Results: Participants with high levels of schizotypal traits were more likely to perceive ERI. The severity of ERI was correlated with grey matter volume (GMV) reduction of the left pallidum and altered rsFC among the prefrontal, striatum and cerebellum in participants with high levels of schizotypal traits. Conclusion: ERI is associated with GMV reduction and altered rsFC in individuals with high levels of schizotypal traits.
Persistent Identifierhttp://hdl.handle.net/10722/299746
ISSN
2020 Impact Factor: 1.871
2015 SCImago Journal Rankings: 1.024
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYan, YJ-
dc.contributor.authorHuang, J-
dc.contributor.authorLui, SSY-
dc.contributor.authorCheung, EFC-
dc.contributor.authorMadsen, KH-
dc.contributor.authorChan, RCK-
dc.date.accessioned2021-05-26T03:28:29Z-
dc.date.available2021-05-26T03:28:29Z-
dc.date.issued2021-
dc.identifier.citationCognitive Neuropsychiatry, 2021, v. 26 n. 3, p. 166-182-
dc.identifier.issn1354-6805-
dc.identifier.urihttp://hdl.handle.net/10722/299746-
dc.description.abstractIntroduction: Effort-reward imbalance (ERI) is a typical psychosocial stress. Schizotypal traits are attenuated features of schizophrenia in the general population. According to the diathesis-stress model, schizotypal traits and psychosocial stress contribute to the onset of schizophrenia. However, few studies examined the effects of these factors on brain alterations. This study aimed to examine relationships between ERI, schizotypal traits and brain structures and functions. Methods: We recruited 37 (13 male, 24 female) participants with high levels of schizotypal traits and 36 (12 male, 24 female) participants with low levels of schizotypal traits by the Schizotypal Personality Questionnaire (SPQ). The Chinese school version of the effort-reward imbalance questionnaire (C-ERI-S) was used to measure ERI. We conducted the voxel-based morphometry (VBM) and whole brain resting-state functional connectivity (rsFC) analysis using reward or stress-related regions as seeds. Results: Participants with high levels of schizotypal traits were more likely to perceive ERI. The severity of ERI was correlated with grey matter volume (GMV) reduction of the left pallidum and altered rsFC among the prefrontal, striatum and cerebellum in participants with high levels of schizotypal traits. Conclusion: ERI is associated with GMV reduction and altered rsFC in individuals with high levels of schizotypal traits.-
dc.languageeng-
dc.publisherPsychology Press. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/13546805.asp-
dc.relation.ispartofCognitive Neuropsychiatry-
dc.rightsCognitive Neuropsychiatry. Copyright © Psychology Press.-
dc.rightsPREPRINT This is a preprint of an article whose final and definitive form has been published in the [JOURNAL TITLE] [year of publication] [copyright Taylor & Francis]; [JOURNAL TITLE] is available online at: http://www.informaworld.com/smpp/ with the open URL of your article POSTPRINT ‘This is an electronic version of an article published in [include the complete citation information for the final version of the article as published in the print edition of the journal]. [JOURNAL TITLE] is available online at: http://www.informaworld.com/smpp/ with the open URL of your article.-
dc.subjectEffort-reward imbalance-
dc.subjectschizotypal traits-
dc.subjectvoxel-based morphometry-
dc.subjectresting-state functional connectivity-
dc.titleThe effect of effort-reward imbalance on brain structure and resting-state functional connectivity in individuals with high levels of schizotypal traits-
dc.typeArticle-
dc.identifier.emailLui, SSY: lsy570@hku.hk-
dc.identifier.emailChan, RCK: rckchan@hkucc.hku.hk-
dc.identifier.authorityLui, SSY=rp02747-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/13546805.2021.1899906-
dc.identifier.pmid33706673-
dc.identifier.scopuseid_2-s2.0-85102598376-
dc.identifier.hkuros322505-
dc.identifier.volume26-
dc.identifier.issue3-
dc.identifier.spage166-
dc.identifier.epage182-
dc.identifier.isiWOS:000628064000001-
dc.publisher.placeUnited Kingdom-

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